Membrane stabilizer: Citicoline

Current Medical Research and Opinion

Volumn 18, Issue SUPPL. 2, 2002, Pages

  Zweifler, Richard M ^a  

^a UNIVERSITY OF SOUTH ALABAMA   (United States)

Author keywords

CDP choline; Citicoline; Stroke; Treatment

Indexed keywords

CITICOLINE; NOOTROPIC AGENT;

ANIMAL; CELL MEMBRANE; CEREBROVASCULAR ACCIDENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DRUG EFFECT; EUROPE; HUMAN; JAPAN; RANDOMIZED CONTROLLED TRIAL; REVIEW; UNITED STATES;

ANIMALS; CELL MEMBRANE; CEREBROVASCULAR ACCIDENT; CYTIDINE DIPHOSPHATE CHOLINE; EUROPE; HUMANS; JAPAN; NOOTROPIC AGENTS; RANDOMIZED CONTROLLED TRIALS; UNITED STATES;

EID: 0036357196     PISSN: 03007995     EISSN: 14734877     Source Type: Journal    
DOI: 10.1185/030079902125000679     Document Type: Article

References (20)

1. Weiss GB. Minireview: metabolism and actions of CDP-choline as an endogenous compound and administered exogenously as citicoline. Life Sci 1995;56:637-60
2. D'Orlando KJ, Sandage BW. Citicoline (CDP-choline): mechanisms of action and effects in ischemic brain injury. Neurol Res 1995;17:281-4
3. Savci V, Wurtman RJ. Effect of cytidine on membrane phospholipid synthesis in rat striatal slices. J Neurochem 1995;64:378-84
4. Dorman R.V, Dabrowiecki Z, Horrocks L.A. Effects of CDP choline and CDP ethanolamine on the alterations in rat brain lipid metabolism induced by global ischemia. J Neurochem 1983;40:276-9
5. Horrocks L.A, Dorman RV, Dabrowiecki Z. et al. CDP-choline and CDP-ethanolamine prevent the release of free fatty acids during brain ischemia. Prog Lipid Res 1981;20:531-4
6. Tovarelli G, De Medio G.E, Dorman RV, et al. Effect of cytidine diphosphate choline (CDP-choline) on ischemia-induced alterations of brain lipid in the gerbil. Neurochem Res 1981;6:821-33
7. Obeid L.M, Linardic CM, Karolak LA, et al. Programmed cell death induced by ceramide. Science 1993;259: 1769-71
8. Lopez-Coviella I, Clark WM, Warach S, et al. CDP-choline (citicoline): potential mechanisms of action and preliminary results in human stroke. In Goldstein LB, ed. Restorative Neurology: Advances in Pharmacotherapy for Recovery after Stroke. Armonk: Futura, 1998;195-212
9. Boismare F, Le Poncin LM, Rapin JR. Hemodynamic, functional, and biochemical effects of hypobaric hypoxia in rats treated with cytidine diphosphocholine. Presented at the Comptes Rendus des Séances de la Société de Biologie, 1978;172:651
10. Kakihana M, Fukuda N, Suno M. et al. Effects of CDP-choline on neurologic deficits and cerebral glucose metabolism in a rat model of cerebral ischemia. Stroke 1988;19:217-22
11. Mykita S, Golly F, Dreyfus H, et al. Effect of CDP-choline on hypocampic neurons in culture. J Neurochem 1986;47: 223-31
12. Aronowski J, Strong R, Grotta JC. Citicoline for treatment of experimental focal ischemia: Histologic and behavioral outcome. Neurol Res 1996;18:570-4
13. Boudouresques AB, Michel B. Therapeutic conduct in light of a cerebral vascular accident and the use of CDP-choline. Presented at the International Symposium: Brain Suffering and Precursors of Phospholipids, Paris, January 18, 1980
14. Goyas JY, Bastard J, Missoum A. Therapeutic conduct in light of a cerebral vascular accident and the use of CDP-choline. Presented at the International Symposium: Brain Suffering and Precursors of Phospholipids, Paris, January 18, 1980
15. Corso A, Arena M, Ventimiglia A, et al. CDP-choline for cerebrovascular disorders: clinical evaluation and evaluation of electrophysiological symptomology. CL Terap 1982;102:379-86
16. Tazaki Y, Sakai F, Otomo E, et al. Treatment of acute cerebral infarction with a choline precursor in a multicenter double-blind placebo-controlled study. Stroke, 1988;19: 211-16
17. Clark WM, Warach SJ, Pettigrew LC, et al. A randomized dose-response trial of citicoline in acute ischemic stroke patients. Neurology 1997;49:671-8
18. Clark WM, Williams BJ, Selzer KA, et al. A randomized efficacy trial of citicoline in patients with acute ischemic stroke. Stroke 1999;30:2592-7
19. Clark WM, Wechsler LR, Sabounjian LA, et al. A phase III randomized efficacy trial of citicholine in acute ischemic stroke patients. Neurology 2001;57:1595-1602
20. Warach S, Pettigrew LC, Dashe JF, et al. Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging. Ann Neurol 2000; 48:713-22