Stimulation of angiogenesis by Cyr61 gene: A new therapeutic candidate

Human Gene Therapy

Volumn 13, Issue 12, 2002, Pages 1461-1470

  Fataccioli, Virginie ^a,b   Abergel, Valérie ^a   Wingertsmann, Laure ^a   Neuville, Pascal ^b   Spitz, Estelle ^b   Adnot, Serge ^a   Calenda, Valérie ^b   Teiger, Emmanuel ^a  

^a HENRI MONDOR HOSPITAL   (France)

^b TRANSGENE S A   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; BINDING PROTEIN; CYSTEINE RICH PROTEIN 61; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMORAL ARTERY; HEMODYNAMIC MONITORING; HINDLIMB; HUMAN; HUMAN CELL; LEG BLOOD FLOW; MALE; MUSCLE ISCHEMIA; NONHUMAN; PERFUSION; RABBIT; RANDOMIZATION; TRANSGENE;

ADENOVIRIDAE; ANIMALIA; DNA VIRUSES; ORYCTOLAGUS CUNICULUS;

EID: 0036385767     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430340260185094     Document Type: Article

References (31)

1. ARRAS, M., ITO, W.D., SCHOLZ, D., WINKLER, B., SCHAPER, J., and SCHAPER, W. (1998). Monocyte activation in angiogenesis and collateral growth in the rabbit hindlimb. J. Clin. Invest. 101, 40-50.
2. BABIC, A.M., KIREEVA, M.L., KOLESNIKOVA, T.V., and LAU, L.F. (1998). CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth. Proc. Natl. Acad. Sci. U.S.A. 95, 6355-6360.
3. BAFFOUR, R., ACHANTA, K., KAUFMAN, J., BERMAN, J., GARB, J.L., RHEE, S., and FRIEDMANN, P. (1995). Synergistic effect of basic fibroblast growth factor and methylprednisolone on neurological function after experimental spinal cord injury. J. Neurosurg. 83, 105-110.
4. BAUMGARTNER, I., PIECEK, A., MANOR, O., BLAIR, R., KEARNEY, M., WALSH, K., and ISNER, J.M. (1998). Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia. Circulation 97, 1114-1123.
5. BAUTERS, C., ASAHARA, T., ZHENG, L.P., TAKESHITA, S., BUNTING, S., FERRARA, N., SYMES, J.F., and ISNER J.M. (1994). Physiological assessment of augmented vascularity induced by VEGF in ischemic rabbit hindlimb. Am. J. Physiol. 267, H1263-H12671.
6. BRUNNER, A., CHINN, J., NEUBAUER, M., and PURCHIO, A.F. (1991). Identification of a gene family regulated by transforming growth factor-β. DNA Cell. Biol. 10, 293-300.
7. CHARTIER, C., DEGRYSE, E., KANTZER, M., DIETERLE, A., PAVIRANI, A., and MEHTALI, M. (1996). Efficient generation of recombinant adenovirus vectors by homologous recombination in Escherichia coli. J. Virol. 70, 4805-4810.
8. CHEN, C.C., CHEN, N., and LAU, L.F. (2001). The angiogenic factors Cyr61 and CTGF induce adhesive signaling in primary human skin fibroblasts. J. Biol. Chem. 276, 10443-10452.
9. v integrins. Science 270, 1500-1502.
10. GARCIA-MARTINEZ, C., OPOLON, P., TRONCHON, V., CHIANALE, C., MUSSET, K., LU, H., ABITBOL, M., PERRICAUDET, M., and RAGOT, T. (1999). Angiogenesis induced in muscle by a recombinant adenovirus expressing functional isoforms of basic fibroblast growth factor. Gene Ther. 6, 1210-1221.
11. 3, independent of its carboxy-terminal domain. J. Biol. Chem. 276, 21943-21950.
12. HAMMOND, H.K., and MCKIRNAN, M.D. (2001). Angiogenic gene therapy for heart disease: A review of animal studies and clinical trials. Cardiovasc. Res. 49, 561-567.
13. KIREEVA, M.L., MO, F.E., YANG, G.P., and LAU, L.F. (1996). Cyr61, a product of a growth factor-inducible immediate-early gene, promotes cell proliferation, migration, and adhesion. Mol. Cell. Biol. 16, 1326-1334.
14. KIREEVA, M.L., LATINKIC, B.V., KOLESNIKOVA, T.V., CHEN, C.C, YANG, G.P., ABLER, A.S., and LAU, L.F. (1997). Cyr61 and Fisp12 are both ECM-associated signaling molecules: Activities, metabolism, and localization during development. Exp. Cell Res. 233, 63-77.
15. 3. J. Biol. Chem. 273, 3090-3096.
16. KOLESNIKOVA, T.V., and LAU, L.F. (1998). Human CYR61-mediated enhancement of bFGF-induced DNA synthesis in human umbilical vein endothelial cells. Oncogene 16, 747-754.
17. LAU, L.F., and LAM, S.C. (1999). The CCN family of angiogenic regulators: The integrin connection. Exp. Cell Res. 248, 44-57.
18. LAU, L.F., and NATHANS, D. (1985). Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells. EMBO J. 4, 3145-3151.
19. LAU, L.F., and NATHANS, D. (1987). Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: Coordinate regulation with c-fos or c-myc. Proc. Natl. Acad. Sci. U.S.A. 84, 1182-1186.
20. LAZAROUS, D.F., UNGER, E.F., EPSTEIN, S.E., STINE, A., AREVALO, J.L., CHEW, E.Y., and QUYYUMI, A.A. (2000). Basic fibroblast growth factor in patients with intermittent claudication: Results of a phase I trial. J. Am. Coll. Cardiol. 36, 1239-1244.
21. LUSKY, M., CHRIST, M., RITNER, K., DIETERLE, A., DREYER, D., MOUROT, B., SCHULTZ, H., STOECKEL, F., PAVIRANI, A., and MEHTALI, M. (1998). In vitro and in vivo biology of recombinant adenovirus vectors with E1, E1/E2A, or E1/E4 deleted. J. Virol. 72, 2022-2032.
22. MACK, C.A., PATEL, S.R., SCHWARZ, E.A., ZANZONICO, P., HAHN, R.T., ILERCIL, A., DEVEREUX, R.B., GOLDSMITH, S.J., CHRISTIAN, T.F., SANBORN, T.A., KOVESDI, I., HACKETT, N., ISOM, O.W., CRYSTAL, R.G., and ROSENGART, T.K. (1998). Biologic bypass with the use of adenovirus-mediated gene transfer of the complementary deoxyribonucleic acid for vascular endothelial growth factor 121 improves myocardial perfusion and function in the ischemic porcine heart. J. Thorac. Cardiovasc. Surg. 115, 168-176; discussion 176-177.
23. O'BRIEN, T.P., YANG, G.P., SANDERS, L., and LAU, L.F. (1990). Expression of cyr61, a growth factor-inducible immediate-early gene. Mol. Cell. Biol. 10, 3569-3577.
24. PU, L.Q., SNIDERMAN, A.D., BRASSARD, R., LACHAPELLE, K.J., GRAHAM, A.M., LISBONA, R., and SYMES, J.F. (1993). Enhanced revascularization of the ischemic limb by angiogenic therapy. Circulation 88, 208-215.
25. RIVARD, A., SILVER, M., CHEN, D., KEARNEY, M., MAGNER, M., ANNEX, B., PETERS, K., and ISNER, J.M. (1999). Rescue of diabetes-related impairment of angiogenesis by intramuscular gene therapy with adeno-VEGF. Am. J. Pathol. 154, 355-363.
26. SAFI, J., DIPAULA, A.F., RICCIONI, T., KAJSTURA, J., AMBROSIO, G., BECKER, L.C., ANVERSA, P., and CAPOGROSSI, M.P. (1999). Adenovirus-mediated acidic fibroblast growth factor gene transfer induces angiogenesis in the nonischemic rabbit heart. Microvasc. Res. 58, 238-249.
27. TAKESHITA, S., ZHENG, L.P., BROGI, E., KEARNEY, M., PU, L.Q., BUNTING, S., FERRARA, N., SYMES, J.F., and ISNER, J.M. (1994). Therapeutic angiogenesis: A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model. J. Clin. Invest. 93, 662-670.
28. TAKESHITA, S., WEIR, L., CHEN, D., ZHENG, L.P., RIESSEN, R., BAUTERS, C., SYMES, J.F., FERRARA, N., and ISNER, J.M. (1996). Therapeutic angiogenesis following arterial gene transfer of vascular endothelial growth factor in a rabbit model of hindlimb ischemia. Biochem. Biophys. Res. Commun. 227, 628-635.
29. WITZENBICHLER, B., ASAHARA, T., MUROHARA, T., SILVER, M., SPYRIDOPOULOS, I., MAGNER, M., PRINCIPE, N., KEARNEY, M., HU, J.S., and ISNER, J.M. (1998). Vascular endothelial growth factor-C (VEGF-C/VEGF-2) promotes angiogenesis in the setting of tissue ischemia. Am. J. Pathol. 153, 381-394.
30. YANG, G.P., and LAU, L.F. (1991). Cyr61, product of a growth factor-inducible immediate early gene, is associated with the extracellular matrix and the cell surface. Cell Growth Differ. 2, 351-357.
31. ZIADA, A.M., HUDLICKA, O., TYLER, K.R., and WRIGHT, A.J. (1984). The effect of long-term vasodilatation on capillary growth and performance in rabbit heart and skeletal muscle. Cardiovasc. Res. 18, 724-732.