Inhibition of neuronal firing in murine striatal slices by cyclodiene insecticides is mediated by release of dopamine and not GABA antagonism

Pesticide Biochemistry and Physiology

Volumn 73, Issue 1, 2002, Pages 59-65

  Freeborn, Ethan R ^a   Bloomquist, Jeffrey R ^a  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

Author keywords

Dieldrin; Heptachlor; Heptachlor epoxide; Picrotoxinin; Striatum

Indexed keywords

MURINAE;

EID: 0036380567     PISSN: 00483575     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0048-3575(02)00024-X     Document Type: Article

References (25)

1. F. Matsumura, Insecticide residues in man, in: Toxicology of Insecticides, Plenum Press, New York, 1985, pp. 547-568.
2. F. Corrigan, L. Murray, C. Wyatt, R. Shore, Diortho substituted polychlorinated biphenyls in caudate nucleus in Parkinson's disease, Exp. Neurol. 150 (1998) 339.
3. L. Fleming, J. Mann, J. Bean, T. Briggle, J. Sanchez-Ramos, Parkinson's disease and brain levels of organochlorine insecticides, Ann. Neurol. 36 (1994) 100.
4. J. Sanchez-Ramos, A. Facca, A. Basit, S. Song, Toxicity of dieldrin for dopaminergic neurons in mesencephalic cultures, Exp. Neurol. 150 (1998) 263.
5. D. Shankland, M. Schroeder, Pharmacological evidence for a discrete neurotoxic action of dieldrin (HEOD) in the American cockroach, Periplaneta americana (L.), Pestic. Biochem. Physiol. 3 (1973) 77.
6. R. Joy, Mode of action of lindane, dieldrin and related insecticides in the central nervous system, Neurobehav. Toxicol. Teratol. 4 (1982) 813.
7. K. Nagata, T. Narahashi, Dual action of the cyclodiene insecticide dieldrin on the GABA receptor-chloride channel complex of rat dorsal root ganglion neurons, J. Pharmacol. Exp. Ther. 269 (1993) 164.
8. I. Abalis, M. Eldefrawi, A. Eldefrawi, Effects of insecticides on GABA-induced chloride influx into rat brain vesicles, J. Toxicol. Environ. Health 18 (1986) 13.
9. J. Bloomquist, P. Adams, D. Soderlund, Inhibition of γ-aminobutyric acid-stimulated chloride flux in mouse brain vesicles by polychlorocycloalkane and pyrethroid insecticides, NeuroToxicology 7 (1986) 11.
10. L. Cole, J. Casida, Polychlorocycloalkane insecticide-induced convulsions in mice in relation to disruption of the GABA-regulated chloride ionophore, Life Sci. 39 (1986) 1855.
11. L. Akkermans, J. Bercken, J. Zalm, H. Straaten, Effects of dieldrin (HEOD) and some of its metabolites on synaptic transmission in the frog motor end-plate, Pestic. Biochem. Physiol. 4 (1974) 313.
12. S. Publicover, C. Duncan, The action of lindane in accelerating the spontaneous release of transmitter at the frog neuromuscular junction, Naunyn-Schmiedeberg's Arch. Pharmacol. 381 (1979) 179.
13. I. Yamaguchi, F. Matsumura, A. Kadous, Inhibition of synaptic ATPases by heptachlor epoxide in rat brain, Pestic. Biochem. Physiol. 11 (1979) 285.
14. I. Yamaguchi, F. Matsumura, A. Kadous, Heptachlor epoxide: effects on calcium-mediated transmitter release from brain synaptosomes in rat, Biochem. Pharmacol. 29 (1980) 1815.
15. M. Kirby, R. Barlow, J. Bloomquist, Neurotoxicity of the organochlorine insecticide heptachlor to murine striatal dopaminergic pathways, Toxicol. Sci. 61 (2001) 100.
16. A. Brooks-Kayal, M. Shumate, H. Jin, T. Rikhter, D. Coulter, Selective changes in single cell GABAA receptor subunit expression and function in temporal lobe epilepsy, Nature Med. (United States) 10 (1998) 1166.
17. S. Fountain, Y. Ting, T. Teyler, The in vitro hippocampal slice preparation as a screen for neurotoxicity, Toxicol. in vitro 6 (1990) 77.
18. D. Purves, G. Augusting, D. Fitzpatrick, L. Katz, A.-S. LaMantia, J. McNamara, in: Neuroscience, Sinaur Associates, Sunderland, MA, 1997, pp. 329-344.
19. C. Dreyfuss, B. Beer, D. Devine, B. Roberts, E. Schreiber, Fluphenazine-induced Parkinsonism in the baboon: Pharmacological and metabolic studies, Neuropharmacology 11 (1972) 223.
20. X. Gu, A. Blatz, D. German, Subtypes of substantia nigra dopaminergic neurons revealed by apamin: autoradiographic and electrophysiological studies, Brain Res. Bull. 28 (1992) 435.
21. M. Kirby, R. Barlow, J. Bloomquist, Selective effects of organochlorine insecticides on dopamine release in mammalian synaptosomes, Toxicol. Appl. Pharmacol. 181 (2002) 89.
22. D. Gant, M. Eldefrawi, A. Eldefrawi, Cyclodiene insecticides inhibit GABAA receptor-mediated chloride transport, Toxicol. Appl. Pharmacol. 88 (1987) 313.
23. J.R. Bloomquist, Intrinsic lethality of chloride channel-directed insecticides and convulsants in mammals, Toxicol. Lett. 60 (1992) 289.
24. F. Filloux, J. Townsend, Pre- and postsynaptic neurotoxic effects of dopamine demonstrated by intrastriatal injection, Exp. Neurol. 119 (1993) 79.
25. I. Ziv, E. Melamed, N. Nardi, D. Luria, A. Achiron, D. Offen, A. Barzilai, Dopamine induces apoptosis-like cell death in cultured chick sympathetic neurons: a possible novel pathogenic mechanism in Parkinson's disease, Neurosci. Lett. 170 (1994) 136.