Regio- and stereoselective hydroxylation of taxoids by filamentous fungi

Chirality

Volumn 14, Issue 6, 2002, Pages 495-497

  Hu, Shanghui ^a   Sun, Di An ^a   Tian, Xufang ^a   Fang, Qicheng ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Hydroxylation; Microorganisms; Regio and stereoselectivity; Taxoids

Indexed keywords

OXIDOREDUCTASE; PACLITAXEL; TAXANE DERIVATIVE; TAXOID;

ARTICLE; DRUG HYDROXYLATION; ENZYME MECHANISM; ENZYME SPECIFICITY; FUNGUS; NONHUMAN; PRIORITY JOURNAL; REACTION ANALYSIS; STEREOCHEMISTRY;

ABSIDIA; BIOTRANSFORMATION; BRIDGED COMPOUNDS; FUNGI; HYDROXYLATION; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PACLITAXEL; STEREOISOMERISM; TAXOIDS;

EID: 0036309866     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/chir.10078     Document Type: Article

References (9)

1. Cyclization of geranylgeranyl diphosphate to taxa-4(5),11(12)-diene is the committed step of taxol biosynthesis in pacific yew
2. A cDNA clone for taxadiene synthase, the diterpene cyclase that catalyzes the committed step of taxol biosynthesis
3. Cytochrome P450-catalyzed hydroxylation of taxa-4(5),11(12)-diene to taxa-4(20),11(12)-dien-5 alpha-ol: The first oxygenation step in taxol biosynthesis
4. Microbial transformation of taxoids: Selective deacetylation and hydroxylation of 2α,5α10β, 14β-tetra-acetoxy-4(20),11-taxadiene by the fungus Cunnighamella echinulata
5. Biotransformation of some taxoids with oxygen substituent at C-14 by Cunninghamella echinulata
6. Selective microbial hydroxylation and biological rearrangement of taxoids
7. Microbial transformation of taxoids and synthesis of taxoids with an oxetane ring
8. The phytochemistry of the yew tree