Evidence of dual sites of action of dendrimers: SPL-2999 inhibits both virus entry and late stages of herpes simplex virus replication

Antiviral Research

Volumn 55, Issue 2, 2002, Pages 319-329

  Gong, Yunhao ^a   Matthews, Barry ^b   Cheung, Dorothy ^a   Tam, Teresa ^a   Gadawski, Izabelle ^a   Leung, Daniel ^c   Holan, George ^b   Raff, John ^b   Sacks, Stephen ^a,c  

^a Viridae Clinical Sciences Inc   (Canada)

^b Starpharma Holdings Limited   (Australia)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Dendrimer SPL 2999; Herpes simplex virus; Pre clinical evaluation

Indexed keywords

DENDRIMER; SPL 2999; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOLYSIS; CYTOPATHOGENIC EFFECT; DNA SYNTHESIS; DRUG EFFICACY; DRUG MECHANISM; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; SOUTHERN BLOTTING; VERO CELL; VIRUS ADSORPTION; VIRUS CULTURE; VIRUS INFECTIVITY; VIRUS INHIBITION; VIRUS REPLICATION;

ANIMALS; ANTIVIRAL AGENTS; CERCOPITHECUS AETHIOPS; DNA, VIRAL; HERPES SIMPLEX; HERPESVIRUS 1, HUMAN; HERPESVIRUS 2, HUMAN; HUMANS; MACROMOLECULAR SUBSTANCES; MICROBIAL SENSITIVITY TESTS; PLAQUE ASSAY; POLYMERS; VERO CELLS; VIRUS REPLICATION;

ANIMALIA; HUMAN HERPESVIRUS 1; HUMAN HERPESVIRUS 2; SIMPLEXVIRUS;

EID: 0036298609     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-3542(02)00054-2     Document Type: Article

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