SREBP-2 and NF-Y are involved in the transcriptional regulation of squalene epoxidase

Biochemical and Biophysical Research Communications

Volumn 295, Issue 1, 2002, Pages 74-80

  Nagai, Masaaki ^a   Sakakibara, Jun ^a   Nakamura, Yuichi ^a   Gejyo, Fumitake ^a   Ono, Teruo ^a  

^a NIIGATA UNIVERSITY   (Japan)

Author keywords

Cholesterol; NF Y; Squalene epoxidase; SRE; SREBP 2; Transcriptional regulation

Indexed keywords

NUCLEAR FACTOR; NUCLEAR FACTOR Y; SQUALENE MONOOXYGENASE; STEROL REGULATORY ELEMENT BINDING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CONTROLLED STUDY; DNA FLANKING REGION; GENE CONTROL; HUMAN; HUMAN CELL; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

5' FLANKING REGION; ANIMALS; BASE SEQUENCE; CCAAT-BINDING FACTOR; CHOLESTEROL; DNA-BINDING PROTEINS; EXONS; HELA CELLS; HUMANS; INTRONS; MOLECULAR SEQUENCE DATA; OXYGENASES; PROMOTER REGIONS (GENETICS); RATS; RESPONSE ELEMENTS; SEQUENCE ALIGNMENT; SQUALENE MONOOXYGENASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS;

EID: 0036307360     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)00623-X     Document Type: Article

References (31)

1. Ras c-terminal processing enzymes - New drug targets?
2. Geranylgeranylated proteins
3. Regulation of squalene epoxidase in HepG2 cells
4. Regulation of squalene epoxidase activity in rat liver
5. The transcriptional program in the response of human fibroblasts to serum
6. Molecular cloning and expression of rat squalene epoxidase
7. Nucleotide sequence of a cDNA for mouse squalene epoxidase
8. Localization of the squalene epoxidase gene (SQLE) to human chromosome region 8q24.1
9. Transcriptional regulation of squalene epoxidase by sterols and inhibitors in hela cells
10. Regulation of the mevalonate pathway
11. Molecular cloning and functional analysis of the promoter of the human squalene synthase gene
12. Sterol regulatory element binding protein binds to a cis element in the promoter of the farnesyl diphosphate synthase gene
13. Regulation of fatty acid synthase expression by cholesterol in human cultured cells
14. Sterol regulation of acetyl coenzyme a carboxylase: A mechanism for coordinate control of cellular lipid
15. Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment
16. NF-Y has a novel role in sterol-dependent transcription of two cholesterogenic genes
17. Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Sp1
18. Receptor-mediated endocytosis of low-density lipoprotein in cultured cells
19. Sterol regulatory element-binding proteins induce an entire pathway of cholesterol synthesis
20. Sterol regulation of 3-hydroxy-3-methylglutaryl-coenzyme a synthase gene through a direct interaction between sterol regulatory element binding protein and the trimeric CCAAT-binding factor/nuclear factor Y
21. Identification of nucleotides responsible for enhancer activity of sterol regulatory element in low density lipoprotein receptor gene
22. Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y- and Sp-1-binding sites
23. Cholesterol biosynthesis from lanosterol. A concerted role for sp1 and NF-Y-binding sites for sterol-mediated regulation of rat 7-dehydrocholesterol reductase gene expression
24. YY1 is a negative regulator of transcription of three sterol regulatory element-binding protein-responsive genes
25. Repression of the steroidogenic acute regulatory gene by the multifunctional transcription factor Yin Yang 1
26. A novel sequence element is involved in the transcriptional regulation of expression of the ERG1 (squalene epoxidase) gene in Saccharomyces cerevisiae
27. Purification and characterization of recombinant squalene epoxidase
28. An oxysterol signalling pathway mediated by the nuclear receptor LXR α
29. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway
30. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR α
31. An oxysterol-derived positive signal for 3-hydroxy-3-methylglutaryl-CoA reductase degradation in yeast