Enhanced engraftment of EPO-transduced human bone marrow stromal cells transplanted in a 3D matrix in non-conditioned NOD/SCID mice

Gene Therapy

Volumn 9, Issue 14, 2002, Pages 915-921

  Daga, A ^a   Muraglia, A ^a   Quarto, R ^a   Cancedda, R ^a   Corte, G ^a  

^a CENTRO DI BIOTECNOLOGIE AVANZATE   (Italy)

Author keywords

Bone marrow stroma; Engraftment; Gene therapy

Indexed keywords

ERYTHROPOIETIN;

ANIMAL EXPERIMENT; ARTICLE; BONE MARROW TRANSPLANTATION; CELL LOSS; CONTROLLED STUDY; ENDOTHELIUM; FEMALE; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENE THERAPY; GENETIC CODE; GENETIC TRANSDUCTION; HEMATOCRIT; HEMATOPOIESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECIPIENT; RETROVIRUS; SCID MOUSE; STROMA CELL; THREE DIMENSIONAL IMAGING;

ADIPOCYTES; ANIMALS; BONE AND BONES; BONE MARROW TRANSPLANTATION; CELL DIFFERENTIATION; CHONDROCYTES; ERYTHROPOIETIN; FEMALE; GENE THERAPY; GENETIC VECTORS; INFUSIONS, INTRAVENOUS; INJECTIONS, SUBCUTANEOUS; MICE; MICE, SCID; RETROVIRIDAE; STROMAL CELLS; TRANSDUCTION, GENETIC; TRANSPLANTATION, HOMOLOGOUS;

ANIMALIA; UNIDENTIFIED RETROVIRUS;

EID: 0036328073     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301727     Document Type: Article

References (19)

1. Marrow stromal stem cells
2. Bone marrow stromal stem cells: Nature, biology, and potential applications
3. Cells capable of bone production engraft from whole bone marrow transplants in nonablated mice
4. Long-term cytokine production from engineered primary human stromal cells influences human hematopoiesis in an in vivo xenograft model
5. Bone marrow-derived mesenchymal stem cells remain host-derived despite successful hematopoietic engraftment after allogeneic transplantation in patients with lysosomal and peroxisomal storage diseases
6. Stromal damage as consequence of high-dose chemo/radiotherapy in bone marrow transplant recipients
7. Limited engraftment capacity of bone marrow-derived mesenchymal cells following T cell-depleted hematopoietic stem cell transplantation
8. LacZ and interleukin-3 expression in vivo after retroviral transduction of marrow-derived human osteogenic mesenchymal progenitors
9. Long-term persistence of human bone marrow stromal cells transduced with factor VIII-retroviral vectors and transient production of therapeutic levels of human factor VIII in nonmyeloablated immunodeficient mice
10. Stem cell transplantation in the normal nonmyeloablated host: Relationship between cell dose, schedule, and engraftment
11. Lymphohematopoietic engraftment in minimally myeloablated hosts
12. Gene therapy for long-term expression of erythropoietin in rats
13. Baboon mesenchymal stem cells can be genetically modified to secrete human erythropoietin in vivo
14. Clonal mesenchymal progenitors from human bone marrow differentiate in vitro according to a hierarchical model
15. A safe packaging line for gene transfer: Separating viral genes on two different plasmids
16. Construction and use of a safe and efficient amphotropic packaging cell line
17. High-efficiency gene transfer into mammalian cells: Generation of helper-free recombinant retrovirus with broad mammalian host range
18. In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells
19. A nude mouse model for human bone formation in unloaded conditions