New insights into the clinical pharmacokinetics of trofosfamide

International Journal of Clinical Pharmacology and Therapeutics

Volumn 40, Issue 8, 2002, Pages 376-381

  Brinker, A ^a   Kisro, J ^a   Letsch, C ^a   Bruggemann S K ^a   Wagner, T ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Bioavailability; Metabolites; Pharmacokinetics; Trofosfamide

Indexed keywords

2 DECHLOROETHYLIFOSFAMIDE; 3 DECHLOROETHYLIFOSFAMIDE; BILIRUBIN; CHOLINESTERASE; CREATININE; CYCLOPHOSPHAMIDE; CYTOSTATIC AGENT; DRUG METABOLITE; IFOSFAMIDE; OXAZAPHOSPHORINE DERIVATIVE; TROFOSFAMIDE; UNCLASSIFIED DRUG;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG DISPOSITION; DRUG HALF LIFE; DRUG METABOLISM; FEMALE; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROXYLATION; MALE; MOLECULAR STABILITY; NONHODGKIN LYMPHOMA; QUANTITATIVE ASSAY; SOLID TUMOR; URINARY EXCRETION;

EID: 0036330225     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: 10.5414/CPP40376     Document Type: Article

References (26)

1. Fluorometric determination of acrolein and related compounds with m-aminophenol
2. Clinical pharmacology of cyclophosphamide
3. Oral trofosfamide: An active drug in the treatment of soft-tissue sarcoma
4. Metabolism and pharmacokinetics of oxazaphosphorines
5. High-performance liquid chromatographic determination of acrolein as a marker for cyclophosphamide bioactivation in human liver microsomes
6. Trofosfamide metabolism in different species - Ifosfamide is the predominant metabolite
7. Metabolism of ifosfamide to chloroacetaldehyde contributes to antitumor activity in vivo
8. Pharmacologic studies with trophosphamide (Ixoten, a new oxazaphosphorine oxide)
9. Ifosfamide cytotoxicity on human tumor and renal cells: Role of chloroacetaldehyde in comparison to 4-hydroxy-ifosfamide
10. Bioavailability of ifosfamide in patients with bronchial carcinoma
11. Saturable metabolism of continuous high-dose ifosfamide with mesna and GM-CSF: A pharmacokinetic study in advanced sarcoma patients
12. Pharmacokinetics and pharmacodynamic data analysis for the PC
13. Pharmacokinetics of trofosfamide and its dechloro-ethylated metabolites
14. Determination of 4-hydroxy-ifosfamide in biological matrices by high-performance liquid chromatography
15. Ifosfamide metabolism and pharmacokinetics
16. Comparative pharmacokinetics of ifosfamide, 4-hydroxyifosfamide, chloroacetaldehyde
17. Ifosfamide pharmacokinetics and neurotoxicity
18. Palliative chemotherapy in non-Hodgkin's lymphoma
19. Repeated high-dose cyclophosphamide administration in bone marrow transplantation: Exposure to activated metabolites
20. Ifosfamide, mesna and nephrotoxicity in children
21. Pharmacokinetics and bioavailability of cyclophosphamide from oral formulations
22. Trofosfamide: A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the oral treatment of cancer
23. Pharmacokinetics and bioavailability of oral ifosfamide
24. Ifosfamide clinical pharmacokinetics
25. Two oral trofosfamide schedules in elderly patients with refractory non-Hodgkin's lymphoma
26. Oral trofosfamide and etoposide in pediatric patients with glioblastoma multiforme