Congenital heart block in neonatal lupus: The pediatric cardiologist's perspective

Indian Journal of Pediatrics

Volumn 69, Issue 6, 2002, Pages 517-522

  Friedman, Deborah M ^a   Rupel, Ann ^b   Glickstein, Julie ^c   Buyon, Jill P ^b  

^a ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

^b NYU HOSPITAL FOR JOINT DISEASES   (United States)

^c Columbia University College of Physicians and Surgeons ^*  (United States)

Author keywords

Congenital heart block; Fetal Doppler echocardiography; Neonatal lupus

Indexed keywords

DEXAMETHASONE; IMMUNOGLOBULIN G ANTIBODY; LA ANTIBODY; MATERNAL ANTIBODY; RHESUS ANTIBODY; RIBONUCLEOPROTEIN; RO ANTIBODY; UNCLASSIFIED DRUG;

ANTIBODY DETECTION; BRADYCARDIA; CELL SURFACE; CHILDBIRTH; CLINICAL TRIAL; CONFERENCE PAPER; CONGENITAL HEART BLOCK; DISEASE SEVERITY; DOPPLER ECHOGRAPHY; EARLY DIAGNOSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FETUS ECHOGRAPHY; FETUS HYDROPS; GESTATIONAL AGE; HIGH RISK PATIENT; HUMAN; IMMUNIZATION; INFLAMMATION; LUPUS ERYTHEMATOSUS; M MODE ECHOCARDIOGRAPHY; MAJOR CLINICAL STUDY; MOLECULAR RECOGNITION; MORTALITY; NEWBORN; NEWBORN DISEASE; PATHOGENESIS; PR INTERVAL; PRACTICE GUIDELINE; SURVIVAL;

ANTIBODIES, ANTINUCLEAR; AUTOIMMUNE DISEASES; FEMALE; HEART BLOCK; HUMANS; INFANT, NEWBORN; LUPUS; PREGNANCY; PREGNANCY COMPLICATIONS, CARDIOVASCULAR;

EID: 0036318164     PISSN: 00195456     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02722656     Document Type: Article

References (38)

1. Neonatal lupus syndromes
2. Neonatal lupus erythematosus
3. Autoimmune-associated congenital heart block: Mortality, morbidity, and recurrence rates obtained from a national neonatal lupus registry
4. Congenital complete atrioventricular block
5. Congenital heart block: Development of late-onset cardiomyopathy, a previously underappreciated sequela
6. A new therapeutic approach to the fetus with congenital complete heart block: Preemptive, targeted therapy with dexamethasone
7. Cutaneous manifestations of neonatal lupus without heart block: Characteristics of mothers and children enrolled in a national registry
8. Thrombocytopenia in the neonatal lupus syndrome
9. Neonatal lupus manifests as isolated neutropenia and mildly abnormal liver functions
10. Liver disease in neonatal lupus erythematosus
11. Hepatobiliary disease in neonatal lupus: Prevalence and clinical characteristics in cases enrolled in a national registry
12. Neonatal hemochromatosis associated with maternal autoantibodies against Ro/SS-A and La/SS-B ribonucleoproteins
13. Anti-SS-A antibodies and fetal outcome in maternal systemic lupus erythematosus
14. Neonatal risk to newborns of mothers with systemic lupus erythematosus
15. Risk of congenital complete heart block in newborns of mothers with anti-Ro/SSA antibodies detected by counterimmunoelectrophoresis: A prospective study of 100 women
16. The rate of recurrence of isolated congenital heart block: A population-based study
17. Immunology and immunopathology of the maternofetal interface
18. Connective-tissue disease, antibodies to ribonucleoprotein, and congenital heart block
19. Pivotal role of human fetal cardiac fibroblasts in the pathogenesis of autoantibody-associated congenital heart block [abstract]
20. Accessibility of SSA/Ro and SSB/La antigens to maternal autoantibodies in apoptotic human fetal cardiac myocytes
21. Anti-SSA/Ro and -SSB/La autoantibodies bind the surface of apoptotic fetal cardiocytes and promote secretion of tumor necrosis factor α by macrophages
22. Induction of antibodies reactive with SSA/Ro-SSB/La and development of congenital heart block in a murine model
23. Serum and IgG from the mother of a child with congenital heart block induce conduction abnormalities and inhibit L-type calcium channels in a rat heart model
24. Identification of mothers at risk for congenital heart block and other neonatal lupus syndromes in their children: Comparison of ELISA and immunoblot to measure anti-SSA/Ro and anti-SSB/La antibodies
25. Comparison of treatment with fluorinated glucocorticoids to the natural history of autoantibody-associated congenital heart block: Retrospective review of the Research Registry for Neonatal Lupus
26. Intrauterine therapy for presumptive fetal myocarditis with acquired heart block due to systemic lupus erythematosus. Experience in a mother with a predominance of SS-B (La) antibodies
27. Autoantibody-associated congenital heart block: Outcome in mothers and children
28. In vitro metabolism of prednisolone, dexamethasone, betamethasone, and cortisol by the human placenta
29. Neonatal lupus erythematosus: Results of maternal corticosteroid therapy
30. Fetal echocardiography in the assessment of lupus pregnancies
31. Pulsed Doppler echocardiographic assessment of the fetal PR interval
32. Validation of the Doppler PR interval in the fetus
33. Therapeutic trial of sympathomimetics in three cases of complete heart block in the fetus
34. Diagnosis, management and outcome of congenital atrio-ventricular block
35. The presence of IgG antibodies reactive with components of the SSA/Ro-SSB/La complex in human breast milk: Implications in neonatal lupus