Physiological concentrations of (-)-epigallocatechin-3-O-gallate (EGCg) prevent chromosomal damage induced by reactive oxygen species in WIL2-NS cells

Journal of Nutrition

Volumn 132, Issue 7, 2002, Pages 1836-1839

  Sugisawa, Ayako ^a   Umegaki, Keizo ^a  

^a NATIONAL INSTITUTE OF HEALTH AND NUTRITION   (Japan)

Author keywords

Chromosomal damage; EGCg; Oxdative stress; Reactive oxygen species; WIL2 NS cells

Indexed keywords

EPIGALLOCATECHIN GALLATE; REACTIVE OXYGEN METABOLITE;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL CULTURE; CELL DAMAGE; CELL DIVISION; CHROMOSOME DAMAGE; DIETARY INTAKE; DNA DAMAGE; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL; OXIDATIVE STRESS; TEA;

EID: 0036303378     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/132.7.1836     Document Type: Article

References (19)

1. Oxidants, antioxidants, and the degenerative diseases of aging
2. Fruit, vegetables, and cancer prevention: A review of the epidemiological evidence
3. Structure-anti-oxidant activity relationships of flavonoids and phenolic acids
4. 2+-induced low density lipoprotein oxidation in propagation phase
5. Effects of epigallocatechin gallate and quercetin on oxidative damage to cellular DNA
6. Analytical method of measuring tea catechins in human plasma by solid phase extraction and HPLC with electrochemical detection
7. Blood and urine levels of tea catechins after ingestion of different amounts of green tea by human volunteers
8. Oxidant-induced DNA damage of target cells
9. Cytokinesis-block micronucleus assay in WIL2-NS cells: A sensitive system to detect chromosomal damage induced by reactive oxygen species and activated human neutrophils
10. A simple colorimetric method for the measurement of hydrogen peroxide produced by cells in culture
11. Protective effects of (-)-epigallocatechin gallate and (+)-catechin on paraquat-induced genotoxicity in cultured cells
12. Artifacts in cell culture: Rapid generation of hydrogen peroxide on addition of (-)-epigallocatechin, (-)-epigallocatechin gallate, (+)-catechin, and quercetin to commonly used cell culture media
13. Mechanisms of growth inhibition of human lung cancer cell line, PC-9, by tea polyphenols
14. Effects of catechins on superoxide and hydroxyl radical
15. Antioxidant chemistry of green tea catechins: New oxidation products of (-)-epigallocatechin gallate and (-)-epigallocatechin from their reactions with peroxyl radicals
16. Biological origin of free radicals, and mechanisms of antioxidant protection
17. Intracellular iron, but not copper, plays a critical role in hydrogen peroxide-induced DNA Damage
18. Antioxidant and iron-chelating activities of the flavonoids catechin, quercetin and diosmetin on iron-loaded rat hepatocyte cultures
19. Supplementation of Jurkat T cells with green tea extract decreases oxidative damage due to iron treatment