Anti-V antigen antibody protects macrophages from Yersinia pestis-induced cell death and promotes phagocytosis

Microbial Pathogenesis

Volumn 32, Issue 5, 2002, Pages 227-237

  Weeks, S ^a   Hill, J ^b   Friedlander, A ^a   Welkos, S ^a  

^a UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^b DEFENCE SCIENCE AND TECHNOLOGY LABORATORY   (United Kingdom)

Author keywords

Apoptosis; Phagocytosis; V antigen; Yersinia pestis

Indexed keywords

BACTERIAL ANTIGEN; BACTERIUM ANTIBODY; IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY; POLYCLONAL ANTIBODY;

ANIMAL CELL; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; APOPTOSIS; ARTICLE; BACTERIAL INFECTION; BACTERIAL VIRULENCE; BACTERIUM CULTURE; CELL PROTECTION; CONTROLLED STUDY; CROSS REACTION; CYTOSOL; CYTOTOXICITY; HOST CELL; HOST PATHOGEN INTERACTION; MACROPHAGE; NONHUMAN; PHAGOCYTOSIS; PLASMID; PRIORITY JOURNAL; PROTEIN TRANSPORT; RABBIT; YERSINIA ENTEROCOLITICA; YERSINIA PESTIS; YERSINIA PSEUDOTUBERCULOSIS;

ANIMALIA; BACTERIA (MICROORGANISMS); MURINAE; NEGIBACTERIA; ORYCTOLAGUS CUNICULUS; YERSINIA; YERSINIA ENTEROCOLITICA; YERSINIA PESTIS; YERSINIA PSEUDOTUBERCULOSIS;

EID: 0036303937     PISSN: 08824010     EISSN: None     Source Type: Journal    
DOI: 10.1006/mpat.2002.0498     Document Type: Article

References (57)

1. Role of a plasmid in the pathogenicity of Yersinia species
2. 2+-response plasmid pCD1 of Yersinia pestis KIM5
3. Genome sequence of Yersinia pestis, the causative agent of plague
4. Complete DNA sequence of Yersinia enterocolitica serotype 0:8 low-calcium-response plasmid reveals a new virulence plasmid-associated replicon
5. The 70-kilobase virulence plasmid of Yersinia
6. Pathology of experimental pneumonic plague produced by F1-positive and F1-negative Yersinia pestis in African green monkeys
7. The Yersinia deadly kiss
8. Target cell contact triggers expression and polarized transfer of Yersinia YopE cytotoxin into mammalian cells
9. Translocation of the Yersinia YopE and YopH virulence proteins into target cells is mediated by YopB and YopD
10. The cytotoxic protein YopE of Yersinia obstructs the primary host defence
11. YopT, a new Yersinia Yop effector protein, affects the cytoskeleton of host cells
12. Yersinia enterocolitica induces apoptosis in macrophages by a process requiring functional type III secretion and translocation mechanisms and involving YopP, presumably acting as an effector protein
13. Yersinia pseudotuberculosis inhibits Fc receptor-mediated phagocytosis in J774 cells
14. YopH of Yersinia pseudotuberculosis interrupts early phosphotyrosine signalling associated with phagocytosis
15. The PTPase YopH inhibits uptake of Yersinia, tyrosine phosphorylation of p130Cas and FAK, and the associated accumulation of these proteins in peripheral focal adhesions
16. YopH dephosphorylates Cas and Fyn-binding protein in macrophages
17. A secreted protein kinase of Yersinia pseudotuberculosis is an indispensable virulence determinant
18. Targeting of the Yersinia pestis YopM protein into HeLa cells and intracellular trafficking to the nucleus
19. Inhibition of phagocytosis in Yersinia pseudotuberculosis: A virulence plasmid-encoded ability involving the Yop2b protein
20. Role of YopP in suppression of tumor necrosis factor alpha release by macrophages during Yersinia infection
21. YopJ of Yersinia pseudotuberculosis is required for the inhibition of macrophage TNF-alpha production and downregulation of the MAP kinases p38 and JNK
22. Inhibition of the Fc receptor-mediated oxidative burst in macrophages by the Yersinia pseudotuberculosis tyrosine phosphatase
23. Essential role of YopD in inhibition of the respiratory burst of macrophages by Yersinia enterocolitica
24. Interaction of Yersinia enterocolitica with macrophages leads to macrophage cell death through apoptosis
25. Yersinia signals macrophages to undergo apoptosis and YopJ is necessary for this cell death
26. Yersinia induce apoptosis in vivo aids in the establishment of a systemic infection of mice
27. Yersinia outer membrane protein P of Yersinia enterocolitica simultaneously blocks the nuclear factor-kappa B pathway and exploits lipopolysaccharide signaling to trigger apoptosis in macrophages
28. Disruption of signaling by Yersinia effector YopJ, a ubiquitin-like protein protease
29. Biosynthesis and purification of V and W antigen in Pasteurella pestis
30. Recombinant V antigen protects mice against pneumonic and bubonic plague caused by F1-capsule-positive and -negative strains of Yersinia pestis
31. Roles of V antigen in promoting virulence and immunity in yersiniae
32. Regions of Yersinia pestis V antigen that contribute to protection against plague identified by passive and active immunization
33. Passive immunity to infection with Yersinia spp. mediated by anti-recombinant V antigen is dependent on polymorphism of V antigen
34. Passive immunity to Yersiniae mediated by anti-recombinant V antigen and protein A-V antigen fusion peptide
35. Analysis of the Yersinia enterocolitica 0:8 V antigen for cross protectivity
36. Suppression of cytokines in mice by protein A-V antigen fusion peptide and restoration of synthesis by active immunization
37. V antigen of Yersinia pestis inhibits neutrophil chemotaxis
38. The V-antigen of Yersinia is surface exposed before target cell contact and involved in virulence protein translocation
39. Virulence role of V antigen of Yersinia pestis at the bacterial surface
40. The V antigen of Yersinia pestis regulates Yop vectorial targeting as well as Yop secretion through effects on YopB and LcrG
41. The Yersinia Yop virulon: LcrV is required for extrusion of the translocators YopB and YopD
42. Anti-recombinant V antigen serum promotes uptake of Yersinia enterocolitica serotype 08 by macrophages
43. LcrV is a channel size-determining component of the Yop effector translocon of Yersinia
44. Active and passive immunization with the Pseudomonas V antigen protects against type III intoxication and lung injury
45. LcrG-LcrV interaction is required for control of Yops secretion in Yersinia pestis
46. Roles of LcrG and LcrV during type III targeting of Yops by Yersinia enterocolitica
47. LcrV, a substrate for Yersinia enterocolitica type III secretion, is required for toxin targeting into the cytosol of HeLa cells
48. LcrV of Yersinia pestis enters infected eukaryotic cells by a virulence plasmid-independent mechanism
49. The basis of virulence in Pasteurella pestis: An antigen determining virulence
50. The Yersinia tyrosine phosphatase YopH targets a novel adhesion-regulated signaling complex in macrophages
51. Modulation of Rho GTPases and the actin cytoskeleton by Yersinia outer proteins (Yops)
52. Caspases: Enemies within
53. Deciphering the apoptotic pathway: All roads lead to death
54. Anti-recombinant V antigen serum promotes uptake of Yersinia enterocolitica serotype 08 by macrophages
55. Fraction 1 capsular antigen (F1) purification from Yersinia pestis CO92 and from an Escherichia coli recombinant strain and efficacy against lethal plague challenge
56. Construction of defined F1 negative mutants of virulent Yersinia pestis
57. Protection against experimental bubonic and pneumonic plague by a recombinant capsular F1-V antigen fusion protein vaccine