Association analysis of Arg16Gly polymorphism of the β2-adrenergic receptor gene in offspring from hypertensive and normotensive families

Blood Pressure

Volumn 11, Issue 4, 2002, Pages 213-217

  Jindra, Antonín ^a   Horky K ^a   Peleska J ^a   Jachymova M ^a   Bultas, J ^a   Umnerova V ^a   Heller, S ^a   Hlubocka Z ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

Author keywords

2 adrenergic receptor; Blood pressure; Genetic predisposition; Genetics; Hypertension

Indexed keywords

ARGININE; BETA 2 ADRENERGIC RECEPTOR; GLYCINE; RESTRICTION ENDONUCLEASE;

ADULT; AGAR GEL ELECTROPHORESIS; AGE; ARTICLE; BODY MASS; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE PREDISPOSITION; ESSENTIAL HYPERTENSION; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HEART RATE; HOMOZYGOTE; HUMAN; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; NORADRENALIN BLOOD LEVEL; POLYMERASE CHAIN REACTION; POPULATION RESEARCH; PRIORITY JOURNAL; PROGENY; RECESSIVE GENE; RISK ASSESSMENT; STATISTICAL SIGNIFICANCE; SYSTOLIC BLOOD PRESSURE; TACHYCARDIA; CASE CONTROL STUDY; FAMILY HEALTH; GENETIC PREDISPOSITION; GENETICS; HYPERTENSION; MISSENSE MUTATION; NUCLEOTIDE SEQUENCE; RISK; STATISTICAL MODEL;

ADULT; CASE-CONTROL STUDIES; DNA MUTATIONAL ANALYSIS; FAMILY HEALTH; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; HYPERTENSION; LOGISTIC MODELS; MALE; MUTATION, MISSENSE; ODDS RATIO; POLYMORPHISM, GENETIC; RECEPTORS, ADRENERGIC, BETA-2;

EID: 0036380277     PISSN: 08037051     EISSN: None     Source Type: Journal    
DOI: 10.1080/08037050213761     Document Type: Article

References (25)

1. Ward R. Familial aggregation and genetic epidemiology of blood pressure. In: Laragh JH, Brenner BM, editors. Hypertension, pathophysiology, diagnosis, and management. New York: Raven Press, 1990: 81-100.
2. Julius S. The evidence for a pathophysiologic significance of the sympathetic overactivity in hypertension. Clin Exp Hypertens 1996; 18: 305-21.
3. Jindra A, Jáchymová M, Horký K, et al. Association analysis of two tyrosine hydroxylase gene polymorphisms in normotensive offspring from hypertensive families. Blood Press 2000; 9: 250-4.
4. 2-adrenergic phenotypic traits in normotensive humans at genetic risk of hereditary (essential) hypertension. J Hypertens 1998; 16: 779-92.
5. 2c10-adrenergic receptor genotype. Hypertension 1996; 27: 1210-5.
6. 2-adrenergic receptor locus. Hypertension 1997; 29: 918-22.
7. 2-adrenoceptor. Hypertension 1997; 30: 773-6.
8. Timmermann B, Mo R, Luft FC, et al. β-2 adrenoceptor genetic variation is associated with genetic predisposition to essential hypertension: The Bergen Blood Pressure Study. Kidney Int 1998; 53: 1455-60.
9. -adrenergic receptor gene as a susceptibility locus for human hypertension. Circulation 2000; 101: 2877-82.
10. 2-adrenoceptor gene polymorphisms and blood pressure variations in East Anglian Caucasians. J Hypertens 2000; 18: 687-93.
11. 2-adrenergic receptor polymorphisms: no association with essential hypertension in black or white Americans. Clin Pharmacol Ther 2000; 67: 670-5.
12. 2adrenoceptor polymorphisms with hypertension in a black African population. J Hypertens 2000; 18: 167-72.
13. Skrabal F, Kotanko P, Luft FC. Minireview: Inverse regulation of α-2 and β-2 adrenoceptors in salt-sensitive hypertension: An hypothesis. Life Sci 1989; 45: 2061-76.
14. Horký K. Jáchymová M, Jindra A, et al. Metabolic, humoral and haemodynamic characteristics of normotensive off-spring from hypertensive families. J Hum Hypertens 1996; 10 Suppl 3: S85-S87.
15. Brown MJ, Struthers AD, Burrin JM, Di Silvio L, Brown DC. The physiological and pharmacological role of presynaptic alpha- and beta-adrenoceptors in man. Br J Clin Pharmacol 1985; 20: 649-58.
16. -2 adrenergic receptor gene variations, blood pressure, and heart size in normal twins. Hypertension 2000; 35: 550-60.
17. 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry 1994; 33: 9414-9.
18. 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells. Am J Respir Cell Mol Biol 1995; 13: 25-33.
19. 2-adrenergic receptor variants affect resting blood pressure and agonist-induced vasodilation in young adult Caucasians. Hypertension 1999; 33: 1425-30.
20. Arner P. Control of lipolysis and its relevance to development of obesity in man. Diabetes Met Rev 1988; 4: 507-15.
21. Lafontan M, Barbe P, Galitzky J, et al. Adrenergic regulation of adipocyte metabolism. Hum Reprod 1997; 12 (Suppl 1): 6-20.
22. 2-adrenergic receptor gene with obesity, hypertriglyceridaemia, and diabetes mellitus. Diabetologia 1999; 42: 98-101.
23. 2-adrenergic receptor gene on obesity in a French population. Int J Obesity 2000; 24: 382-7.
24. Fossum E, Berge KE, Hoieggen A, et al. Polymorphisms in candidate genes for blood pressure regulation in young men with normal or elevated screening blood pressure. Blood Press 2001; 10: 92-100.
25. Sharma AM, Jeunemaitre X. The future of genetic association studies in hypertension: improving the signal-to-noise ratio. J Hypertens 2000; 18: 811-4.