Molecular and fluorescent sterol approaches to probing lysosomal membrane lipid dynamics

Chemistry and Physics of Lipids

Volumn 116, Issue 1-2, 2002, Pages 19-38

  Gallegos, Adalberto M ^a   Atshaves, Barbara P ^a   Storey, Stephen ^a   Schoer, Jonathan ^a   Kier, Ann B ^b   Schroeder, Friedhelm ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Cholesterol; Lysosome; Membrane; Microdomain; Sterol carrier protein 2

Indexed keywords

ALBUMIN; CHOLESTEROL; CHOLESTEROL ESTERASE; FATTY ACID DERIVATIVE; HIGH DENSITY LIPOPROTEIN; LIPID TRANSFER PROTEIN; LOW DENSITY LIPOPROTEIN; MEMBRANE LIPID; PHOSPHATIDIC ACID; SPHINGOMYELIN PHOSPHODIESTERASE; STEROL CARRIER PROTEIN; DIAGNOSTIC AGENT; FLUORESCENT DYE; LIPID; STEROL;

ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; CHOLESTEROL ESTERIFICATION; CONTROLLED STUDY; FLUORESCENCE; GENETIC TRANSFECTION; IN VITRO STUDY; L CELL; LIPID MEMBRANE; LIPID TRANSPORT; LYSOSOME MEMBRANE; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LIPID INTERACTION; ANIMAL; CELL LINE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; INTRACELLULAR MEMBRANE; KINETICS; LIPID METABOLISM; LYSOSOME; METABOLISM; TRANSPORT AT THE CELLULAR LEVEL; ULTRASTRUCTURE;

ANIMALS; BIOLOGICAL TRANSPORT; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCENT DYES; INTRACELLULAR MEMBRANES; KINETICS; LIPID METABOLISM; LIPIDS; LYSOSOMES; MICE; STEROLS; TRANSFECTION;

EID: 0036294467     PISSN: 00093084     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-3084(02)00018-X     Document Type: Article

References (103)

1. The mechanism of action of steroidogenic acute regulatory protein (StAR)
2. Expression and intracellular processing of the 58 kDa sterol carrier protein 2/3-oxoacyl-CoA thiolase in transfected mouse L-cell fibroblasts
3. Sterol carrier protein-2 alters HDL-mediated cholesterol efflux
4. Lipid binding to sterol carrier protein-2 is inhibited by ethanol
5. Sterol carrier protein-2 overexpression enhances sterol cycling and inhibits cholesterol ester synthesis and high density lipoprotein cholesterol secretion
6. Effect of lipid composition on the transfer of sterols mediated by non-specific lipid transfer protein (sterol carrier protein-2)
7. Intracellular cholesterol trafficking: Role of the NPC1 protein
8. Rat liver proteins capable of transferring phosphatidylethanolamine
9. Rapid intracellular transport of LDL-derived cholesterol to the plasma membrane in cultured fibroblasts
10. Transbilayer movement of cholesterol in the human eurythrocyte membrane
11. Sterol domains in phospholipid membranes: Dehydroergosterol polarization measures molecular sterol transfer
12. Acidic phospholipids strikingly potentiate sterol carrier protein 2 mediated intermembrane sterol transfer
13. Niemann-Pick C1 disease gene: Homology to medicators of cholesterol homeostasis
14. Structure and polarity of mouse brain synaptic plasma membrane: Effects of ethanol in vitro and in vivo
15. Cholesterol interactions with recombinant human sterol carrier protein-2
16. Selective uptake of lipoprotein free cholesterol and its intracellular transport-role of caveolin
17. Intracellular cholesterol transport
18. Fluorescence of delta 5,7,9(11),22-ergostatetraen-3 beta-ol in micelles, sterol carrier protein complexes, and plasma membranes
19. Delta 5,7,9(11)-cholestatrien-3 beta-ol: A fluorescent cholesterol analogue
20. Structure and dynamic properties of dehydroergosterol, delta 5,7,9(11),22-ergostatetraen-3 beta-ol
21. Sterol carrier protein-2, a new fatty acyl coenzyme A-binding protein
22. Spontaneous and protein-mediated sterol transfer between intracellular membranes
23. Fibroblast membrane sterol kinetic domains: Modulation by sterol carrier protein 2 and liver fatty acid binding protein
24. Lith genes induce overexpression of sterol carrier protein 2 during cholesterol gallstone formation
25. Sterol carrier protein-2 participates in hypersecretion of biliary cholesterol during cholesterol gallstone formation in genetically gallstone susceptible mice
26. Phospholipid binding and transfer by non-specific lipid transfer protein (SCP-2): A kinetic model
27. The low-affinity lipid binding site of the non-specific lipid transfer protein. Implications for its mode of action
28. Sterol carrier protein-2 expression alters plasma membrane lipid distribution and cholesterol dynamics
29. NMR structure of the sterol carrier protein-2: Implications for the biological role
30. Lipoprotein receptors and the control of plasma LDL cholesterol levels
31. Studies with sterol carrier protein-2 (SCP-2) gene knockout mice identify liver fatty acid binding protein (FABP1) as intracellular cholesterol transporter contributing to biliary cholesterol hypersecretion and gallstone formation
32. Asymmetric transbilayer distribution of sterol across plasma membranes determined by fluorescence quenching of dehydroergosterol
33. Role of acidic phospholipids in intermembrane sterol transfer
34. Regulation of membrane cholesterol domains by sterol carrier protein-2
35. Interaction of the N-terminus of sterol carrier protein-2 with membranes: Role of membrane curvature
36. The sterol carrier protein-2 amino terminus: A membrane interaction domain
37. Intracellular sterol distribution in transfected mouse L-cell fibroblasts expressing rat liver fatty acid binding protein
38. Steroidogenic acute regulatory protein (StAR) is a sterol transfer protein
39. Aberrant oxidation of the cholesterol side chain in bile acid synthesis of sterol carrier protein-2/sterol carrier protein-x knockout mice
40. Erythrocyte membrane lateral sterol domains: A dehydroergosterol fluorescence polarization study
41. Subcellular localization of sterol carrier protein-2 in rat hepatocytes: Its primary localization to peroxisomes
42. Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport
43. Charting the fate of the "good cholesterol": Identification and characterization of the high density lipoprotein receptor SR-B1
44. Pharmacological inhibition of the intracellular transport of low-density lipoprotein-derived cholesterol in Chinese hamster ovary cells
45. Analysis of somatic cell mutants that express defective intracellular cholesterol transport
46. Does cholesterol bind to the steroidogenic acute regulatory (STAR) protein?
47. Expression of the mature and the pro-form of human sterol carrier protein 2 in Escherichia coli alters bacterial lipids
48. Peroxisomes and sterol carrier protein-2 in luteal cell steroidogenesis: A possible role in cholesterol transport from lipid droplets to mitochondria
49. Leydig cell peroxisomes and sterol carrier protein-2 in luteinizing hormone-deprived rats
50. Luteinizing hormone causes rapid and transient changes in rat Leydig cell peroxisome volume and intraperoxisomal sterol carrier protein-2 content
51. Sterol carrier protein-2 expression in mouse L-cell fibroblasts alters cholesterol uptake
52. The participation of sterol carrier protein-2 (SCP-2) in cholesterol metabolism
53. Relevance of the sterol carrier protein-2 gene for bile acid synthesis and gallstone formation in genetically susceptible mice
54. Sterol carrier protein-2 expression increases fatty acid uptake and cytoplasmic diffusion in L-cell fibroblasts
55. Sterol carrier protein-2 mediated cholesterol esterification in transfected L-cell fibroblasts
56. Sterol carrier protein-2 mediated cholesterol esterification in transfected L-cell fibroblasts
57. Sterol carrier protein-2 expression alters phospholipid content and fatty acid composition in L-cell fibroblasts
58. Effects of chronic ethanol consumption on sterol transfer protein in mouse brain
59. Cholesterol esterase: A cholesterol transfer protein
60. A fluorescence and radiolabel study of sterol exchange between membranes
61. Time-resolved fluorescence investigation of membrane cholesterol heterogeneity and exchange
62. What the Niemann-Pick C gene has taught us about cholesterol transport
63. The Niemann-Pick C1 protein resides in a vesicular compartment linked to retrograde transport of multiple lysosomal cargo
64. Binding of fluorescent-labeled phosphatidylcholine to rat liver non-specific lipid transfer protein
65. Steroidogenic acute regulatory protein binds cholesterol and modulates mitochondrial membrane sterol domain dynamics
66. Modulation on introhepatic cholesterol trafficking: Evidence by in vivo antisense treatment for the involvement of sterol carrier protein-2 in newly synthesized cholesterol transfer into bile
67. Sterol carrier protein-2 is involved in cholesterol transfer from the endoplasmic reticulum to the plasma membrane in human fibroblasts
68. The presence and subcellular distribution of sterol carrier protein-2 in embryonic chick tissue
69. Deficiencies in sex-regulated expression and levels of two hepatic sterol carrier proteins in a murine model of Niemann-Pick type C disease
70. Side-chain structure is critical for the transport of sterols from lysosomes to cytoplasm
71. Sterol carrier and lipid transfer proteins
72. Lysosomal membrane cholesterol dynamics: Role of sterol carrier protein-2 gene products
73. Fluorescent sterols: Probe molecules of membrane structure and function
74. Interaction of fluorescent delta 5,7,9(11),22-ergostatetraen-3b-ol with sterol carrier protein-2
75. Sterol and squalene carrier protein interactions with fluorescent delta 5,7,9(11)-cholestatrien-3 beta-ol
76. Intracellular cholesterol binding proteins, cholesterol transport and membrane domains
77. Pro-sterol carrier protein-2: Role of the N-terminal presequence in structure, function, and peroxisomal targeting
78. Recent advances in membrane microdomains: Rafts, caveolae and intracellular cholesterol trafficking
79. Probing the ligand binding sites of fatty acid and sterol carrier proteins: Effects of ethanol
80. Transmembrane cholesterol distribution
81. Isolation and characterization of subcellular membranes with altered phospholipid composition from cultured fibroblasts
82. Functional analysis of sterol carrier protein-2 (SCP2) in SCP2 knockout mouse
83. Sterol carrier protein X is peroxisomal 3-oxoacyl coenzyme A thiolase with intrinsic sterol carrier and lipid transfer activity
84. Defective peroxisomal catabolism of branched fatty acyl coenzyme A in mice lacking the sterol carrier protein-2/sterol carrier protein-x gene function
85. Scavenger receptors, caveolae, caveolin, and cholesterol trafficking
86. Sterol carrier protein-2 immunolocalization in endoplasmic reticulum and stimulation of phospholipid formation
87. Intramitochondrial cholesterol transfer
88. Intramitochondrial cholesterol transfer in steroidogenic cells
89. The sterol carrier protein-2 fatty acid binding site: An NMR, circular dichroic, and fluorescence spectroscopic determination
90. 13C-NMR investigation of cholesterol and fatty acid binding sites
91. Plasma membrane lipid composition modulates action of anesthetics
92. Charged anesthetics selectively alter plasma membrane order
93. 2) is located in rat liver peroxisomes
94. Evidence for a cholesterol transport pathway from lysosomes to endoplasmic reticulum that is independent of the plasma membrane
95. Evidence for a cholesterol transport pathway from lysosomes to endoplasmic reticulum that is independent of the plasma membrane
96. Sterol carrier and lipid transfer proteins
97. Ultrastructural localization of a peroxisomal protein in rat liver using the specific antibody against the nonspecific lipid transfer protein (sterol carrier protein -2)
98. The occurrence of soluble and membrane-bound non-specific lipid transfer protein (sterol carrier protein 2) in rat tissues
99. Metabolism of phosphatidylglycerol and bis(monoacylglycero)-phosphate in macrophage subcellular fractions
100. Conversion of phosphatidylglycerol to lyso(bis)phosphatidic acid by alveolar macrophages [published erratum appears in FASEB J 1988 Mar 1;2(3):264]
101. Dependence of the polarization of the fluorescence on the concentration
102. Liver fatty acid binding protein enhances sterol transfer by membrane interaction
103. Overexpression of sterol carrier protein-2 in mice leads to increased hepatic cholesterol content and enterohepatic circulation of bile acids