Effects of protein kinase A activation on the responses of primate spinothalamic tract neurons to mechanical stimuli

Journal of Neurophysiology

Volumn 88, Issue 1, 2002, Pages 214-221

  Lin, Qing ^a   Wu, Jing ^a   Willis, William D ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 BROMO CYCLIC GMP; ADENYLATE CYCLASE ACTIVATOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; CYCLIC GMP DEPENDENT PROTEIN KINASE; ENZYME ACTIVATOR; FORSKOLIN; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HYPERALGESIA; MALE; MECHANICAL STIMULATION; MICRODIALYSIS; MONKEY; NOCICEPTION; NOCICEPTIVE STIMULATION; NONHUMAN; PRIMATE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SPINOTHALAMIC TRACT;

EID: 0036310518     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.2002.88.1.214     Document Type: Article

References (60)

1. Cyclic AMP synaptic activity-dependent phosphorylation of AMPA-preferring glutamate receptors
2. A mnemonical or negative-cooperativity model for the activation of adenylate cyclase by a common G-protein-coupled calcitonin-gene-related neuropeptide (CGRP)/amylin receptor
3. Cyclic adenosine 3′5′-monophosphate potentiates excitatory amino acid and synaptic responses of rat spinal dorsal horn neurons
4. Enhancement of the N-methyl-D-aspartate response in spinal dorsal horn neurons by cAMP-dependent protein kinase
5. Role of voltage-dependent calcium channel subtypes in experimental tactile allodynia
6. Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells
7. Classification of primate spinothalamic and somatosensory thalamic neurons based on cluster analysis
8. Contribution of protein kinase C to central sensitization and persistent pain following tissue injury
9. Intracellular messengers contributing to persistent nociception and hyperalgesia induced by L-glutamate and substance P in the rat formalin pain model
10. Evidence for a role of the NMDA receptor in the frequency-dependent potentiation of deep rat dorsal horn nociceptive neurones following C-fiber stimulation
11. The glutamate receptor ion channels
12. The role of NMDA and non-NMDA excitatory amino acid receptors in the excitation of primate spinothalamic tract neurons by mechanical, chemical, thermal, and electrical stimuli
13. Neurokinin 1 and 2 antagonists attenuate the responses and NK1 antagonists prevent the sensitization of primate spinothalamic tract neurons after intradermal capsaicin
14. Combined application of excitatory amino acids and substance P produces long-lasting changes in responses of primate spinothalamic tract neurons
15. Enhancement of spinothalamic neuron responses to chemical and mechanical stimuli following combined microiontophoretic application of N-methyl-D-aspartic acid and substance P
16. Enhanced responses of spinothalamic tract neurons to excitatory amino acids accompany capsaicin-induced sensitization in the monkey
17. Effects of cAMP simulate a late stage of LTP in hipocampal CA1 neurons
18. Carrageenan-induced inflammation alters the content of i-cGMP and i-cAMP in the dorsal horn of the spinal cord
19. Role of metabotropic glutamate receptors in the depression of GABA-mediated depolarization of frog primary afferent terminals
20. Phosphorylation of presynaptic and postsynaptic calcium channels by cAMP-dependent protein kinase in hippocampal neurons
21. Prostaglandins facilitate peptide release from rat sensory neurons by activating the adenosine 3′,5′-cyclic monophosphate transduction cascade
22. A genetic test of the effect of mutations in PKA on mossy fiber LTP and its relation to spatial and contextual learning
23. Regulation of the second-messenger systems in the rat spinal cord during prolonged peripheral inflammation
24. Stimulation of adenylate cyclase by water-soluble analogues of forskolin
25. Cyclic AMP-dependent protein kinase and protein kinase phosphorylate N-methyl-D-aspartate receptors at different sites
26. Nitric oxide mediates the central sensitization of primate spinothalamic tract neurons
27. Possible role of protein kinase C in the sensitization of primate spinothalamic tract neurons
28. Inhibition of primate spinothalamic tract neurons by spinal glycine and GABA is reduced during central sensitization
29. Involvement of cGMP in nociceptive processing by and sensitization of spinothalamic neurons in primates
30. Inhibition of primate spinothalamic tract neurons by spinal glycine and GABA is modulated by guanosine 3′,5′-cyclic monophosphate
31. Nitric oxide-mediated spinal disinhibition contributes to the sensitization of primate spinothalamic tract neurons
32. The effects of protein kinase A activation on the responses of primate spinothalamic neurons to mechanical and thermal stimuli
33. NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurons
34. Voltage-sensititive calcium channels in spinal nociceptive processing: Blockade of N- and P-type channels inhibits formalin-induced nociception
35. The role of nitric oxide in the development and maintenance of the hyperalgesia produced by intraplantar injection of carrageenan in the rat
36. Nitric oxide (NO) and nociceptive processing in the spinal cord
37. Role of metabotropic glutamate receptor subtype mGluR1 in brief nociception and central sensitization of primate STT cells
38. Group III metabotropic glutamate receptors differentially modulate brief and prolonged nociception in primate STT cells
39. N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists block the hyperexcitability of dorsal horn neurons during development of acute arthritis in rat's knee joint
40. Involvement of substance P and neurokinin-1 receptors in the hyperexcitability of dorsal horn neurons during development of acute arthritis in rat's knee joint
41. Differential effects of opioid receptors agonists on nociception and cAMP level in the spinal cord of monoarthritic rats
42. Calcitonin gene-related peptide selectively increases cAMP levels in the guinea pig ureter
43. Coupling gene expression to cAMP signalling: Role of CREB and CREM
44. Effects of intrathecal antibodies to substance P, calcitonin gene-related peptide and galanin on repeated cold stress-induced hyperalgesia: Comparison with carrageenan-induced hyperalgesia
45. Metabotropic glutamate receptor modulation of cAMP accumulation in the neonatal rat hippocampus
46. Inhibition of cyclic AMP formation by a selective metabotropic glutamate receptor agonist
47. Voltage-dependent potentiation of neuronal L-type calcium channels due to state-dependent phosphorylation
48. Activation of the cAMP transduction cascade contributes to the mechanical hyperalgesia and allodynia induced by intradermal injection of capsaicin
49. Differential roles of neurokinin 1 and neurokinin 2 receptors in the development and maintenance of heat hyperalgesia induced by acute inflammation
50. Inhibitors of G proteins and protein kinases reduce the sensitization to mechanical stimulation and the desensitization to heat of spinothalamic tract neurons induced by intradermal injection of capsaicin in the primate
51. The effects of G protein and protein kinase inhibitors on the behavioral responses of rats to intradermal injection of capsaicin
52. Joint inflammation and hyperalgesia are reduced by spinal bicuculline
53. Increase in substance P and CGRP but not somatostatin content of innervating dorsal root ganglia in adjuvant monoarthritis in the rat
54. Microdialysis recovery of serotonin released in spinal cord dorsal horn
55. 2+ permeable AMPA receptor antagonist
56. Effects of calcitonin gene-related peptide on cyclic AMP production and relaxation of longitudinal muscle of guinea pig ileum
57. Characterization of protein kinase A and protein kinase C phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit using phosphorylation site-specific antibodies
58. Location of cells of origin of spinothalamic tract in lumbar enlargement of the monkey
59. Sensory transmitters regulate intracellular calcium in dorsal horn neurons
60. Enhanced phosphorylation of NMDA recepter 1 subunits in spinal cord dorsal horn and spinothalamic tract neurons after intradermal injection of capsaicin in rats