1,25-(OH)2-vitamin D3 and calcipotriol induce IL-10 receptor gene expression in human epidermal cells

Inflammation Research

Volumn 46, Issue 1, 1997, Pages 32-34

  Michel, G ^a   Gailis, A ^a   Jarzebska Deussen, B ^a   Muschen A ^a   Mirmohammadsadegh, A ^a   Ruzicka, T ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Antipsoriatic drugs; Cytokine receptor; Mechanism of action

Indexed keywords

ANTIPSORIASIS AGENT; CALCIPOTRIOL; CALCITRIOL; INTERLEUKIN 10 RECEPTOR;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; EPIDERMIS CELL; GENE EXPRESSION; GENE INDUCTION; HUMAN; HUMAN CELL; RECEPTOR GENE; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

CALCITRIOL; CELL LINE; DERMATOLOGIC AGENTS; GENE EXPRESSION; HUMANS; KERATINOCYTES; POLYMERASE CHAIN REACTION; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-10; RNA, MESSENGER; RNA-DIRECTED DNA POLYMERASE;

EID: 0031024861     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: 10.1007/s000110050042     Document Type: Article

References (18)

1. Nickoloff BJ. The cytokine network in psoriasis [editorial; comment]. Arch Dermatol 1991;127:871-84.
2. Sauder DN. The role of epidermal cytokines in inflammatory skin diseases. J Invest Dermatol 1990;95:27s-8.
3. Sticherling M, Bornscheuer E, Schroder JM, Christophers E. Localization of neutrophil-activating peptide-1/interleukin-8-immunoreactivity in normal and psoriatic skin. J Invest Dermatol 1991;96:26-30.
4. Schulz B, Michel G, Wagner S, Süss R, Beetz A, Peter RU, et al. Increased expression of epidermal IL-8 receptor in psoriasis. Down-regulation by FK-506 in vitro. J Immunol 1993;151:4399-406.
5. Michel G, Auer H, Kemény L, Böcking A, Ruzicka T. Antioncogene p53 and mitogenic cytokine IL-8 aberrantly expressed in psoriatic skin are inversely regulated by the antipsoriatic drug FK 506. Biochem Pharmacol 1996;51:1315-20.
6. Michel G, Kemeny L, Homey B, Ruzicka T. FK506 in the treatment of inflammatory skin disease: promises and perspectives. Immunol Today 1996;17:106-8.
7. Spits H, de Waal Malefyt R. Functional characterization of human IL-10. Int Arch Allergy Immunol 1992;99:8-15.
8. Vierira P, de Waal Malefyt R, Dang MN, Johnson KE, Kastelein R, Fiorentino DF, et al. Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI. Proc Natl Acad Sci USA 1991;88:1172-6.
9. 3 treatment in psoriasis vulgaris. Br J Dermatol 1986;115:421-9.
10. 3 receptors in human skin biopsies. J Clin Endocrinol Metab 1980;51:1463-5.
11. 3 on the morphologic and biochemical differentiation of cultured human epidermal keratinocytes grown in serum-free conditions. J Invest Dermatol 1986;86:709-14.
12. Solvsten H, Fogh K, Svendsen M, Kristensen P, Astrom A, Kimar R, et al. Normal levels of vitamin D receptor and its message in psoriatic skin. J Invest Dermatol Sympos Proc 1996;1:28-32.
13. 3 receptors in normal and psoriatic skin. J Invest Dermatol 1991;97:230-9.
14. 389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis. Nature Medicine 1995;1:442-7.
15. Michel G, Nowok K, Beetz A, Ried C, Kemény L, Ruzicka T, et al. Novel steroid derivative modulates gene expression of cytokines and growth factors. Skin Pharmacol 1995;8:215-20.
16. Kemény L, Michel G, Dobozy A, Ruzicka T. Cytokine system as potential target for antipsoriatic therapy. Exp Dermatol 1994;3:1-8.
17. Kemény L, Kenderessy AS, Olasz E, Michel G, Ruzicka T, Dobozy A. The interleukin-8 receptor: a potential target for antipsoriatic therapy. Eur J Pharmacol 1994;258:269-72.
18. Carlberg C. The concept of multiple vitamin D signaling pathways. J Invest Dermatol Sympos Proc 1996;1:10-14.