AT1 receptor blockade increases cardiac bradykinin via neutral endopeptidase after induction of myocardial infarction in rats

FASEB Journal

Volumn 16, Issue 10, 2002, Pages 1237-1241

  Walther, Thomas ^a,c   Siems, Wolf E ^b   Hauke, Dorian ^a   Spillmann, Frank ^a   Dendorfer, Andreas ^a   Krause, Winfried ^a   Schultheiss, Heinz Peter ^a   Tschöpe, Carsten ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b UNIVERSITY OF LÜBECK   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Bradykinin; Enzymes; Hemodynamics; Inhibitors; Neutral endopeptidase; Renin angiotensin system

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; BRADYKININ; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; IRBESARTAN; PROTEINASE; QUINAPRIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEGRADATION; DISEASE ASSOCIATION; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME METABOLISM; HEART INFARCTION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEMODYNAMICS; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; BIPHENYL COMPOUNDS; BRADYKININ; HEMODYNAMIC PROCESSES; ISOQUINOLINES; MALE; MYOCARDIAL INFARCTION; MYOCARDIUM; NEPRILYSIN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTORS, ANGIOTENSIN; TETRAHYDROISOQUINOLINES; TETRAZOLES;

ANIMALIA;

EID: 0036325859     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.01-0641com     Document Type: Article

References (18)

1. Mammalian membrane metallopeptidases: NEP, ECE, KELL, and PEX
2. Effect on prolonged inhibition of neutral endopeptidase on cardiac hypertrophy in rats with myocardial infarction
3. Vasopeptidase inhibition with omapatrilat improves cardiac geometry and survival in cardiomyopathic hamsters more than does ACE inhibition with captopril
4. Myocardial bradykinin B2 receptor expression at different time points after induction of myocardial infarction
5. Effect of ethanol drinking on the gene expression of opioid receptors, enkephalinase, and angiotensin-converting enzyme in two inbred mice strains
6. Is bradykinin a mediator of renal neuropeptide Y effects?
7. Insufficient secretion of atrial natriuretic peptide at acute phase of myocardial infarction
8. Changes in components of kinin system and hemodynamic in acute myocardial infarct
9. Up-regulation of bradykinin B1 receptor expression after myocardial infarction
10. Antihypertensive and cardioprotective effects after angiotensin-converting enzyme inhibition: Role of kinins
11. Effect of neutral endopeptidase 24.11 inhibition on myocardial ischemia/reperfusion injury: The role of kinins
12. Effect of angiotensinconverting enzyme inhibitors and angiotensin II type 1 receptor antagonists in rats with heart failure
13. Infarct size reduction by AT1 receptor blockade through a signal cascade of AT2 receptor activation, bradykinin and prostaglandins in pigs
14. Angiotensin II type 2 receptor overexpression activates the vascular kinin system and causes vasodilation
15. Regulation of gene transcription of angiotensin II receptor subtypes in myocardial infarction
16. Effects of the vasopeptidase inhibitor omaprilat on cardiac endogenous kinins in rats with acute myocardial infarction
17. Kallidin- and bradykinin-degrading pathways in human heart: Degradation of kallidin by aminopeptidase M-like activity and bradykinin by neutral endopeptidase
18. Multiple interactions between the renin-angiotensin and the kallikreinkinin systems: Role of ACE inhibition and AT1 receptor blockade