Amino acid and protein targets of 1,2-diacetylbenzene, a potent aromatic γ-diketone that induces proximal neurofilamentous axonopathy

Toxicology and Applied Pharmacology

Volumn 183, Issue 1, 2002, Pages 55-65

  Kim, Min Sun ^a   Hashemi, Seyed B ^a   Spencer, Peter S ^a   Sabri, Mohammad I ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Aromatic solvent; Axonopathy; Chromophore; Diacetylbenzene; Neurofilament; Protein adducts; diketone

Indexed keywords

1,2 DIACETYLBENZENE; 1,3 DIACETYLBENZENE; 1,3 DIKETONE; 1,4 DIKETONE; 2,4 HEXANEDIONE; ACETONYLACETONE; ALIPHATIC COMPOUND; AMINO ACID; AROMATIC COMPOUND; BETA TUBULIN; KETONE DERIVATIVE; LYSINE; NINHYDRIN; POLYMER; STRUCTURAL PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SWELLING; CHEMICAL REACTION; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG TARGETING; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROTUBULE; NERVE FIBER; NEUROFILAMENT; NEUROPATHY; NONHUMAN; PROTEIN POLYMERIZATION; RAT; TOXICOKINETICS;

RODENTIA;

EID: 0036382897     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.2002.9456     Document Type: Article

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