Underexpression of Gcm2, a master regulatory gene of parathyroid gland development, in adenomas of primary hyperparathyroidism

Clinical Endocrinology

Volumn 57, Issue 4, 2002, Pages 501-505

  Correa, Pamela ^a   Åkerström, Göran ^a   Westin, Gunnar ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GCM2; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CARCINOGENESIS; CLINICAL ARTICLE; CONTROLLED STUDY; GENETIC TRANSCRIPTION; HUMAN; HUMAN TISSUE; NERVOUS TISSUE; NUCLEOTIDE SEQUENCE; ORGANOGENESIS; PARATHYROID ADENOMA; PARATHYROID GLAND; PRIMARY HYPERPARATHYROIDISM; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REGULATOR GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UREMIA;

ADENOMA; ADULT; AGED; CELL TRANSFORMATION, NEOPLASTIC; DOWN-REGULATION; DROSOPHILA PROTEINS; FEMALE; HUMANS; HYPERPARATHYROIDISM; MIDDLE AGED; NEOPLASM PROTEINS; PARATHYROID GLANDS; PARATHYROID NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, NEOPLASM;

EID: 0036402079     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.2002.01627.x     Document Type: Article

References (19)

1. Akiyama, Y., Hosoya, T., Poole, A.M. & Hotta, Y. (1996) The gcm-motif: a novel DNA-binding motif conserved in drosophila and mammals. Proceedings of the National Academy of Sciences of the United States of America, 93, 14912-14916.
2. Altschuller, Y., Copeland, N.G., Gilbert, D.J., Jenkins, N.A. & Frohman, M.A. (1996) Gcm1, a mammalian homolog of Drosophila glial cells missing. FEBS Letters, 393, 201-204.
3. Arnold, A. (1994) Molecular basis of primary hyperparathyroidism. In The Parathyroids (eds J. Bilezikan, R. Marcus & M. Levine), pp. 457-470. Raven Press Ltd, New York.
4. Arnold, A., Brown, M.F., Urena, P., Gaz, R.D., Sarfati, E. & Drueke, T.B. (1995) Monoclonality of parathyroid tumors in chronic renal failure and in primary parathyroid hyperplasia. Journal of Clinical Investigation, 95, 2047-2053.
5. Arnold, A., Staunton, C.E., Kim, H.G., Gaz, R.D. & Kronenberg, H.M. (1988) Monoclonality and abnormal parathyroid hormone genes in parathyroid adenomas. New England Journal of Medicine, 318, 658-662.
6. Bernardoni, R., Vivancos, B. & Giangrande, A. (1997) Glide/gcm is expressed and required in the scavenger cell lineage. Developmental Biology, 191, 118-130.
7. Carling, T., Correa, P., Hessman, O., Hedberg, J., Skogseid, B., Lindberg, D., Rastad, J., Westin, G. & Åkerström, G. (1998) Parathyroid MEN1 gene mutations in relation to clinical characteristics of nonfamilial primary hyperparathyroidism. Journal of Clinical Endocrinology and Metabolism, 83, 2960-2963.
8. Gibson, U.E., Heid, C.A. & Williams, P.M. (1996) A novel method for real time quantitative RT-PCR. Genome Research, 6, 995-1001.
9. Günther, T., Chen, Z.F., Kim, J., Priemel, M., Rueger, J.M., Amling, M., Moseley, J.M., Martin, T.J., Anderson, D.J. & Karsenty, G. (2000) Genetic ablation of parathyroid glands reveals another source of parathyroid hormone. Nature, 406, 199-203.
10. Heppner, C., Kester, M.B., Agarwal, S.K., Debelenko, L.V., Emmert-Buck, M.R., Guru, S.C., Manickam, P., Olufemi, S.E., Skarulis, M.C., Doppman, J.L., Alexander, R.H., Kim, Y.S., Saggar, S.K., Lubensky, I.A., Zhuang, Z., Liotta, L.A., Chandrasekharappa, S.C., Collins, F.S., Spiegel, A.M., Burns, A.L. & Marx, S.J. (1997) Somatic mutation of the MEN1 gene in parathyroid tumors. Nature Genetics, 6, 375-378.
11. Hosoya, T., Takizawa, K., Nitta, K. & Hotta, Y. (1995) Glial cells missing: a binary switch between neuronal and glial determination in Drosophila. Cell, 82, 1025-1036.
12. Jones, B.W., Fetter, R.D., Tear, G. & Goodman, C.S. (1995) Glial cells missing: a genetic switch that controls glial versus neuronal fate. Cell, 82, 1013-1023.
13. Kammerer, M., Pirola, B., Giglio, S. & Giangrande, A. (1999) GCMB, a second human homolog of the fly glide/gcm gene. Cytogenetics and Cell Genetics, 84, 43-47.
14. Kanemura, Y., Hiraga, S., Arita, N., Ohnishi, T., Izumoto, S., Mori, K., Matsumura, H., Yamasaki, M., Fushiki, S. & Yoshimine, T. (1999) Isolation and expression analysis of a novel human homologue of the Drosophila glia cells missing (gcm) gene. FEBS Letters, 442, 151-156.
15. Kim, J., Jones, B.W., Zock, C., Wang, H., Goodman, C.S. & Anderson, D.J. (1998) Isolation and characterization of mammalian homologs of the Drosophila gene glial cells missing. Proceedings of the National Academy of Sciences of the United States of America, 95, 12364-12369.
16. Manley, N.R. & Capecchi, M.R. (1998) Hox group 3 paralogs regulate the development and migration of the thymus, thyroid and parathyroid glands. Developmental Biology, 195, 1-15.
17. Schreiber, J., Sock, E. & Wegner, M. (1997) The regulator of early gliogenesis gliagenesis glial cells missing is a transcription factor with a novel type of DNA-binding domain. Proceedings of the National Academy of Sciences of the United States of America, 94, 4739-4744.
18. Tahara, H., Smith, A.P., Gaz, R.D., Cryns, V.L. & Arnold, A. (1996) Genomic localization of novel candidate tumor suppressor gene loci in human parathyroid adenomas. Cancer Research, 56, 599-605.
19. Vincent, S., Vonesch, J.L. & Giangrande, A. (1996) Glide directs glial fate commitment and cell fate switch between neurones and glia. Development, 122, 131-139.