Multilayers of cells growing on a permeable support. An in vitro tumour model

Acta Oncologica

Volumn 36, Issue 1, 1997, Pages 13-16

  Minchinton, Andrew I ^a   Wendt, Karen R ^a   Clow, Kathy A ^a   Fryer, Karen H ^a  

^a BRITISH COLUMBIA CANCER RESEARCH CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TUMOR MODEL; UTERINE CERVIX CARCINOMA;

EID: 0030904324     PISSN: 0284186X     EISSN: None     Source Type: Journal    
DOI: 10.3109/02841869709100724     Document Type: Article

References (14)

1. Leighton J. The growth patterns of some transplantable animal tumours in 'Sponge Matrix Tissue Culture'. J Natl Cancer Inst 1954; 15: 275-93.
2. Yang J, Richards J, Bowman P, et al. Sustained growth and three-dimensional organization of primary mammary tumor epithelial cells embedded in collagen gels. Proceedings of the National Academy of Sciences of the United States of America, 1979; 76: 3401-5.
3. Hlatky L, Ring C, Sachs RK. Comparison of 3H-misonidazole binding between CHO and 9L cells using the sandwich system. Int J Radiat Oncol Biol Phys 1989; 16: 943-7.
4. Sutherland RM. Cell and environment interactions in tumor microregions: the multicell spheroid model. Science 1988; 240: 177-84.
5. Durand RE. Variable radiobiological responses of spheroids. Radiat Res 1980; 81: 85-99.
6. Freyer JP, Sutherland RM. Regulation of growth saturation and development of necrosis in EMT6/Ro multicellular spheroids by the glucose and oxygen supply. Cancer Res 1986; 46: 3504-12.
7. Luk CK, Sutherland RM. Nutrient modification of proliferation and radiation response in EMT6/Ro. Int J Radiat Oncol Biol Phys. 1987; 13: 885-95.
8. Durand RE. Slow penetration of anthracyclines into spheroids and tumors: a therapeutic advantage? Cancer Chemother Pharmacol 1990; 26: 198-204.
9. Kerr DJ, Wheldon TE, Hydns S, Kaye SB. Cytotoxic drug penetration studies in multicellular tumour spheroids. Xenobiotica 1988; 18: 641-8.
10. Nederman T, Carlsson J, Malmqvist M. Penetration of substances into tumor tissue A methodological study on cellular spheroids. In vitro 1981; 17: 290-8.
11. West GW, Weichselbaum R, Little JB. Limited penetration of methotrexate into human osteosarcoma spheroids as a proposed model for solid tumor resistance to adjuvant chemotherapy. Cancer Res 1980; 40: 3665-8.
12. Wibe E. Resistance to vincristine of human cells grown as multicellular spheroids. Br J Cancer 1980; 42: 937-41.
13. Minchinton AI, Durand RE, Chaplin DJ. Intermittent blood flow in the KHT sarcoma flow cytometry studies using Hoechst 33342. Br J Cancer 1990; 62: 195-200.
14. Olive PL, Chaplin DJ, Durand RE. Pharmacokinetics, binding and distribution of Hoechst 33342 in spheroids and murine tumours. Br J Cancer 1985; 52: 739-46.