Towards the development of selective amine oxidase inhibitors: Mechanism-based inhibition of six copper containing amine oxidases

European Journal of Biochemistry

Volumn 269, Issue 15, 2002, Pages 3645-3658

  Shepard, Eric M ^a   Smith, Jennifer ^a   Elmore, Bradley O ^a   Kuchar, Jason A ^a   Sayre, Lawrence M ^b   Dooley, David M ^a  

^a MONTANA STATE UNIVERSITY   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Amine oxidase; Copper; Enzyme inhibition; Mechanism based inhibition

Indexed keywords

1,4 DIAMINO 2 BUTYNE; 1,4 DIAMINO 2 CHLORO 2 BUTENE; 1,6 DIAMINO 2,4 HEXADIYNE; 2 CHLORO 5 PHTHALIMIDOPENTYLAMINE; 4 (2 NAPHTHYLOXY) 2 BUTYN 1 AMINE; AMINE OXIDASE (COPPER CONTAINING); CHEMICAL COMPOUND; MONOAMINE OXIDASE INHIBITOR; PROTEIN; PROTEIN LYSINE 6 OXIDASE; SCHIFF BASE; UNCLASSIFIED DRUG;

ALKYLATION; ARTHROBACTER; ARTICLE; BACTERIUM; CATTLE; CHEMICAL MODEL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME BLOOD LEVEL; ENZYME INACTIVATION; ENZYME MECHANISM; ESCHERICHIA COLI; FUNGUS; HORSE; MAMMAL; NONHUMAN; PEA; PICHIA PASTORIS; PLANT; PRIORITY JOURNAL; SEEDLING; STOICHIOMETRY;

AMINE OXIDASE (COPPER-CONTAINING); ANIMALS; BACTERIA; DIAMINES; DIHYDROXYPHENYLALANINE; DRUG DESIGN; ENZYME INHIBITORS; MAMMALS; MODELS, MOLECULAR; NAPHTHALENES; PHENYLHYDRAZINES; PROTEIN CONFORMATION; PROTEIN-LYSINE 6-OXIDASE; SPECIES SPECIFICITY; TIME FACTORS; TITRIMETRY;

ARTHROBACTER; ARTHROBACTER GLOBIFORMIS; BACTERIA (MICROORGANISMS); BOS TAURUS; BOVINAE; EQUIDAE; EQUUS CABALLUS; ESCHERICHIA COLI; FUNGI; MAMMALIA; PICHIA; PICHIA PASTORIS; PISUM SATIVUM;

EID: 0036373077     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2002.03035.x     Document Type: Article

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