Increased expression of p21WAF-1/CIP-1 in the lens epithelium of rat sugar cataract

Experimental Eye Research

Volumn 74, Issue 2, 2002, Pages 245-254

  Takamura, Yoshihiro ^a   Kubo, Eri ^a   Tsuzuki, Shousai ^a   Yagi, Hideshi ^a   Sato, Makoto ^a   Akagi, Yoshio ^a  

^a UNIVERSITY OF FUKUI   (Japan)

Author keywords

Cataract; Cell cycle; Galactose; Lens; Lens epithelial cells; Multi layered epithelium; p21; p21 WAF 1; p21CIP 1; PCNA; Proliferation

Indexed keywords

BIOLOGICAL MARKER; CYCLINE; MESSENGER RNA; PROTEIN P21;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATARACT; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; DIET; DISEASE COURSE; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; LENS EPITHELIUM; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; RAT;

EID: 0036351448     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1006/exer.2001.1120     Document Type: Article

References (35)

1. Aldose reductase mRNA is an epithelial cell-specific gene transcript in both normal and cataractous rat lens
2. Identification and isolation from bovine epithelial lens cells of two basic fibroblast growth factor receptors that process bFGF-enhanced phosphorylation activities
3. Induction of cell cycle entry and cell death in postmitotic lens fiber cells by overexpression of E2F1 or E2F2
4. Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism
5. WAF1, a potential mediator of p53 tumor suppression
6. The response of the lens to trauma
7. Cdk-interacting protein I directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme
8. Lens epithelium proliferation in sugar cataracts
9. Intravitreal injection of TGF-beta induces cataract in rats
10. Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: An index of cell proliferation with evidence of deregulated expression in some neoplasms
11. Inhibition of cyclin-dependent kinases by p21
12. p21(WAF1/CIP1) expression in stage 1 cutaneous malignant melanoma: Its relationship with p53, cell proliferation and survival
13. PCNA: Structure, functions and interactions
14. Mesoderm induction in Xenopus is a zygotic event regulated by maternal VegT via TGFβ growth factors
15. Developmental and spatial patterns of expression of the mouse homeobox gene, Hox 2.1
16. Cell growth of rat lens epithelium in galactose-induced cataracts
17. Role of transforming growth factor-β in transdifferentiation and fibrosis of lens epithelial cells
18. E2F1 mediates ectopic proliferation and stage-specific p53-dependent apoptosis but not aberrant differentiation in the ocular lens of Rb deficient fetuses
19. Cell-biological analysis of atopic cataractous lenses
20. Disruption of retinoblastoma protein family function by HPV-16 E7 inhibits lens development in part through E2F-1
21. Induction of WAF1/CIP1 by a p53-independent pathway
22. p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens
23. Quantitative analysis of gene amplification in insecticide-resistant Culex mosquitoes
24. Mechanism of inhibition of proliferating cell nuclear antigen-dependent DNA synthesis by the cyclin-dependent kinase inhibitor p21
25. Chemotactic activity in aqueous humor from patients with anterior uveitis
26. The proliferative ability of the lens epithelium in rat galactose cataracts. Examination using whole-mount preparations
27. Changes in cyclin/proliferating cell nuclear antigen distribution during DNA repair synthesis
28. waf-1 in human cutaneous squamous cell carcinoma
29. waf-1/CIP1 in human cutaneous malignant melanoma
30. Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos
31. The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
32. The retinoblastoma protein and cell cycle control
33. Expression of c-myc protooncogene in rat lens cells during development, maturation and reversal of galactose cataracts
34. WAF/CIP1 expresion by p53-independent pathways