Accurate computer-based design of a new backbone conformation in the second turn of protein L

Journal of Molecular Biology

Volumn 315, Issue 3, 2002, Pages 471-477

  Kuhlman, Brian ^a   O'Neill, Jason W ^b   Kim, David E ^a   Zhang, Kam Y J ^b   Baker, David ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b USA   (United States)

Author keywords

Computational protein design; Protein folding; Protein L; hairpin design

Indexed keywords

MUTANT PROTEIN; PROTEIN; PROTEIN L; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; COMPUTER AIDED DESIGN; CRYSTAL STRUCTURE; DATA BASE; MONTE CARLO METHOD; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE; WILD TYPE;

EID: 0036300662     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.5229     Document Type: Article

References (24)

1. De novo protein design: Fully automated sequence selection
2. De novo design of the hydrophobic cores of proteins
3. Manipulation of ligand binding affinity by exploitation of conformational coupling
4. Computational design of an integrin I domain stabilized in the open high affinity conformation
5. Coupling backbone flexibility and amino acid sequence selection in protein design
6. Side-chain and backbone flexibility in protein core design
7. High-resolution protein design with backbone freedom
8. Computer based redesign of a protein folding pathway
9. Structures of the B1 domain of protein L from Peptostreptococcus magnus with a tyrosine to tryptophan substitution
10. A breakdown of symmetry in the folding transition state of protein L
11. Single site mutations induce 3D domain swapping in the B1 domain of Protein L from Peptostreptococcus magnus
12. Beta-hairpin families in globular proteins
13. Native protein sequences are close to optimal for their structures
14. A phage display system for studying the sequence determinants of protein folding
15. Kinetics of folding of the IgG binding domain of peptosteptococcal protein L
16. Processing of X-ray diffraction data collected in oscillation mode
17. Rapid automated molecular replacement by evolutionary search
18. A visual protein crystallographic software system for X11/XView
19. PROCHECK: A program to check the stereochemical quality of protein structures
20. Assessment of protein models with three-dimensional profiles
21. Verification of protein structures: Patterns of nonbonded atomic interactions
22. Free R value: A novel statistical quantity for assessing the accuracy of crystal structures
23. Crystallography & NMR system: A new software suite for macromolecular structure determination