T cell receptor transgenic mice recognizing the immunodominant epitope of the Torpedo california acetylcholine receptor

European Journal of Immunology

Volumn 32, Issue 7, 2002, Pages 2055-2067

  Lobito, Adrian A ^a   Yang, Bingzhi ^b   Lopes, Marcela F ^a   Miagkov, Alexei ^b   Adams, Robert N ^b   Palardy, Gregory R ^a   Johnson, Michele M ^a   McFarland, Hugh I ^a   Recher, Michael ^c   Drachman, Daniel B ^b   Lenardo, Michael J ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c INSTITUTE OF EXPERIMENTAL IMMUNOLOGY   (Switzerland)

Author keywords

Antibody; B cell; Experimental autoimmune myasthenia gravis; Myasthenia gravis; TCR transgenic

Indexed keywords

CHOLINERGIC RECEPTOR; EPITOPE; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; BLOOD CELL; CONTROLLED STUDY; DISEASE SEVERITY; IMMUNIZATION; INCIDENCE; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; MOLECULAR RECOGNITION; MOUSE; MYASTHENIA GRAVIS; NEUROMUSCULAR SYNAPSE; NONHUMAN; PATHOGENESIS; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; SPLEEN; T LYMPHOCYTE; T LYMPHOCYTE RECEPTOR GENE; TH1 CELL; TORPEDO CALIFORNICA; TRANSGENIC MOUSE; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIVISION; EPITOPES, T-LYMPHOCYTE; GENE EXPRESSION; IMMUNODOMINANT EPITOPES; LYMPHOCYTE COUNT; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MYASTHENIA GRAVIS, AUTOIMMUNE, EXPERIMENTAL; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, CHOLINERGIC; TORPEDO; VESICULAR STOMATITIS-INDIANA VIRUS;

EID: 0036319266     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200207)32:7<2055::AID-IMMU2055>3.0.CO;2-Q     Document Type: Article

References (61)

1. Myasthenia gravis and other diseases of the neuromuscular junction
2. Neuromuscular junction in myasthenia gravis: Decreased acetylcholine receptors
3. Serum globulin in Myasthenia gravis: Inhibition of α-bungarotoxin binding to acetylcholine receptors
4. Myasthenia gravis. Study of humoral immune mechanisms by passive transfer to mice
5. Antibody to acetylcholine receptor in myasthenia gravis. Prevalence, clinical correlates, and diagnostic value
6. Mechanisms of acetylcholine receptor loss in myasthenia gravis
7. Functional activities of autoantibodies to acetylcholine receptors and the clinical severity of myasthenia gravis
8. Myasthenic immunoglobulin accelerates acetylcholine receptor degradation
9. Accelerated degradation and acetylcholine receptor from cultured rat myotubes with myasthenia gravis sera and globulins
10. Myasthenic antibodies cross-link acetylcholine receptors to accelerate degradation
11. The membrane attack complex of complement at the endplate in myasthenia gravis
12. Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies
13. Autoimmune response to acetylcholine receptor
14. Endplate potentials in experimental autoimmune myasthenia gravis in rats
15. Antibodies to acetylcholine receptors in rabbits: Immunological and electrophysiological studies
16. Experimental autoimmune myasthenia gravis: Induction and treatment
17. Strain differences in the autoimmune response of mice to acetylcholine receptors
18. Factors affecting the susceptibility of different strains of mice to experimental myasthenia gravis
19. Immunogenetics of experimental autoimmune myasthenia gravis
20. Experimental autoimmune myasthenia gravis: Cellular and humoral immune responses
21. Cellular immunity to acetylcholine receptor in myasthenia gravis: Relationship to histocompatibility type and antigenic site
22. Acetylcholine receptor-specific human T-lymphocyte lines
23. T cell reactivity in myasthenia gravis
24. + cell lines from myasthenia gravis patients
25. In vitro proliferative responses and antibody titers specific to human acetylcholine receptor synthetic peptides in patients with myasthenia gravis and relation to HLA class II genes
26. Amphipathic segment of the nicotinic receptor alpha subunit contains epitopes recognized by T lymphocytes in myasthenia gravis
27. Autoimmune T cell recognition of human acetylcholine receptor: The sites of T cell recognition in myasthenia gravis on the extracellular part of the alpha subunit
28. Immunological heterogeneity of autoreactive T lymphocytes against the nicotinic acetylcholine receptor in myasthenic patients
29. T cell antigenic sites involved in myasthenia gravis: Correlations with antibody titre and disease severity
30. T cells from normal and myasthenic individuals recognize the human acetylcholine receptor: Heterogeneity of antigenic sites on the alpha-subunit
31. T-helper epitopes on human nicotinic acetylcholine receptor in myasthenia gravis
32. Localization of the functional sites on the alpha chain of acetylcholine receptor
33. T cell responses in EAMG-susceptible and non-susceptible mouse strains after immunization with overlapping peptides encompassing the extracellular part of Torpedo californica acetylcholine receptor alpha myasthenia gravis of autoimmune T cell responses against receptor degradation responses
34. + cells sensitized to nicotinic acetylcholine receptor
35. Determinant selection in murine experimental autoimmune myasthenia gravis. Effect of the bm12 mutation on T cell recognition of acetylcholine receptor epitopes
36. Mutation at I-A beta chain prevents experimental autoimmune myasthenia gravis
37. Effect of amino acid substitutions within the region 62-76 of I-A beta b on binding with and antigen presentation of Torpedo acetylcholine receptor alpha-chain peptide 146-162
38. How subtle differences in MHC class II affect the severity of experimental myasthenia gravis
39. Suppression of experimental autoimmune myasthenia gravis by epitope-specific neonatal tolerance to synthetic region alpha 146-162 of acetylcholine receptor
40. Restricted T cell receptor repertoire for acetylcholine receptor in murine myasthenia gravis
41. TCR gene usage in experimental autoimmune myasthenia gravis pathogenesis. Usage of multiple TCRBV genes in the H-2b strains
42. A disease-related epitope of Torpedo acetylcholine receptor. Residues involved in I-Ab binding, self-nonself discrimination, and TCR antagonism
43. Cassette vectors directing expression of T cell receptor genes in transgenic mice
44. Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity
45. Cytotoxic T lymphocytes to an unmutated tumor rejection antigen P1A: Normal development but restrained effector function in vivo
46. A transgenic model of autoimmune hemolytic anemia
47. Following a diabetogenic T cell from genesis through pathogenesis
48. Organ-specific disease provoked by systemic autoimmunity
49. From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins
50. Preferential use of a T cell receptor V beta gene by acetylcholine receptor reactive T cells from myasthenia gravis-susceptible mice
51. Highly conserved TCR beta chain CDR3 sequences among immunodominant acetylcholine receptor-reactive T cells in murine myasthenia gravis
52. IL-12 is involved in the induction of experimental autoimmune myasthenia gravis, an antibody-mediated disease
53. Absence of IFN-gamma or IL- 12 has different effects on experimental myasthenia gravis in C57BL/6 mice
54. Interleukin-12 enhances clinical experimental autoimmune myasthenia gravis in susceptible but not resistant mice
55. Muscle acetylcholine receptor loss in murine experimental autoimmune myasthenia gravis: Correlated with cellular, humoral and clinical responses
56. Role of acetylcholine receptor antibody complexes in muscle in experimental autoimmune myasthenia gravis
57. Experimental autoimmune myasthenia gravis induction in B cell-deficient mice
58. Purification and molecular properties of the acetylcholine receptor from Torpedo electroplax
59. Tolerance to acetylcholine receptor induced by AChR-coupled syngeneic cells
60. Pathological mechanisms in experimental autoimmune myasthenia gravis1: Immunogenicity of syngeneic muscle acetylcholine receptor and quantitative extraction of receptor and antibody-receptor complexes of experimental autoimmune myasthenia gravis
61. Antiviral protection and germinal center formation, but impaired B cell memory in the absence of CD19