Autoantibody to p185erbB2/neu oncoprotein by vaccination with xenogenic DNA

Cancer Immunology, Immunotherapy

Volumn 43, Issue 5, 1997, Pages 307-315

  Concetti, Antonio ^a   Amid, Augusto ^a   Petrelli, Cristina ^a   Tibaldi, Alberto ^b   Provinciali, Mauro ^b   Venanzi, Franco Maria ^a  

^a Department of Biology MCA   (Italy)

^b INRCA   (Italy)

Author keywords

Autoantibodies; Breast cancer; DNA immunization; p185erbB2 neu

Indexed keywords

AUTOANTIBODY; DNA; ONCOPROTEIN; DNA VACCINE; EPIDERMAL GROWTH FACTOR RECEPTOR 2;

ADENOCARCINOMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; BREAST CANCER; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; INTRADERMAL DRUG ADMINISTRATION; INTRAMUSCULAR DRUG ADMINISTRATION; MALE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PASSIVE IMMUNIZATION; PRIORITY JOURNAL; VACCINATION; ANIMAL; B LYMPHOCYTE; BAGG ALBINO MOUSE; BREAST TUMOR; CELL CULTURE; CELL DIVISION; CROSS REACTION; EXPERIMENTAL NEOPLASM; IMMUNOLOGY; PATHOLOGY; RAT; SPECIES DIFFERENCE;

ANIMALS; AUTOANTIBODIES; B-LYMPHOCYTES; BREAST NEOPLASMS; CELL DIVISION; CROSS REACTIONS; FEMALE; HUMANS; MALE; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED BALB C; RATS; RECEPTOR, ERBB-2; SPECIES SPECIFICITY; TUMOR CELLS, CULTURED; VACCINES, DNA;

EID: 0030299805     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002620050338     Document Type: Article

References (38)

1. Bargmann CI, Hung MC, Weinberg RA (1986) Multiple independent activation of the neu oncogene by a point mutation altering the transmembrane domain of p185. Cell 45: 649
2. Bernards R, Destree A, McKenzie S, Gordon E, Weinberg RA, Panicali D (1987) Effective tumor immunotherapy directed against an oncogene-encoded product using a vaccina virus vector. Proc Natl Acad Sci USA 84: 6854
3. Cheever MA, Disis ML, Bernhard H, Gralow JR, Hand SL, Huseby ES, Qin HL, Takahashi M, Chen W (1995) Immunity to oncogenic proteins. Immunol Rev 145: 33
4. Chiller J, Habicht G, Weigle WO (1971) Kinetic differences in unresponsiveness of thymus and bone marrow cells. Science 171: 813
5. Davis HL, Whalen RG (1995) DNA-based immunization: In: Dixon G (ed) Molecular and cell biology of human gene therapeutics. Chapman & Hall, London, p 368
6. De Santes K, Slamon D, Anderson SK, Shepard M, Fendly B, Maneval D, Press O (1992) Radiolabeled antibody targetting of the HER-2/neu oncoprotein. Cancer Res 52: 1916
7. Di Fiore PP, Pierce JH, Kraus MH, Segatto O, King CR, Aaronson SA (1987) erbR-2 is a potent oncogene when overexpressed in NIH/3T3 cells. Science 237: 178
8. Disis ML, Calenorff E, Mc Lauglhin G, Murphy AE, Chen W, Groner B, Jeschke M, Lydon N, McGlynn E, Livingstone RB, Moe R, Cheever MA (1994) Existent T-cell and antibody immunity to HER-2/neu protein in patients with breast cancer. Cancer Res 16: 54
9. Disis ML, Gralow JR, Bernhard H, Hand SL, Rubin WD, Cheever MA (1996) Peptide-based, but not whole protein, vaccines elicit immunity to HER-2/neu, an oncogenic self-protein. J Immunol 156: 3151
10. Donnelly JJ, Ulmer JB, Liu MA (1994) Immunization with polynucleotides. A novel approach to vaccination. Immunologist 2/1: 20
11. Drebin JA, Stern DF, Link VC, Weinberg RA, Greene MI (1984) Monoclonal antibodies identify a cell-surface antigen associated with an activated cellular oncogene. Nature 312: 545
12. Drebin JA, Link VC, Stern DF, Weiberg RA, Greene MI (1985) Downregulation of an oncogene protein product and reversion of the transformed phenotype by monoclonal antibodies. Cell 41: 695
13. Drebin JA, Link VC, Weiberg RA, Greene MI (1986) Inhibition of tumor growth by a monoclonal antibody with an oncogene encoded tumor antigen. Proc Natl Acad Sci USA 83: 9129
14. Elson JC, Barker RN, Thompson SJ, Williams NA (1995) Immunologically ignorant autoreactive T cells, epitope spreading and repertoire limitation. Immunol Today 16: 71
15. Guy CT, Webster MA, Schaller M, Parson TJ, Cardiff RD, Muller WJ (1992) Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease. Proc Natl Acad Sci USA 89: 10578
16. Hancock MC, Langton BC, Chan T, Toy P, Monahan JJ, Mischak RP, Shawver LK (1991) A monoclonal antibody against the c-erbB2 protein enhances the cytotoxicity of cis-diammine dichloroplatinum against human breast and ovarian tumor cell lines. Cancer Res 51: 4575
17. Harlow E, Lane D (1988) Antibodies, a laboratory manual. Harlow E, Lane D, Cold Spring Harbor Laboratory, p 479
18. Hurwitz E, Stankovski I, Sela M, Yarden Y (1995) Suppression and promotion of tumor growth by monoclonal antibodies to ErbB-2 differentially correlate with cellular uptake. Proc Natl Acad Sci USA 92: 3353
19. Hynes NE, Stern DF (1994) The biology of erbB2/neu/HER-2 and its role in cancer. Biochim Biophys Acta 1198: 165
20. Jevnikar AM, Grusby MJ, Glimcher LH (1994) Prevention of nephritis in major histocompatibility complex class II deficient MRL-lpr mice. J Exp Med 179: 1137
21. neu receptor. Nat Med 1: 644
22. Knezevic V, Spaventi R, Poljak L, Slade N, Svajger A, Pavelic K (1994) p185 neu is expressed in yolk sac during rat postimplantation development. J Anat 181: 1985
23. Kokay Y, Cohen JA, Debrin JA, Greene MI (1987) Stage and tissue-specific expression of the neu oncogene in rat development. Proc Natl Acad Sci USA 84: 8498
24. Lacroix H, Iglehart JD, Skinner MA, Kraus MH (1989) Overexpression of erbB-2 or EGF receptor proteins present in early stage mammary carcinoma is detected simultaneously in matched primary tumors and regional metastases. Oncogene 4: 145
25. Lanzavecchia A (1995) How can cryptic epitopes trigger autoimmunity? J Exp Med 181: 1945
26. Lin RH, Mamula MJ, Hardin JA, Janeway CA (1991) Induction of autoreactive B cells allows priming of autoreactive T cells. J Exp Med 173: 1433
27. Mamula MJ (1995) Lupus autoimmunity: from peptides to particles. Immunol Rev 144: 301
28. Miettinen PJ, Berger JE, Meneses J, Phung Y, Pedersen RA, Werb Z, Derynck R (1995) Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature 376: 337
29. Nanda NK, Sercaz EE (1995) Induction of anti-selfimmunity to cure cancer. Cell 82: 13
30. Park JW, Stagg R, Lewis GD, Carter P, Maneval D, Slamon DJ, Jaffe H, Shepard HM (1992) In: Dickson RB, Lippmann ME (eds) Genes, oncogenes and hormones: advances in cellular and molecular biology of breast cancer. Kluver, Boston, p 193
31. Pupa SM, Menard S, Andreola S, et al. (1993) Antibody response against the c-erbB2 oncoprotein in breast carcinoma patients. Cancer Res 53: 5864
32. Sato Y, Roman M, Tighe H, Lee D, Corr M, Nguyen M-D, Silverman, GJ, Lotz M, Carson DA, Raz E (1996) Immunostimolatory DNA sequences necessary for effective intradermal gene immunization. Science 273: 352
33. Slamon DJ, Godolphin W, Jones LA, Holt A, Wong SG, Keith DE, Levin WJ, Stuart SG, Udove J, Ullrich A, Press MF (1989) Studies of the HER-2/neu protooncogene in human breast and ovary cancer. Science 244: 707
34. Talbott RL, Spranger EE, Lovelance KM, et al (1989) Nucleotide sequence and genomic organisation of feline immunodeficiency virus. Proc Natl Acad Sci, USA 86: 5743
35. Venanzi FM, Petrelli C, Concetti A, Amici A (1995) neu/HER-2 cDNA vaccination and pregnancy loss. DNA vaccines: a new era in vaccinology. Ann Acad Sci [New York]. Liu MA, Hilleman MR, Kurt R (eds), vol. 772, p 274
36. Weigle WO (1962) Termination of acquired immunological tolerance to protein antigens following immunization with altered protein antigens. J Exp Med 116: 913
37. Whalen RG, Leclerc C, Deriaud E, Schirmbeck R, Reimann J, Davis H (1995) DNA-mediated immunization to the hepatitis B surface antigen: activation and entrainment of the immune response. DNA vaccines: a new era in vaccinology. Ann Acad Sci [New York]. Liu MA, Hilleman MR, Kurt R (eds), vol. 772: p 64
38. Xiang ZQ, Spitalnik S, Tram M, Wunner WH, Cheng J, Ertl HC (1994) Virology 199: 132