Concerted motions in HIV-1 TAR RNA may allow access to bound state conformations: RNA dynamics from NMR residual dipolar couplings

Journal of Molecular Biology

Volumn 315, Issue 2, 2002, Pages 95-102

  Al Hashimi, Hashim M ^a   Gosser, Yuying ^a   Gorin, Andrey ^a   Hu, Weidong ^a   Majumdar, Ananya ^a   Patel, Dinshaw J ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Collective motions; Induced fit interactions; RNA recognition; Tat protein; Tertiary structure capture

Indexed keywords

TRANSACTIVATOR PROTEIN; VIRUS RNA;

ARTICLE; DNA RESPONSIVE ELEMENT; DYNAMICS; HUMAN IMMUNODEFICIENCY VIRUS 1; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0036290269     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.5235     Document Type: Article

References (35)

1. Induced fit in RNA-protein recognition
2. Adaptive recognition in RNA complexes with peptides and protein modules
3. NMR methodology for the study of nucleic acids
4. Current topics in RNA-protein recognition: Control of specificity and biological function through induced fit and conformational capture
5. Direct measurement of distances and angles in biomolecules by NMR in a dilute liquid crystalline medium
6. NMR structures of biomolecules using field oriented media and residual dipolar couplings
7. Regulation of mRNA accumilation by a human immunodeficiency virus transactivator protein
8. Transactivation of human immunodeficiency virus occurs via a bimodal mechanism
9. Activation of HIV transcription by Tat
10. Structural biology of HIV
11. Conformation of the TAR RNA-arginine complex by NMR spectroscopy
12. The structure of the human-immunodeficiency-virus type-1 Tar RNA reveals principles of RNA recognition by Tat protein
13. Structure of HIV-1 TAR RNA in the absence of ligands reveals a novel conformation of the trinucleotide bulge
14. Characterization of the solution conformations of unbound and Tat peptide-bound forms of HIV-1 TAR RNA
15. The bend in RNA created by the transactivation response element bulge of human-immunodeficiency virus is straightened by arginine and by Tat-derived peptide
16. A 1.3 Å resolution crystal structure of the HIV-1 trans-activation response region RNA stem reveals a metal ion-dependent bulge conformation
17. Molecular dynamics studies of the HIV-1 TAR and its complex with argininamide
18. Nuclear magnetic dipole interactions in field-oriented proteins - Information for structure determination in solution
19. Tunable alignment of macromolecules by filamentous phage yields dipolar coupling interactions
20. NMR evidence for slow collective motions in cyanometmyoglobin
21. Structural and dynamic analysis of residual dipolar coupling data for proteins
22. Model-free approach to the dynamic interpretation of residual dipolar couplings in globular proteins
23. Conformational analysis of a fluexible oligosaccharide using residual dipolar couplings
24. Order matrix analysis of residual dipolar couplings using singular value decomposition
25. Field-and phage-induced dipolar couplings in a homo-dimeric DNA quadruplex, relative orientation of G·(C-A) triad and G-tetrad motifs and direct determination of C2 symmetry axis orientation
26. Domain orientation and dynamics in multidomain proteins from residual dipolar couplings
27. Global structure of RNA determined with residual dipolar couplings
28. Predicition of sterically induced alignment in a dilute liquid crystalline phase; aid to protein structure determination by NMR
29. Protein dynamics and conformational transitions in allosteric proteins
30. Active site dynamics in the lead-dependent ribozyme
31. An introduction to hydrogen bond scalar couplings
32. Determining stoichiometry in homomultimeric nucleic acid complexes using magnetic field induced residual dipolar couplings
33. Peptide-triggered conformational switch in HIV-1 RRE RNA complexes
34. Measurement of dipolar contributions to (1)J(CH) splittings from magnetic-field dependence of J modulation in two- dimensional NMR spectra
35. Measurement of J and dipolar couplings from simplified two- dimensional NMR spectra