The neurobiology of central sensitization

Journal of Musculoskeletal Pain

Volumn 10, Issue 1-2, 2002, Pages 23-33

  Salter, Michael W ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Glutamate receptors; Pain; Spinal dorsal horn; Synaptic plasticity; Tyrosine kinases

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEKAINATE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; GLUTAMATE RECEPTOR; KAINIC ACID DERIVATIVE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

CALCIUM TRANSPORT; CENTRAL NERVOUS SYSTEM; CONFERENCE PAPER; HUMAN; HYPERALGESIA; LONG TERM POTENTIATION; NERVE CELL PLASTICITY; PAIN THRESHOLD; PATHOGENESIS; SENSITIZATION; SIGNAL TRANSDUCTION; SPINAL CORD DORSAL HORN; SYNAPTIC TRANSMISSION;

EID: 0036308714     PISSN: 10582452     EISSN: None     Source Type: Journal    
DOI: 10.1300/J094v10n01_03     Document Type: Conference Paper

References (15)

1. The glutamate receptor ion channels
2. Substance P-mediated slow excitatory postsynaptic potential elicited in dorsal horn neurons in vivo by noxious stimulation
3. Rate of rise of the cumulative depolarization evoked by repetitive stimulation of small-caliber afferents is a predictor of action potential windup in rat spinal neurons in vitro
4. Neuronal plasticity: Increasing the gain in pain
5. Evidence for a central component of post-injury pain hypersensitivity
6. Peripheral and central mechanisms of cutaneous hyperalgesia
7. Long-term potentiation and long-term depression of primary afferent neurotransmission in the rat spinal cord
8. Postsynaptic protein phosphorylation and LTP
9. NMDA receptor regulation by Src kinase signalling in excitatory synaptic transmission and plasticity
10. Silent glutamatergic synapses and long-term facilitation in spinal dorsal horn neurons
11. CAKbeta/Pyk2 kinase is a signaling link for induction of long-term potentiation in CA1 hippocampus
12. Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity
13. 2+-permeable AMPA receptors
14. Brain-derived neurotrophic factor is an endogenous modulator of nociceptive responses in the spinal cord
15. Role of AMPA receptor endocytosis in synaptic plasticity