Translocation of pleckstrin requires its phosphorylation and newly formed ligands

Biochemical and Biophysical Research Communications

Volumn 293, Issue 1, 2002, Pages 640-646

  Sloan, Denis C ^a   Wang, Ping ^a   Bao, Xiankun ^a   Haslam, Richard J ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

GTP binding proteins; PH domain; Phosphorylation; Platelet; Pleckstrin; Protein kinase C; Translocation

Indexed keywords

ADENOSINE TRIPHOSPHATE; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); LIGAND; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHORUS 32; PLECKSTRIN; PROTEIN KINASE C; SEROTONIN; STREPTOLYSIN O; TRITON X 100;

ARTICLE; CELL MEMBRANE PERMEABILITY; CELL SECRETION; CELL STIMULATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SEROTONIN RELEASE; THROMBOCYTE;

BLOOD PLATELETS; BLOOD PROTEINS; CELL MEMBRANE PERMEABILITY; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; LIGANDS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN TRANSPORT; RECOMBINANT PROTEINS; TETRADECANOYLPHORBOL ACETATE;

EID: 0036290933     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)00260-7     Document Type: Article

References (36)

1. A role of calcium-activated phospholipid-dependent protein kinase in human platelet activation. Comparison of thrombin and collagen actions
2. Purification and characterization of the 47,000-dalton protein phosphorylated during degranulation of human platelets
3. Protein kinase C regulates pleckstrin by phosphorylation of sites adjacent to the N-terminal pleckstrin homology domain
4. Phosphorylation of human pleckstrin on Ser-113 and Ser-117 by protein kinase C
5. Pleckstrin domain homology
6. A putative modular domain present in diverse signaling proteins
7. Pleckstrin's repeat performance: A novel domain in G-protein signaling?
8. Molecular cloning and expression of the major protein kinase C substrate of platelets
9. Regulatory recruitment of signalling molecules to the cell membrane by pleckstrin-homology domains
10. Signal-dependent membrane targeting by pleckstrin homology (PH) domains
11. Binding of G protein βγ-subunits to pleckstrin homology domains
12. Molecular cloning of rat RAC protein kinase α and β and their association with protein kinase C
13. The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C
14. The pleckstrin homology domain of protein kinase D interacts preferentially with the η isoform of protein kinase C
15. Pleckstrin homology domains interact with filamentous actin
16. Pleckstrin homology domains bind to phosphatidyinositol-4,5-bisphosphate
17. Phosphopleckstrin inhibits Gβγ-activable platelet phosphatidylinositol-4,5-bisphosphate 3-kinase
18. βγ
19. Recruitment of pleckstrin and phosphoinositide 3-kinase γ into the cell membranes, and their association with Gβγ after activation of NK cells with chemokines
20. Phosphorylation of platelet pleckstrin activates inositol polyphosphate 5-phosphatase I
21. Pleckstrin inhibits phosphoinositide hydrolysis initiated by G-protein-coupled and growth factor receptors. A role for pleckstrin's PH domains
22. 2-terminal PH domain
23. Pleckstrin induces cytoskeletal reorganization via a Rac-dependent pathway
24. Phosphorylation and subcellular redistribution of pleckstrin in human neutrophils
25. 2+-dependent mechanisms of secretion from streptolysin O-permeabilized platelets: Effects of leakage of cytosolic proteins
26. 2+-independent actions of phorbol ester and GTPγS
27. Identification of a membrane skeleton in platelets
28. Chemical cross-linking of pleckstrin in human platelets: Evidence for oligomerization of the protein and its dissociation by protein kinase C
29. Phosphorylation- and GTP[S]-dependent translocation of pleckstrin to membranes in streptolysin (SLO)-permeabilized platelets
30. Differential interactions of the N- and C-terminal PH domains of pleckstrin with phospholipids
31. 2+-independent secretion and phospholipase D activity in permeabilized human platelets. Inhibition by BAPTA and analogues
32. A G-protein βγ-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosoln
33. βγ subunits and lipid
34. The PH domain and the polybasic c domain of cytohesin-1 cooperate specifically in plasma membrane association and cellular function
35. Targeting of Tiam1 to the plasma membrane requires the cooperative function of the N-terminal pleckstrin homology domain and an adjacent protein interaction domain
36. Synergistic activation of dynamin GTPase by Grb2 and phosphoinositides