The behavior of paracetamol in mixtures of amphiprotic and amphiprotic-aprotic solvents. Relationship of solubility curves to specific and nonspecific interactions

Chemical and Pharmaceutical Bulletin

Volumn 44, Issue 5, 1996, Pages 1061-1064

  Romero, Susana ^a   Reillo, Aurora ^a   Escalera, Begoña ^a   Bustamante, Pilar ^a  

^a UNIVERSITY OF ALCALÁ   (Spain)

Author keywords

Chameleonic effect; Paracetamol; Predicting solubility; Solubility parameter; Solvent mixtures; Specific non specific interaction

Indexed keywords

ACETIC ACID ETHYL ESTER; ALCOHOL; BENZOIC ACID; BENZOIC ACID ESTER DERIVATIVE; CAFFEINE; DIOXANE DERIVATIVE; PARACETAMOL; SOLVENT;

AQUEOUS SOLUTION; ARTICLE; BINDING KINETICS; DRUG ALCOHOL INTERACTION; DRUG BINDING; DRUG MIXTURE; DRUG SOLUBILITY; MATHEMATICAL ANALYSIS; PREDICTION;

EID: 0029895688     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.44.1061     Document Type: Article

References (15)

1. Escalera J. B., Bustamante P., Martin A., J. Pharm. Pharmacol., 46, 172 (1994).
2. Bustamante P., Ochoa R., Reillo A., Escalera J.-B., Chem. Pharm. Bull., 42, 1129 (1994).
3. Martin A., Paruta A. N., Adjei A., J. Pharm. Sci., 70, 1115 (1981).
4. Karger B. L., Snyder L. R., Eon C., J. Chromatogr., 125, 71 (1976).
5. Hildebrand J. H., Prausnitz J. M., Scott R. L., "Regular and Related Solutions," Van Nostrand Reinhold, New York, 1970.
6. Chertkoff M. J., Martin A., J. Am. Pharm. Assoc., Sci. Ed., 49, 444 (1960).
7. Subrahmanyam C. V. S., Sreenivasa Reddy M., Ventkata Rao J., Gundu Rao P., Int. J. Pharmaceutics, 78, 17 (1992).
8. Williams N. A., Amidon G. L., Pharm. Res., 5, 193 (1988).
9. Bustamante P., Escalera B., J. Pharm. Pharmacol., 47, 550 (1995).
10. Rubino J. T., Obeng E. K., J. Pharm. Sci., 80, 479 (1991).
11. Drago R. S., "Applications of Electrostatic-Covalent Models in Chemistry," Surfside Sci. Pub., Gainesville, Florida, 1994.
12. Bustamante P., Jiménez-Durán M., Escalera B., Int. J. Pharmaceutics, (1996) in press.
13. Drago R. S., Hirsch M. S., Ferris D. C., Chronister C. W., J. Chem. Soc., Perkin Trans. 2, 1994, 219.
14. Bustamante P., Escalera B., Martin A., Sellés E., J. Pharm. Pharmacol., 45, 253 (1993).
15. Paruta A. N., Irani S. A., J. Pharm. Sci., 55, 1055 (1966).