Conotoxin MI inhibits the α-δ acetylcholine binding site of the Torpedo marmorata receptor

Biochemical and Biophysical Research Communications

Volumn 295, Issue 4, 2002, Pages 791-795

  Cortez, Leonardo M ^a   Del Canto, Sergio G ^a   Testai, Fernando D ^a   Biscoglio de Jiménez Bonino, Mirtha J ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Conotoxin MI; Conus; Ligand binding sites; Nicotinic receptors; Torpedo marmorata

Indexed keywords

ACETYLCHOLINE; ALPHA BUNGAROTOXIN; CARBACHOL; CELL RECEPTOR; CONOTOXIN; CONOTOXIN MI; NICOTINIC RECEPTOR; UNCLASSIFIED DRUG;

AFFINITY CHROMATOGRAPHY; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; LIGAND BINDING; NONHUMAN; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEIN INTERACTION; RECEPTOR BINDING; TORPEDO MARMORATA;

ACETYLCHOLINE; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; BUNGAROTOXINS; CARBACHOL; CONOTOXINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; PROTEIN BINDING; RECEPTORS, NICOTINIC; SPECIES SPECIFICITY; TORPEDO;

TORPEDO; TORPEDO CALIFORNICA; TORPEDO MARMORATA;

EID: 0036375908     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)00758-1     Document Type: Article

References (20)

1. The α-conotoxins GI and MI distinguish between the nicotinic acetylcholine receptor agonist sites while SI does not
2. α-Conotoxin selectively inhibits one of the two acetylcholine binding sites of nicotinic receptors
3. Glycosylation sites selectively interfere with alpha-toxin binding to the nicotinic acetylcholine receptor
4. α-Conotoxins, small peptide probes of nicotinic acetylcholine receptors
5. Alpha-Conotoxin EI, a new nicotinic acetylcholine receptor antagonist with novel selectivity
6. Solution conformation of alpha-conotoxin EI, a neuromuscular toxin specific for the alpha1/delta subunit interface of Torpedo nicotinic acetylcholine receptor
7. Involvement of Histidine 134 in the binding of α-bungarotoxin to the nicotinic acetylcholine receptor
8. 4
9. Role of histidine residues in the α-bungarotoxin binding site of the nicotinic acetylcholine receptor
10. Production and assay of antibodies to acetylcholine receptors
11. Radioiodination of a photoactivatable heterobifunctional reagent
12. Residues at the subunit interfaces of the nicotinic acetylcholine receptor that contribute to α-conotoxin M1 binding
13. Relationship between the binding site for an α-conotoxin and snake venom neurotoxins in the nicotinic acetylcholine receptor from Torpedo californica
14. Molecular basis of the two nonequivalent ligand binding sites of the muscle nicotinic acetylcholine receptor
15. d-Tubocurarine binding sites are located at α-γ and α-δ subunit interfaces of the nicotinic acetylcholine receptor
16. γ and δ subunits regulate the affinity and the cooperativity of ligand binding to the acetylcholine receptor
17. Molecular dissection of subunit interfaces in the acetylcholine receptor: Identification of determinants of α-conotoxin M1 selectivity
18. Isolation and structure of a peptide toxin from the marine snail Conus magus
19. Conotoxin MI. Disulfide bonding and conformational states
20. Photoactivatable α-conotoxins reveal contacts with all subunits as well as antogonist-induced rearrangements in the T. californica acetylcholine receptor