Protective effects of urinary trypsin inhibitor (UTI) on hepatic microvasculature in hypotensive brain-dead rats

European Surgical Research

Volumn 34, Issue 4, 2002, Pages 330-338

  Itabashi, K ^a,b   Ito, Y ^a   Takahashi, T ^a   Ishii, K ^a   Sato, K ^a   Kakita, A ^a  

^a KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KITASATO UNIVERSITY HOSPITAL   (Japan)

Author keywords

Brain death; Hepatic microvasculature; Liver transplantation; Marginal donors; Urinary trypsin inhibitor

Indexed keywords

ASPARTATE AMINOTRANSFERASE; CYTOKINE; CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT; INTERCELLULAR ADHESION MOLECULE 1; TUMOR NECROSIS FACTOR ALPHA; ULINASTATIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BALLOON CATHETER; BRAIN DEATH; CELL INTERACTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; HEMODYNAMICS; HYPOTENSION; KUPFFER CELL; LEUKOCYTE COUNT; LIVER CIRCULATION; LIVER FUNCTION; LIVER PROTECTION; LIVER SINUSOID; MALE; MEAN ARTERIAL PRESSURE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; TREATMENT OUTCOME;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BILE; BLOOD PRESSURE; BRAIN DEATH; CHEMOKINES; CHEMOKINES, CXC; CHEMOTACTIC FACTORS; GLYCOPROTEINS; HEART RATE; HYPOTENSION; IMMUNOHISTOCHEMISTRY; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERLEUKIN-1; KUPFFER CELLS; LIVER; LIVER CIRCULATION; LIVER TRANSPLANTATION; MALE; MICROCIRCULATION; MICROSCOPY, ELECTRON; NEUTROPHILS; RATS; RATS, INBRED LEW; TISSUE DONORS; TRYPSIN INHIBITORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036391926     PISSN: 0014312X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000063074     Document Type: Article

References (30)

1. Novitzky D, Cooper DKC, Reichart B: Hemodynamic and metabolic responses to hormonal therapy in brain-dead potential organ donors. Transplantation 1987;43:852-854.
2. Zaloga GP: Endocrine function after brain death. Crit Care Med 1990;18:785-786.
3. Halevy A, Brody B: Brain death: Reconciling, definitions, criteria, and tests. Ann Intern Med 1993;119:519-525.
4. Herijgers P, Leunens V, Tjandra-Maga TB, Mubagwa K, Flameng W: Changes in organ perfusion after brain death in the rat and its relation to circulating catecholamines. Transplantation 1996;62:330-335.
5. Pratschke J, Wilhelm MJ, Kusaka M, Basker M, Cooper DKC, Hancock WW, Tilney NL: Brain death and its influence on donor organ quality and outcome after transplantation. Transplantation 1999;67:343-348.
6. Briceno J, Lopez-Cillero P, Rufian S, Diaz-Iglesias C, Solorzano G, Padillo J, De la Mata M, Pera C: Impact of marginal quality donors on the outcome of liver transplantation. Transplant Proc 1997;29:477-480.
7. Takada M, Nadeau KC, Hancock WW, Mackenzie HS, Shaw GD, Waaga AM, Chandraker A, Sayegh MH, Tilney NL: Effects of Explosive brain death on cytokine activation of peripheral organs in the rat. Transplantation 1998;65:1533-1542.
8. van der Hoeven JA, Ploeg RJ, Postema F, Molema I, De Vos P, Girbes AR, Van Suylichem PT, Van Schilfgaarde R, Ter Horst GJ: Induction of organ dysfunction and up-regulation of inflammatory markers in the liver and kidneys of hypotensive brain death rats: A model to study marginal organ donors. Transplantation 1999;68:1884-1890.
9. Johnson RJ, Couser WG, Alpers CE, Vissers M, Schulze M, Klebanoff SJ: The human neutrophil serine proteases, elastase and cathepsin G, can mediate glomerular injury in vivo. J Exp Med 1988;168:1169-1174.
10. Watanabe K, Konishi K, Fujioka M, Kinoshita S, Nakagawa H: The neutrophil chemoattractant produced by the rat kidney epithelial cell line NRK-52E is a protein related to the KC/gro protein. J Biol Chem 1989;264:19559-19563.
11. Muramatsu M, Mori S, Matsuzawa Y, Horiguchi Y, Nakanishi Y, Tanaka M: Purification and characterization of urinary trypsin inhibitor, UTI68, from normal human urine, and its cleavage by human uropepsin. J Biochem 1980;88:1317-1329.
12. Nishiyama T, Hirasaki A: Effect of ulinastatin on the elastase release in multiple injuries. Anesth Resusc 1994;30:77-80.
13. Li XK, Matin AF, Suzuki H, Uno T, Yamaguchi T, Harada Y: Effect of protease inhibitor on ischemia/reperfusion injury of the rat liver. Transplantation 1993;56:1331-1336.
14. Aosasa S, Ono S, Seki S, Takayama E, Tadakuma T, Hiraide H, Mochizuki H: Inhibitory effect of protease inhibitor on endothelial cell activation. J Surg Res 1998;80:182-187.
15. Aihara T, Shiraishi M, Hiroyasu S, Hatsuse K, Mochizuki H, Seki S, Hiraide H, Muto Y: Ulinastatin, a protease inhibitor, attenuates hepatic ischemia/reperfusion injury by downregulating TNF-α in the liver. Tlansplant Proc 1998;30:3732-3734.
16. Onumata O, Takahashi T, Sato K, Kakita A: Effects of ulinastatin on hypotension and hepatic circulation in brain-dead rabbits. Transplant Proc 2000;32:2290-2292.
17. Tani T, Abe H, Endo Y, Hanasawa K, Komada M: Effects of a urinary trypsin inhibitor on acute circulatory insufficiency after surgical operation. Am J Surg 1998;175:142-145.
18. Tawadrous MN, Zhang XY, Wheatley AM: Microvascular origin of laser-Doppler flux signal from the surface of normal and injured liver of the rat. Microvasc Res 2001;62:355-365.
19. Imai K, Sato K, Ito Y, Nakayama Y, Takahashi T, Kakita A: Hormokinetics and histopathological evaluation of rabbit brain death model. Transplant Proc 1996;28:1273-1274.
20. Cardullo LD, Morilla R, Catovsky D: Significance of phi bodies in acute leukemia. J Clin Pathol 1981;34:153-157.
21. van der Hoeven JA, Ter Horst GJ, Molema G, De Vos P, Girbes ARJ, Postema F, Freund RL, Wiersema J, Van Schilfgaarde R, Ploeg RJ: Effects of brain death and hemodynamic status on function and immunologic activation of the potential donor liver in the rat. Ann Surg 2000;232:804-813.
22. Kusaka M, Pratschke J, Wilhelm MJ, Ziai F, Zandi-Nejad K, Mackenzie HS, Hancock WW, Tilney NL: Activation of inflammatory mediators in rat renal isografts by donor brain death. Transplantation 2000;69:405-410.
23. Wilhelm MJ, Pratschke J, Beato F, Taal M, Kusaka M, Hancock WW, Tilney NL: Activation of the heart by donor brain death accelerates acute rejection after transplantation. Circulation 2000;102:2426-2433.
24. Amado JA, Lopez-Espadas F, Vazquez-Barquero A, Salas E, Riancho JA, Lopez-Cordovilla JJ, Garcia-Unzueta MT: Blood levels of cytokine in brain-dead patients: Relationship with circulating hormones and acute-phase reactants. Metabolism 1996;44:812-816.
25. Okamoto S, Corso CO, Kondo T, Leiderer R, Rascher W, Yamamoto Y, Yamaoka Y, Messmer K: Changes in hepatic microcirculation and histopathology in brain-dead organ donors: An experimental study in rats. Eur J Surg 1999;165:759-766.
26. Kamiike W, Nakahara M, Naoko M, Koseki M, Nishida T, Kawashima Y, Watanabe F, Tagawa K: Correlation between cellular ATP level and bile excretion in the rat liver. Transplantation 1989;39:50-55.
27. 31P NMR spectroscopy. J Surg Res 1993;55:599-606.
28. Ito Y, Atmadja WL, Machen NW, Baker GL, McCuskey RS: Effect of intravenous immunoglobulin G on the TNFα-mediated hepatic microvascular inflammatory response. Shock 1999;11:291-295.
29. Watanabe K, Suematsu M, Iida M, Takaishi K, Iizuka Y, Suzuki H, Suzuki M, Tsuchiya M, Tsurufuji S: Effect of rat CINC/gro, a member of interleukin-8 family, on leukocytes in microcirculation of the rat mesentery. Exp Mol Pathol 1992;56:60-69.
30. Yamaguchi Y, Ohshiro H, Nagao Y, Odawara K, Okabe K, Hidaka H, Ishihara K, Uchino S, Furuhashi T, Yamada S, Mori K, Ogawa M: Urinary trypsyn inhibitor reduces C-X-C chemokine production in rat liver ischemia/reperfusion. J Surg Res 2000;94:107-115.