The ovariectomised sheep as a model for testing biomaterials and prosthetic devices in osteopenic bone: A preliminary study on iliac crest biopsies

International Journal of Artificial Organs

Volumn 23, Issue 4, 2000, Pages 275-281

  Fini, Milena ^a   Pierini, G ^b   Giavaresi, G ^a   Biagini, G ^b   Belmonte, M Mattioli ^b   Aldini, N Nicoli ^a   Rocca, M ^a   Martini, L ^a   Giardino, R ^a  

^a RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

^b Ist di Ric Codivilla Putti IOR ^*

Author keywords

Biomaterials; Implants; Osteoporosis; Ovariectomy; Sheep

Indexed keywords

BIOMATERIALS; BIOPSY; BONE; SCANNING ELECTRON MICROSCOPY;

ADIPOSE TISSUE; BONE MATRIX; BONE VOLUME; CELL VOLUME; CONTROL GROUPS; IMPLANT; PROSTHETIC DEVICES; SHEEP; TRABECULAR BONES; TRABECULAR THICKNESS;

ANIMALS;

BIOMATERIAL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOCOMPATIBILITY; BIOMEDICAL TECHNOLOGY ASSESSMENT; BONE BIOPSY; BONE DENSITY; CONTROLLED STUDY; EXPERIMENTAL MODEL; ILIAC CREST; IMPLANT; NONHUMAN; OSTEOPENIA; OSTEOPOROSIS; OVARIECTOMY; PROSTHESIS; SHEEP; TRABECULAR BONE;

EID: 0034033377     PISSN: 03913988     EISSN: None     Source Type: Journal    
DOI: 10.1177/039139880002300411     Document Type: Article

References (41)

1. Ceder L. Hip fracture treatment: from local to multinational assessment. Hip International 1998; 8: 99-101.
2. Parker MJ, Currie CT, Mountain JA, Thorngren KG. Standardised audit of hip fracture in Europe (SAHFE). Hip International 1998; 8: 10-15.
3. Khosla S, Melton J III. Secondary osteoporosis. In: Lawrence Riggs B., Melton III U, eds. Osteoporosis: Etiology, Diagnosis and Management. Philadelphia: Lippincott-Raven Publisher, 1995; 183-204.
4. Kleerekoper M, Avioli LV. Osteoporosis pathogenesis and therapy. In: Avioli LV, Krane SM, eds. Metabolic bone disease. San Diego: Academic Press, 1998; 387-409.
5. Aroldi A, Ponticelli C. Skeletal complications after renal transplantation. Int J Artif Organs 1998; 21: 251-3.
6. Gennari C, Martini G, Nuti R. Secondary osteoporosis. Aging 1998; 10:214-24.
7. Alfaro-Adrian J, Crawford RW, Wulke A, Murray DW, McLardy-Smith PM. Proximal cementing for revision hip arthroplasty. Hip International 1998; 8: 62-9.
8. Newman E, Turner AS, Wark JD. The potential of sheep for the study of osteopenia: current status and comparison with other animal models. Bone 1995; 16: 277S-84S.
9. Barrios C, Brostrom LA, Stark A, Walheim G. Healing complications after internal fixation of trochanteric hip fractures: the prognostic value of osteoporosis. J Orthop Trauma 1993; 7: 438-42.
10. Baxter JC, Fattore L. Osteoporosis and osseointegration of implants. J Prosthodont 1993; 2: 120-5.
11. Blomqvist JE, Alberius P, Isaksson S, Linde A, Hansson BG. Factors in implant integration failure after bone grafting: an osteometric and endocrinologic matched analysis. Int J Oral Maxillofac Surg 1996; 25: 63-8.
12. Linder L, Carlsson A, Marsal L, Bjursten LM, Branemark Pl. Clinical aspects of osseointegration in joint replacement. A histologic study of titanium implants. J Bone Joint Surg (Br) 1988; 70: 550-5.
13. Fini M, Nicoli Aldini N, Gandolfi MG, et al. Biomaterials for orthopaedic surgery in osteoporotic bone: a comparative study in osteopenic rats. Int J Artif Organs 1997; 20: 291-7.
14. Fujimoto T, Numi A, Sawai T, Ueda M. Effects of steroid-induced osteoporosis on osseointegration of titanium implants. Int J Oral Maxillofac Implants 1998; 13: 183-9.
15. Hayashi K, Uenoyama K, Matsuguchi N, Nakagawa S, Sugioka Y. The affinity of bone to hydroxyapatite and alumina in experimentally induced osteoporosis. J Arthroplasty 1989; 4: 256-62.
16. Hayashi K, Uenoyama K, Mashima T, Sugioka Y. Remodelling of bone around hydroxyapatite and titanium in experimental osteoporosis. Biomaterials 1994; 15: 11-6.
17. Martin RB, Paul HA, Bargar WL, Dannucci GA, Sharkey NA. Effects of estrogen deficiency on the growth of tissue into porous titanium implants. J Bone Joint Surg (Am) 1988; 70: 540-7.
18. Mattioli Belmonte M, De Benedittis A, Muzzarelli RAA, et al. Bioactivity modulation of bioactive materials in view of their application in osteoporotic patients. J Mater Sci Mat Med 1998; 9: 485-92.
19. Mori H, Manabe M, Kurachi Y, Nagumo M. Osseointegration of dental implants in rabbit bone with low mineral density. J Oral Maxillofac Surg 1997; 55: 351-62.
20. De Benedittis A, Mattioli Belmonte M, et al. In vitro and in vivo assessment of bone-implant interface: a comparative study. Int J Artif Organs 1999; 22: 516-21.
21. Fini M, Giavaresi G, Torricelli P, et al. Biocompatibility and osteointegration studies related to osteoporosis: a preliminary in vitro and in vivo study. J Bone Joint Surg (Br) (In press).
22. Fini M, Giavaresi G, Nicoli Aldini N, et al. The effect of osteopenia on the oseointegration of different biomaterials: histomorphometric study in rats. J Mat Sci Mat Med 11, 2000 (In press).
23. Rocca M, Orienti L, Stea S, Moroni A, Fini M, Giardino R. Comparison among three different biocoatings for orthopaedic prostheses. An experimental animal study. Int J Artif Organs 1998; 21: 553-8.
24. Geusens P, Boonen S, Niys J, et al. Effect of salmon calcitonin on femoral bone quality in adult ovariectomized ewes. Calcif Tissue lnt 1996; 59(4): 315-20.
25. Homby SB, Ford SL, Mase CA, Evans GP. Skeletal changes in the ovariectomised ewe and subsequent response to treatment with 17 beta oestradiol. Bone 1995; 17: 389S-94S.
26. Johnson RB, Gilbert JA, Cooper RC, et al. Alveolar bone loss one year following ovariectomy in sheep. J Periodontol 1997; 68: 864-71.
27. Selzman CH, Gaynor JS, Turner AS, et al. Ovarian ablation alone promotes aortic intimai hyperplasia and accumulation of fibroblast growth factor. Circulation 1998; 98: 2049-54.
28. Selzman CH, Gaynor JS, Turner AS, Whitehill TA, Horwitz LD, Harken AH. Estrogen replacement inhibits intimal hyperplasia and the accumulation and effects of transforming growth factor beta 1. J Surg Res 1998; 80: 380-5.
29. Thorndike EA, Turner AS. In search of an animal model for postmenopausal diseases. Front Biosc 1998; 3: 17-26.
30. Turner AS, Mallinckrodt CH, Alvis MR, Bryant HU. Dose-response effects of estradiol implants on bone mineral density in ovariectomized ewes. Bone 1995; 17: 421S-7S.
31. Turner AS, Alvis M, Myers W, Stevens ML, Lundy MW. Changes in bone mineral density and bone-specific alkaline phosphatase in ovariectomized ewes. Bone 1995; 17: 395S-402S.
32. Turner AS, Athanasiou KA, Zhu CF, Alvis MR, Bryant HU. Biochemical effects of estrogen on articular cartilage in ovariectomized sheep. Osteoarthritis Cartilage 1997; 5: 63-9.
33. Chavassieux P, Pastoureau P, Boivin G, Chapuy MC, Delmas PD, Meunier PJ. Dose effects on ewe bone remodeling of short-term sodium fluoride administration. A histomorphometric study. Bone 1991; 12: 421-7.
34. Weinhold PS, Roe SC, Gilbert JA, Abrams CF. Assessment of the directional elastic moduli of ewe vertebral cancellous bone by vibrational testing. Ann Biomed Eng 1999; 27: 103-10.
35. Monier-Faugere MC, Langub MC, Malluche HH. Bone biopsies: a modern approach. In: Avioli LV, Krane SM, eds. Metabolic bone diseases and clinically related disorders. San Diego: Academic Press 1998; 237-73.
36. Parfitt AM, Drezner MK, Glorieux FH, et al. Bone histomorphometry: standardisation of nomenclature, symbols, and units. J Bone Miner Res 1987; 2: 595-610.
37. Torricelli P, Fini M, Rocca M, Giavaresi G, Giardino R. In vitro pathological model of osteopenia to test orthopaedic biomaterials. Art Cells, Blood Subs, and Immob Biotech (In press).
38. Meunier PJ. Bone histomorphometry. In: Riggs BL, Melton U III, eds. Osteoporosis: etiology, diagnosis and management. Philadelphia: Lippincott Raven Publisher, 1995; 299-318.
39. Marotti G. The original contributions of the scanning electron microscopy to the knowledge of bone structure. In: Bonucci E, Motta PM, eds. Ultrastructure of skeletal tissues. Bone and cartilage in health and disease. Boston: Kluwer Academic Publisher, 1990; 19-39.
40. Nordin BE. Calcium and osteoporosis. Nutrition 1997; 13: 664-86.
41. Chavassieux P, Pastoureau P, Chapuy MC, Delmas PD, Meunier PJ. Glucocorticoid-induced inhibition of osteoblastic bone formation in ewes: a biochemical and histomorphometric study. Osteoporosis Int 1993; 3: 97-102.