메뉴 건너뛰기




Volumn 23, Issue 1-3, 2002, Pages 19-25

Inhibition of phosphatidylcholine synthesis is associated with excitotoxic cell death in cerebellar granule cell cultures

Author keywords

Excitotoxicity; Glutamate; Neuronal death; Phosphatidylcholine

Indexed keywords

CHOLINE; CHOLINE KINASE; GLUCOSE; GLUTAMIC ACID; PHOSPHATIDYLCHOLINE; PHOSPHORYLCHOLINE;

EID: 0036392017     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-001-0104-8     Document Type: Article
Times cited : (3)

References (17)
  • 2
    • 0029940901 scopus 로고    scopus 로고
    • Removal of serum from primary cultures of cerebellar granule neurons induces oxidative stress and DNA fragmentation: Protection with antioxidants and glutamate receptor antagonists
    • Atabay C, Cagnoli CM, Kharlamov E, Ikonomovic MD, Manev H (1996) Removal of serum from primary cultures of cerebellar granule neurons induces oxidative stress and DNA fragmentation: protection with antioxidants and glutamate receptor antagonists. J Neurosci Res 43: 465-475
    • (1996) J Neurosci Res , vol.43 , pp. 465-475
    • Atabay, C.1    Cagnoli, C.M.2    Kharlamov, E.3    Ikonomovic, M.D.4    Manev, H.5
  • 3
    • 0027339958 scopus 로고
    • Desensitization of the NMDA receptor complex by glycinergic ligands in cerebellar granule cell cultures
    • Boje KM, Wong G, Skolnick P (1993) Desensitization of the NMDA receptor complex by glycinergic ligands in cerebellar granule cell cultures. Brain Res 603: 207-214
    • (1993) Brain Res , vol.603 , pp. 207-214
    • Boje, K.M.1    Wong, G.2    Skolnick, P.3
  • 4
    • 0034674620 scopus 로고    scopus 로고
    • Choline release and inhibition of phosphatidylcholine synthesis precede excitotoxic neuronal death but not neurotoxicity induced by serum deprivation
    • Gasull T, DeGregorio-Rocasolano N, Zapata A, Trullas R (2000) Choline release and inhibition of phosphatidylcholine synthesis precede excitotoxic neuronal death but not neurotoxicity induced by serum deprivation. J Biol Chem 275: 18350-18357
    • (2000) J Biol Chem , vol.275 , pp. 18350-18357
    • Gasull, T.1    DeGregorio-Rocasolano, N.2    Zapata, A.3    Trullas, R.4
  • 5
    • 0035083685 scopus 로고    scopus 로고
    • Overactivation of alpha-amino-3-hydroxy-5-methylisoazole-4-propionate and N-methyl-D-aspartate but not kainate receptors inhibits phosphatidylcholine synthesis before excitotoxic neuronal death
    • Gasull T, DeGregorio-Rocasolano N, Trullas R (2001) Overactivation of alpha-amino-3-hydroxy-5-methylisoazole-4-propionate and N-methyl-D-aspartate but not kainate receptors inhibits phosphatidylcholine synthesis before excitotoxic neuronal death. J Neurochem 77: 13-22
    • (2001) J Neurochem , vol.77 , pp. 13-22
    • Gasull, T.1    DeGregorio-Rocasolano, N.2    Trullas, R.3
  • 6
    • 0002582057 scopus 로고
    • Discovery of the pathways for the biosynthesis of phosphatidylcholine
    • Vance DE (ed). CRC Press, Boca Raton, FL
    • Kennedy EP (1989) Discovery of the pathways for the biosynthesis of phosphatidylcholine. In: Vance DE (ed) Phosphatidylcholine metabolism. CRC Press, Boca Raton, FL, pp 1-9
    • (1989) Phosphatidylcholine Metabolism , pp. 1-9
    • Kennedy, E.P.1
  • 7
    • 0025111206 scopus 로고
    • Small rises in plasma choline reverse the negative arteriovenous difference of brain choline
    • Klein J, Köppen A, Löffelholz K (1990) Small rises in plasma choline reverse the negative arteriovenous difference of brain choline. J Neurochem 55: 1231-1236
    • (1990) J Neurochem , vol.55 , pp. 1231-1236
    • Klein, J.1    Köppen, A.2    Löffelholz, K.3
  • 8
    • 0024357646 scopus 로고
    • Excitatory amino acid neurotoxicity at the N-methyl-D-aspartate receptor in cultured neurons: Pharmacological characterization
    • Lysko PG, Cox JA, Vigano A, Henneberry RC (1989) Excitatory amino acid neurotoxicity at the N-methyl-D-aspartate receptor in cultured neurons: pharmacological characterization. Brain Res 499: 258-266
    • (1989) Brain Res , vol.499 , pp. 258-266
    • Lysko, P.G.1    Cox, J.A.2    Vigano, A.3    Henneberry, R.C.4
  • 10
    • 0025063609 scopus 로고
    • Excitatory amino acid neurotoxicity and neurodegenerative disease
    • Meldrum B, Garthwaite J (1990) Excitatory amino acid neurotoxicity and neurodegenerative disease. Trends Pharmacol Sci 11: 379-387
    • (1990) Trends Pharmacol Sci , vol.11 , pp. 379-387
    • Meldrum, B.1    Garthwaite, J.2
  • 11
    • 0020326450 scopus 로고
    • Choline administration elevates brain phosphorylcholine concentrations
    • Millington WR, Wurtman RJ (1982) Choline administration elevates brain phosphorylcholine concentrations. J Neurochem 38: 1748-1752
    • (1982) J Neurochem , vol.38 , pp. 1748-1752
    • Millington, W.R.1    Wurtman, R.J.2
  • 12
    • 0023895734 scopus 로고
    • Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced
    • Novelli A, Reilly JA, Lysko PG, Henneberry RC (1988) Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced. Brain Res 451: 205-212
    • (1988) Brain Res , vol.451 , pp. 205-212
    • Novelli, A.1    Reilly, J.A.2    Lysko, P.G.3    Henneberry, R.C.4
  • 13
    • 0031032299 scopus 로고    scopus 로고
    • Use of a multiwell fluorescence scanner with propidium iodide to assess NMDA mediated excitotoxicity in rat cortical neuronal cultures
    • Rudolph JG, Lemasters JJ, Crews FT (1997) Use of a multiwell fluorescence scanner with propidium iodide to assess NMDA mediated excitotoxicity in rat cortical neuronal cultures. Neurosci Lett 221: 149-152
    • (1997) Neurosci Lett , vol.221 , pp. 149-152
    • Rudolph, J.G.1    Lemasters, J.J.2    Crews, F.T.3
  • 14
    • 0025139268 scopus 로고
    • Serum and depolarizing agents cause acute neurotoxicity in cultured cerebellar granule cells: Role of the glutamate receptor responsive to N-methyl-D-aspartate
    • Schramm M, Eimerl S, Costa E (1990) Serum and depolarizing agents cause acute neurotoxicity in cultured cerebellar granule cells: role of the glutamate receptor responsive to N-methyl-D-aspartate. Proc Natl Acad Sci USA 87: 1193-1197
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 1193-1197
    • Schramm, M.1    Eimerl, S.2    Costa, E.3
  • 15
    • 77956834896 scopus 로고
    • Phospholipid metabolism and cell signalling in eucaryotes
    • Vance DE, Vance J (eds). Elsevier Science Publishers, Amsterdam
    • Vance DE (1991) Phospholipid metabolism and cell signalling in eucaryotes. In: Vance DE, Vance J (eds) Biochemistry of lipids, lipoproteins and membranes. Elsevier Science Publishers, Amsterdam, pp 205-240
    • (1991) Biochemistry of Lipids, Lipoproteins and Membranes , pp. 205-240
    • Vance, D.E.1
  • 16
    • 0031836539 scopus 로고    scopus 로고
    • Glycine site antagonists and partial agonists inhibit N-methyl-D-aspartate receptro-mediated [3H] arachidonic acid release in cerebellar granule cells
    • Viu E, Zapata A, Capdevila JL, Fossom LH, Skolnick P, Trullas R (1998) Glycine site antagonists and partial agonists inhibit N-methyl-D-aspartate receptro-mediated [3H] arachidonic acid release in cerebeller granule cells. J Pharmacol Exp Ther 285: 527-532
    • (1998) J Pharmacol Exp Ther , vol.285 , pp. 527-532
    • Viu, E.1    Zapata, A.2    Capdevila, J.L.3    Fossom, L.H.4    Skolnick, P.5    Trullas, R.6
  • 17
    • 0032525089 scopus 로고    scopus 로고
    • Region-specific and calcium-dependent increase in dialysate choline levels by NMDA
    • Zapata A, Capdevila JL, Trullas R (1998) Region-specific and calcium-dependent increase in dialysate choline levels by NMDA. J Neurosci 18: 3597-3605
    • (1998) J Neurosci , vol.18 , pp. 3597-3605
    • Zapata, A.1    Capdevila, J.L.2    Trullas, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.