Randomized blinded study of aprotinin infusion for liver crush injuries in the pig model

American Surgeon

Volumn 63, Issue 2, 1997, Pages 113-120

  Thomae, Keith R ^a   Mason, D Laron ^a   Rock Jr , William A ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APROTININ; SERINE PROTEINASE INHIBITOR;

ABDOMINAL BLEEDING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CRUSH TRAUMA; DRUG EFFECT; DRUG SCREENING; LIVER INJURY; NONHUMAN; SHOCK; SWINE;

ABDOMINAL INJURIES; ANIMALS; APROTININ; GASTROINTESTINAL HEMORRHAGE; HEMOSTATICS; INFUSIONS, INTRAVENOUS; LIVER; SERINE PROTEINASE INHIBITORS; SHOCK, HEMORRHAGIC; SWINE; WOUNDS, NONPENETRATING;

EID: 0031016822     PISSN: 00031348     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Royston D, Bidstrup BP, Taylor KM, Sapsford RN. Effect of aprotinin on need for bood transfusions after repeat open heart surgery. Lancet 1987;2:1289-91.
2. Bidstrup BP, Royston D, Taylor KM, Sapsford RN. Reduction in blood loss and blood use after cardiopulmonary bypass with high dose aprotinin (Trasylol®). J Thorac Cardiovasc Surg 1989;97:364-72.
3. Blauhut B, Gross C, Necek S, et al. Effects of high-dose aprotinin on blood loss, platelet function, fibrinolysis, complement, and renal function after cardiopulmonary bypass. J Thorac Cardiovasc Surg 1991;101:958-67.
4. Bidstrup BP, Harrison J, Royston D, et al. Aprotinin therapy in cardiac operations: A report on use in 41 cardiac centers in the United Kingdom. Ann Thorac Surg 1993;55:971-6.
5. Royston D. High-dose aprotinin therapy: A review of the first five years' experience. J Cardiothorac Vasc Anesth 1992;6:76-100.
6. van Oeveren W, Jansen NJG, Bidstrup BP, et al. Effects of aprotinin on hemostatic mechanisms during cardiopulmonary bypass. Ann Thorac Surg 1987;44:640-5.
7. Havel M, Teufelsbauer H, Knobl P, et al. Effect of intraoperative aprotinin administration on postoperative bleeding in patients undergoing cardiopulmonary bypass operation. J Thorac Cardiovasc Surg 1991;101:968-72.
8. van Oeveren W, Harder M, Roozendaal K. Aprotinin protects platelets against the initial effects of cardiopulmonary bypass. J Thorac Cardiovasc Surg 1990;99:788-97.
9. Smet A, Joen M, van Oeveren W, et al. Increased anticoagulation during cardiopulmonary bypass by aprotinin. J Thorac Cardiovasc Surg 1990;100:520-7.
10. Wildevuur CRH, Eijsman L, Roozendaal KJ, et al. Platelet preservation during cardiopulmonary bypass with aprotinin. Eur J Cardiothorac Surg 1989;3:533-8.
11. Dietrich W, Spannagl M, Jochum M, et al. Influence of high-dose aprotinin treatment on blood loss and coagulation patterns in patients undergoing myocardial revascularization. Anesthesiology 1990;73:1119-26.
12. Nagaoka H, Innami R, Murayama F, et al. Effects of aprotinin on prostaglandin metabolism and platelet function in open heart surgery. J Cardiovasc Surg 1991;32:31-7.
13. van Oeveren W, Eijsman L, Roozendaal KJ, Wildevuur CR. On the mechanism of platelet preservation during cardiopulmonary bypass by aprotinin. Lancet 1988;1:644.
14. Marx G, Pokar H, Reuter H, et al. The effects of aprotinin on hemostatic function during cardiac surgery. J Cardiothorac Vasc Anesth 1991;5:467-74.
15. Hunt BJ, Yacoub M. Aprotinin and cardiac surgery (Editorial). Br Med J 1991;303:660-1.
16. Kawasuji M, Ueyama K, Sakakibara N, et al. Effect of low-dose aprotinin on coagulation and fibrinolysis in cardiopulmonary bypass. Ann Thorac Surg 1993;55:1205-9.
17. Thompson JF, Roath OS, Francis JL, et al. Aprotinin in peripheral vascular surgery. Lancet 1990;335:911.
18. Cooper JD. Use of aprotinin in thoracic surgery. Perfusion 1996;11:313-8.
19. Kosters S, Wand H. Uber die Beeinflussung des Blutverlustes nach Prostatoperationen durch praoperative Applikation von Antifibrinolytica. Urologe 1973;12:295-6.
20. Mallett SV, Cox S, Burroughs AK, Rolles K. Aprotinin and reduction of blood loss and transfusion requirements in orthotopic liver transplantation. Lancet 1990;336:886-7.
21. Neuhas P, Bechstein W, Lefebre B, et al. Effect of aprotinin on intraoperative bleeding and fibrinolysis in liver transplantation. Lancet 1989;2(8668):9:24-5.
22. Mallett SV. The intra-operative use of aprotinin (Trasylol®) in orthotopic liver transplantation. Transplant Proc 1991;23:1931-2.
23. Bechstein WO, Riess H, Blumhardt G, et al. Aprotinin in orthotopic liver transplantation. Semin Thromb Hemostasis 1993;19:262-7.
24. Glenn TM, Herlihy BL, Lefer AM. Protective action of a protease inhibitor in hemorrhagic shock. Arch Int Pharmacodyn Ther 1973;203:292-304.
25. McMichan JC, Rosengarten DS, Philipp E. Prophylaxis of post-traumatic pulmonary insufficiency by protease-inhibitor therapy with aprotinin: A clinical study. Circ Shock 1982;9:107-16.
26. Gubler KD, Gentilello LM, Hassantash SA, Maier RV. The impact of hypothermia on dilutional coagulopathy. J Trauma 1994;36:847-51.