Effects of ethanol to water ratio in feed solution on the crystallinity of spray-dried lactose

Drug Development and Industrial Pharmacy

Volumn 28, Issue 8, 2002, Pages 949-955

  Harjunen, Päivi ^a   Lehto, Vesa Pekka ^b   Välisaari, Jouni ^c   Lankinen, Tapio ^d   Paronen, Petteri ^a   Järvinen, Kristiina ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

^c UNIVERSITY OF JYVÄSKYLÄ   (Finland)

^d Focus Inhalation Oy   (Finland)

Author keywords

Crystallinity; Lactose; Spray drying

Indexed keywords

ALCOHOL; ALPHA LACTOSE; CRYSTALLIN; SURFACE WATER; WATER; LACTOSE;

ANALYTIC METHOD; ARTICLE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG INDUSTRY; HYDRATION; MICROCALORIMETRY; SPRAY DRYING; THERMOGRAVIMETRY; WATER CONTENT; CALORIMETRY; CHEMISTRY; METHODOLOGY; SCANNING ELECTRON MICROSCOPY; SOLUTION AND SOLUBILITY;

CALORIMETRY; CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; ETHANOL; LACTOSE; MICROSCOPY, ELECTRON, SCANNING; PHARMACEUTICAL SOLUTIONS; THERMOGRAVIMETRY; WATER;

EID: 0036383203     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.1081/DDC-120006427     Document Type: Article

References (14)

1. Broadhead, J.; Edmond Rouan, S.K.; Rhodes, C.T. The Spray Drying Pharmaceuticals. Drug Dev. Ind. Pharm. 1992, 18 (11&12), 1169-1206.
2. Briggner, L.E.; Buckton, G.; Bystrom, K.; Darcy, P. The Use of Isothermal Microcalorimetry in the Study of Changes in Crystallinity Induced During the Processing of Powders. Int. J. Pharm. 1994, 105, 125-135.
3. Ueno, Y.; Yonemochi, E.; Yamamura, S.; Tozuka, Y.; Yamamura, S.; Oguchi, T.; Yamamoto, K. Characterization of Amorphous Ursodeoxycholic Acid Prerared by Spray-Drying. J. Pharm. Pharmacol. 1998, 50, 1213-1219.
4. Hancock, B.C.; Parks, M. What Is the True Solubility Advantage for Amorphous Pharmaceuticals? Pharm. Res. 2000, 17 (4), 397-404.
5. Buckton, G.; Darcy, P. The Influence of Additives on the Recrystallisation of Amorphous Spray Dried Lactose. Int. J. Pharm. 1995, 121, 81-87.
6. Buckton, G.; Darcy, P. Water Mobility in Amorphous Lactose Below and Close to the Glass Transition Temperature. Int. J. Pharm. 1996, 136, 141-146.
7. Vidgren, P.; Vidgren, M.; Paronen, P. Physical Stability and Inhalation Behaviour of Mechanically Micronized and Spray Dried Disodium Cromoglycate in Different Humidities. Acta Pharm. Fenn. 1989, 98, 71-78.
8. Buckton, G.; Darcy, P.; Greenleaf, D.; Holbrook, P. The Use of Isothermal Microcalorimetry in the Study of Changes in Crystallinity of Spray-Dried Salbutamol Sulphate. Int. J. Pharm. 1995, 116, 113-118.
9. Sebhatu, T.; Angberg, M.; Ahlneck, C. Assessment of the Degree of Disorder in Crystalline Solid by Isothermal Microcalorimetry. Int. J. Pharm. 1994, 104, 135-144.
10. Chidavaenzi, O.C.; Buckton, G.; Koosha, F.; Pathak, R. The Use of Thermal Techniques to Assess the Impact offeed Concentration on the Amorphous Content and Polymorphic Forms Present in Spray Dried Lactose. Int. J. Pharm. 1997, 159, 67-74.
11. Angberg, M.; Nyström, C.; Castensson, S. Evaluation of Heat-Conduction Microcalorimetry in Pharmaceutical Stability Studies. V. A New Approach for Continuous Measurements in Abundant Water Vapour. Int. J. Pharm. 1992, 81, 153-167.
12. Angberg, M.; Nyström, C.; Castensson, S. Evaluation of Heat-Conduction Microcalorimetry in Pharmaceutical Stability Studies. VI. Continuous Monitoring of the Interaction of Water Vapour with Powders and Powder Mixtures at Various Relative Humidities. Int. J. Pharm. 1992, 83, 11-23.
13. Stubberud, L.; Forbes, R.T. The Use of Gravimetry for the Study of the Effect of Additives on the Moisture-Induced Recrystallisation of Amorphous Lactose. Int. J. Pharm. 1998, 163, 145-156.
14. Naini, V.; Byron, P.R.; Phillips, E.M. Physicochemical Stability of Crystalline Sugars and Their Spray-Dried Forms: Dependence upon Relative Humidity and Suitability for Use in Powder Inhalers. Drug Dev. Ind. Pharm. 1998, 24 (10), 895-909.