Effects of lerisetron, a new 5-HT3 receptor antagonist, on ipecacuanha-induced emesis in healthy volunteers

Arzneimittel-Forschung/Drug Research

Volumn 52, Issue 9, 2002, Pages 689-694

  Cooper, Mark ^a   Sologuren, Ander ^a   Valiente, Roman ^a   Smith, Jeffery ^a  

^a SIMBEC RESEARCH LTD   (United Kingdom)

Author keywords

5 HT3 receptor antagonists; Anti emetics; CAS 143257 98 1; Emesis, ipecacuanha induced; F 0930 RS2; Lerisetron, anti emetic effect, volunters

Indexed keywords

GRANISETRON; LERISETRON; PLACEBO;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DOSE CALCULATION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FLUSHING; HUMAN; HUMAN EXPERIMENT; MALE; NAUSEA; NORMAL HUMAN; VOMITING;

EID: 0036380759     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1299952     Document Type: Article

References (11)

1. Gunning, S. J., Hagan, R. M., Tyers, B. M., Cisplatin induces biochemical and histological changes in the small intestine of the ferret. Br. J. Pharmacol. 90, 135 (1987)
2. Roberts, J. T., Priestman, T. J., A review of ondansetron in the management of radiotherapy-induced emesis. Oncology, 50, 173 (1993)
3. Tramer, M. R., Reynolds, D. J. M., Stoner, N. S. et al., Efficacy of 5-HT3 receptor antagonists in radiotherapy-induced nausea and vomiting: A quantitative systemic review. Eur. J. Cancer 34, 1836 (1998)
4. Orjales, A., Mosquera, R., Labega, L. et al., New 2-Piperazinylbenzimidazole derivatives as 5-HT3 Antagonists. Synthesis and pharmacologicai evaluation. J. Med. Chem. 40, 586 (1997)
5. Gomez-de-Segura, I. A., Grande, A. G., De Miguel, E., Anti-emetic effects of lerisetron in radiation-induced emesis in the dog. Acta Oncol. 37, 759 (1998)
6. Labeaga, L., Corcóstegui, R., Innerárity, A. et al., Effect of lerisetron on gastric distension and emesis induced by cisplatin in rodents and dogs. Methods Find. Exp. Clin. Pharmacol. 21 (Suppl. A), 187 (1999)
7. Minton, N., Swift, R., Lawlor, C., Ipecacuanha-induced emesis: A human model for testing anti-emetic drug activity. Clin. Pharmacol. Ther. 54, 53 (1993)
8. Minton, A., Volunteers models for predicting anti-emetic activity of 5-HT3-receptor antagonists. Br. J. Clin. Pharmacol. 37, 525 (1994)
9. Hammas, B., Hvarener, A., Thorn, S. E. et al., Effects of propofol on ipecacuanha-induced nausea and vomiting. Acta Anaesthesiol. Scand. 42, 447 (1998)
10. Schwartz, S. M., Goldberg, M. J., Gidda, J. S., Effect of Zatoseron on ipecac-induced emesis in dogs and healthy men. J. Clin. Pharmacol. 34, 250 (1994)
11. Czajka, P. A., Russel, S. L., Non-emetic effects of ipecac syrup. Pediatrics 75, 1101 (1985)