Trastuzumab cardiotoxicity: Speculations regarding pathophysiology and targets for further study

Seminars in Oncology

Volumn 29, Issue 3 SUPPL. 11, 2002, Pages 22-28

  Schneider, Jay W ^a   Chang, Alice Y ^a   Garratt, Alistair ^a  

^a VA BOSTON HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRACYCLINE; MONOCLONAL ANTIBODY; NEU DIFFERENTIATION FACTOR; TRASTUZUMAB;

BREAST CANCER; CANCER CHEMOTHERAPY; CARDIOTOXICITY; CELL STRUCTURE; CELL SURFACE; CLINICAL TRIAL; CONFERENCE PAPER; DRUG POTENTIATION; DRUG SAFETY; DRUG TARGETING; GENE OVEREXPRESSION; HEART MUSCLE CELL; HUMAN; ONCOGENE NEU; PATHOPHYSIOLOGY; PATIENT SELECTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0036316232     PISSN: 00937754     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0093-7754(02)70123-1     Document Type: Conference Paper

References (17)

1. Radiolabeled antibody targeting of HER-2/neu oncoprotein
2. Autoantibody to p185erbB2/neu oncoprotein by vaccination with xenogenic DNA
3. Cardiotoxicity in signal transduction therapeutics: ErbB 2 antibodies and the heart
4. Agonistic antibodies stimulate the kinase encoded by the neu protooncogene in living cells but the oncogenic mutant is constitutively active
5. Trastuzumab and breast cancer
6. Principles of receptor-based inhibition of erbB family receptor kinases: Prospects for new therapies for human cancers
7. Expression of the p 185 encoded by HER2 oncogene in normal and transformed human tissues
8. Localization and modulation of ErbB receptor tyrosine kinases
9. Neuregulin receptors, erbB3 and erbB4 are localized at neuromuscular synapses
10. Conditional mutation of the erbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy
11. Multiple essential functions of neuregulin in development
12. Aberrant neural and cardiac development in mice lacking the erbB4 neuregulin receptor
13. Requirement for neuregulin receptor HER-2/erbB2 in neural and cardiac development
14. Neuregulins and their receptors: A versatile signaling module in organogenesis and oncogenesis
15. Neuregulin in cardiac hypertrophy in rats with aortic stenosis: Differential expression of erbB2 and erbB4 receptors
16. Effects by doxorubicin on the myocardium are mediated by oxygen free radicals
17. Trastuzumab in the treatment of metastatic breast cancer: Anticancer therapy versus cardiotoxicity