Neurotoxicity of the organochlorine insecticide hepatachlor to murine striatal dopaminergic pathways

Toxicological Sciences

Volumn 61, Issue 1, 2001, Pages 100-106

  Kirby, Michael L ^a,b   Barlow, Rebecca L ^a   Bloomquist, Jeffrey R ^a,c  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^b LONG BEACH MEMORIAL MEDICAL CENTER   (United States)

^c Dept of Entomology   (United States)

Author keywords

Cyclodiene; Dopamine; Dopamine release; Dopamine uptake; Parkinsonism; Respiration

Indexed keywords

DOPAMINE; DOPAMINE TRANSPORTER; HEPTACHLOR; HEPTACHLOR EPOXIDE; ORGANOCHLORINE INSECTICIDE; SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; BRAIN CORTEX; BREATHING RATE; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE BRAIN LEVEL; DOPAMINE RELEASE; DOPAMINERGIC NERVE CELL; DOPAMINERGIC SYSTEM; DOSE RESPONSE; IN VITRO STUDY; MALE; MEASUREMENT; MOUSE; MOUSE STRAIN; NERVE ENDING; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; RESPIRATION DEPRESSION; SEROTONIN RELEASE; SEROTONINERGIC SYSTEM; SYNAPSE; SYNAPTOSOME;

ANIMALS; CELL MEMBRANE; CORPUS STRIATUM; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPTACHLOR; INSECTICIDES; MALE; MICE; MICE, INBRED C57BL; NEUROTOXICITY SYNDROMES; NEUROTRANSMITTER AGENTS; OXYGEN; OXYGEN CONSUMPTION; POLAROGRAPHY; SENSITIVITY AND SPECIFICITY; SYNAPTOSOMES; TRITIUM;

ANIMALIA; MURINAE;

EID: 0035036218     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/61.1.100     Document Type: Article

References (43)

1. Complementary positron emission tomographic studies of the striatal dopaminergic system in Parkinson's disease
2. Evaluation of human exposure to the heptachlor epoxide contamination of milk in Hawaii
3. Toxicology, mode of action and target site-mediated resistance to insecticides acting on chloride channels
4. Effects of Heptachlor Exposure on Neurochemical Biomarkers of Parkinsonism
5. A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein-dye binding
6. Finger tremor after carbon disulfide-based pesticide exposures
7. Polychlorocycloalkaline insecticide-induced convulsions in mice in relation to disruption of the GABA-regulated chloride ionophore
8. Diorthosubstituted polychlorinated biphenyls in caudate nucleus in Parkinson's disease
9. Effects of endosulfan and its metabolites on rat liver mitochondrial respiration and enzyme activities in vitro
10. Parkinson's disease and brain levels of organochlorine insecticides
11. Anaerobic glycolysis and postanoxic recovery of respiration of rat cortical synaptosomes are reduced by synaptosomal sodium load
12. Studies on 1,2,3,6-tetrahydropyridine derivatives as potential monoamine oxidase in activators
13. Dopamine and norepinephrine depletion in ring doves fed DDE, dieldrin, and Aroclor 1254
14. Chronic fluoxetine treatment upregulates 5-HT uptake sites and 5-HT2 receptors in rat brain: An autoradiographic study
15. Single positron emission computed tomographic imaging demonstrates loss of striatal dopamine transporters in Parkinson's disease
16. Exposure to well water and pesticides in Parkinson's disease: A case-control study in the Madrid area
17. In vivo effects of deltamethrin on dopamine neurochemistry and the role of augmented neurotransmitter release
18. Environmental risk factors in Parkinson's disease
19. Kinetics and block of dopamine uptake in synaptosomes from rat caudate nucleus
20. Insecticide residues in man
21. Effect of heptachlor on hepatic mitochondrial oxidative phosphorylation in rat
22. Heptachlor alters expression and function of dopamine transporters
23. Chronic intermittent, but not continuous, cocaine administration produces sensitization and dopamine transporter upregulation
24. Effects of endosulfan on bioenergetic properties of liver mitochondria from the freshwater catfish Claria batrachus
25. Environmental equity and pesticide exposure
26. Microsomal oxidation and insecticide metabolism
27. The dopamine transporter is absent in parkinsonian putamen and reduced in the caudate nucleus
28. Effect of chlordane on hepatic mitochondrial respiration
29. p-Chlorphenylalanine changes serotonin transporter mRNA levels and expression of the gene product
30. Parkinson's disease mortality and the industrial use of heavy metals in Michigan
31. Toxicity of dieldrin for dopaminergic neurons in mesencephalic cultures
32. Parkinson's disease and exposure to agricultural work and pesticide chemicals
33. Parkinson's disease: A test of the multifactorial etiologic hypothesis
34. Possible environmental, occupational, and other etiological factors for Parkinson's disease: A case-control study in Germany
35. Brain biogenic amines: Depletion by chronic dieldrin exposure
36. Hawaiian milk contamination creates alarm. A sour response by state regulators
37. Do environmental toxins cause Parkinson's disease? A critical review
38. Parkinson disease in twins an etiologic study
39. Transmitter synthesis increases in substantia nigra neurons of the aged mouse
40. Effect of acute and chronic dieldrin exposure on brain biogenic amines of male and female rats
41. Environmental risk factors in siblings with Parkinson's disease
42. Heptachlor epoxide: Effects on calcium-mediated transmitter release from brain synaptosomes in rat