Blockade of cannabinoid CB1 receptor function protects against in vivo disseminating brain damage following NMDA-induced excitotoxicity

Journal of Neurochemistry

Volumn 82, Issue 1, 2002, Pages 154-158

  Hansen, Henrik H ^a,c   Azcoitia, Iñigo ^b,d   Pons, Sebastián ^d   Romero, Julián ^e   García Segura, Luis Miguel ^d   Ramos, José Antonio ^a   Hansen, Harald S ^c   Fernández Ruiz, Javier ^a,b  

^a Faculty of Medicine   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d INSTITUTO CAJAL   (Spain)

^e HOSPITAL UNIVERSITARIO FUNDACIÓN ALCORCÓN   (Spain)

Author keywords

CB1 receptor; Excitotoxicity; N methyl D aspartate; Neurodegeneration, neuroprotection; SR141716A

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; LIGAND; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RIMONABANT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; BRAIN INFARCTION; BRAIN INJURY; BRAIN PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; FOREBRAIN; NERVE CELL DEGENERATION; NEUROTOXICITY; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING;

ANIMALS; BRAIN; CANNABINOIDS; CELL SURVIVAL; CEREBRAL CORTEX; CORPUS STRIATUM; MORPHOLINES; N-METHYLASPARTATE; NAPHTHALENES; NEURODEGENERATIVE DISEASES; NEUROTOXINS; PARIETAL LOBE; PIPERIDINES; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB2; RECEPTORS, CANNABINOID; RECEPTORS, DRUG;

ANIMALIA;

EID: 0036317952     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.00961.x     Document Type: Article

References (26)

1. Neuroprotective effects of estradiol in the adult rat hippocampus: Interaction with insulin-like growth factor-I signalling
2. 9-tetrahydrocannabinol
3. 1 receptor
4. 2 receptors
5. Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation
6. Cannabinoids and neuroprotection
7. Formation of N-acyl-phosphatidylethanolamine and N-acylethanolamine (including anandamide) during glutamate-induced neurotoxicity
8. Accumulation of the anandamide precursor and other N-acylethanolamine phospholipids in infant rat models of in vivo necrotic and apoptotic neuronal cell death
9. Anandamide, but not 2-arachidonoylglycerol, accumulates during in vivo neurodegeneration
10. Sensitivity of the developing rat brain to hypobaric/ischemic damage parallels sensitivity to N-methyl-aspartate neurotoxicity
11. Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptors
12. Cannabinoids and brain injury: Therapeutic implications
13. 2 cannabinoid receptors in rat brain microglia and murine macrophage RAW 264.7 cells
14. 1 receptor antagonists are neuroprotective in focal cerebral ischemia-reperfusion injury
15. Cannabinoids and neuroprotection in global and focal cerebral ischemia and in neuronal cultures
16. An endogenous cannabinoid (2-AG) is neuroprotective after brain injury
17. 2 receptors
18. The endocannabinoid system as a target for therapeutic drugs
19. SR141716A, a potent and selective antagonist of the brain cannabinoid receptor
20. Anandamide induces apoptosis of PC-12 cells: Involvement of superoxide and caspase-3
21. Modulation of transmitter release via presynaptic cannabinoid receptors
22. Inhibitory effects of SR141716A on G-protein activation in rat brain
23. 9-tetrahydrocannabinol, the main active compound in marijuana, against ouabain-induced in vivo excitotoxicity
24. Exogenous anandamide protects rat brain against acute neuronal injury in vivo
25. Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses