A new nonpeptide tachykinin NK1 receptor antagonist isolated from the plants of compositae

Chemical and Pharmaceutical Bulletin

Volumn 50, Issue 1, 2002, Pages 47-52

  Yamamoto, Atsushi ^a   Nakamura, Ko ^a   Furukawa, Kazuhito ^a   Konishi, Yukari ^a   Ogino, Takashi ^a   Higashiura, Kunihiko ^a   Yago, Hisashi ^a   Okamoto, Kaoru ^a   Otsuka, Masanori ^a  

^a Nippon Zoki Pharmaceutical Co   (Japan)

Author keywords

Chamomile; Compositae; Matricaria chamomilla; NK1; Tachykinin antagonist

Indexed keywords

MATRICARIA CHAMOMILLA EXTRACT; N1,N5,N10 TETRAKIS[3 (4 HYDROXYPHENYL) 2 PROPENOYL] 1,5,10 TRIAZADECANE; N1,N5,N10 TETRAKIS[3 (4 HYDROXYPHENYL) 2 PROPENOYL] 1,5,10,14 TETRAAZATETRADECANE; N1,N5,N10,N14 TETRAKIS[3 (2 HYDROXYPHENYL) 2 PROPENOYL] 1,5,10,14 TETRAAZATETRADECANE; N1,N5,N10,N14 TETRAKIS[3 (3 HYDROXYPHENYL) 2 PROPENOYL] 1,5,10,14 TETRAAZATETRADECANE; N1,N5,N10,N14 TETRAKIS[3 (3,4 DIHYDROXYPHENYL) 2 PROPENOYL] 1,5,10,14 TETRAAZATETRADECANE; N1,N5,N10,N14 TETRAKIS[3 (4 HYDROXYPHENYL) 2 METHYL 2 PROPENOYL] 1,5,10,14 TETRAAZATETRADECANE; N1,N5,N10,N14 TETRAKIS[3 (4 HYDROXYPHENYL) 2 PROPENOYL] 1,5,10,14 TETRAAZA 7 TETRADECANE; N1,N5,N10,N14 TETRAKIS[3 (4 HYDROXYPHENYL) 2 PROPENOYL] 1,5,10,14 TETRAAZATETRADECANE; N1,N5,N10,N14 TETRAKIS[3 (4 HYDROXYPHENYL)PROPANOYL] 1,5,10,14 TETRAAZATETRADECANE; N1,N5,N9,N13 TETRAKIS[3 (4 HYDROXYPHENYL) 2 PROPENOYL] 1,5,9,13 TETRAAZATRIDECANE; SUBSTANCE P; TACHYKININ RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG; ALKENE; CHAMOMILE; HETEROCYCLIC COMPOUND; NEUROKININ 1 RECEPTOR; PLANT EXTRACT; TACHYKININ; TETRACOUMAROYL SPERMINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; DRUG ISOLATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; FLOWER; GUINEA PIG; ILEUM; MATRICARIA; MUSCLE CONTRACTION; NONHUMAN; POLLEN; STRUCTURE ACTIVITY RELATION; ANIMAL; ASTERACEAE; BINDING COMPETITION; CHEMISTRY; CHO CELL; DRUG ANTAGONISM; DRUG EFFECT; HAMSTER; HUMAN; ISOLATION AND PURIFICATION; METABOLISM;

ALKENES; ANIMALS; ASTERACEAE; AZA COMPOUNDS; BINDING, COMPETITIVE; CHAMOMILE; CHO CELLS; CRICETINAE; GUINEA PIGS; HUMANS; ILEUM; MUSCLE CONTRACTION; PLANT EXTRACTS; RECEPTORS, NEUROKININ-1; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTANCE P; TACHYKININS;

EID: 0036357951     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.50.47     Document Type: Article

References (18)

1. Snider R. M., Constantine J. W., Lowe J. A., III, Longo K. P., Lebel W. S., Woody H. A., Drozda S. E., Desai M. C., Vinick R J., Spencer R. W., Hess H.-J., Science, 251, 435-437 (1991).
2. Dietl M. M., Palacios J. M., Brain Research, 539, 211-222 (1991).
3. Otsuka M., Yoshioka K., Yanagisawa M., Suzuki F., Zhao F.-Y., Guo J.-Z., Hosoki R., Kurihara T., Can. J. Physiol. Pharmacol., 73, 903-907 (1994).
4. Kramer S. M., Cutler N., Feughner J., Shrivastava R., Carman J., Sramek J. J., Reines S. A., Liu G., Snavely D., Wyatt-Knowles E., Hale J. J., Mills S. G., MacCoss M., Swain C. J., Harrison T., Hill R. G., Hefti F., Scolnick E. M., Cascieri M. A., Chicehi G. C., Swadowski S., Williams A. R., Hewson L., Smith D., Calson E. J., Hargreaves R. J., Rupniak M. J., Science, 281, 1640-1645 (1998).
5. Hashimoto M., Hayashi K., Murai M., J. Antibiot., 45, 1064-1070 (1992).
6. Colin J. B., Hao H. S., J. Nat. Prod., 57, 471-476 (1994).
7. Yamamoto A., Nakamura K., Otsuka M., Japan Kokai Tokkyo Koho, P2000-256293A (2000).
8. Murakoshi I., Sugimoto K., Haginiwa J., Ohmiya S., Otomasu H., Phytochemistry, 14, 2714-2715 (1975).
9. Moeller H., Bartnik F., Banduhn N., Ger. Offen., DE 4033565 (1992).
10. Babin P., Lapouyade P., Dunogues J., Can. J. Chem., 60, 379-382 (1982).
11. Oinuma H., Takamura T., Hasegawa T., Nomoto K., Naitoh T., Daiku Y., Hamano S., Kakisawa H., Minami N., J. Med. Chem., 34, 2260-2267 (1991).
12. Naaasaka T., Momose K., Hamaguchi F., Yamada K., Suzuki Y., Yakugaku Zasshi, 112, 100-107 (1992).
13. Quick J., Crelling J. K., J. Org. Chem., 43, 155-156 (1978).
14. Natsugari H., Ikeura Y., Kiyota Y., Ishichi Y., Ishimaru T., Saga O., Shirafuji H., Tanaka T., Kamo I., Doi T., Otsuka M., J. Med. Chem., 38, 3106-3120 (1995).
15. Regoli D., Drapeau G., Dion S., Couture R., Trends Pharmacol. Sci., 9, 290-295 (1988).
16. Saito K., Horie M., Nose N., Nakagomi K., Nakazawa H., Anal. Sci., 8, 675-680 (1992).
17. Hosoki R., Yanaeisawa M., Onishi Y., Yoshioka K., Otsuka M., Eur. J. Phramacol., 341, 235-241 (1998).
18. Nakajima Y., Tsuchida K., Ncgishi M., Ito S., Nakanishi S., J. Biol. Chem., 267, 2437-2442 (1992).