Antimorphic PV.1 Causes secondary axis by inducing ectopic organizer

Biochemical and Biophysical Research Communications

Volumn 292, Issue 4, 2002, Pages 1081-1086

  Hwang, Yoo Seok ^a   Seo, Jeong Jae ^a   Cha, Sang Wook ^a   Ja Park, Mae ^a   Lee, Hyun Shik ^b   Lee, Sung Young ^b   Kim, Jaebong ^b   Kung, Hsiang fu ^c   Roh, Dong Hyun ^d  

^a Kyungpook National University School of Medicine   (South Korea)

^b Hallym University   (South Korea)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

^d NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Antimorphic PV.1; BMP 4; Dorsoventral axis; Ectopic organizer; Homeobox; Loss of function; PV.1; Secondary axis; Ventralization; Xenopus laevis embryo

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; HOMEODOMAIN PROTEIN; HYBRID PROTEIN; MESSENGER RNA; PROTEIN N PV1 ENR; PROTEIN PV 1; PROTEIN XVENT 1; PROTEIN XVENT 2; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BLASTULA; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; EMBRYO; EMBRYO AXIS; GENE CONSTRUCT; GENE FUNCTION; HOMEOBOX; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; XENOPUS LAEVIS;

ANIMALIA; XENOPUS; XENOPUS LAEVIS;

EID: 0036280526     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2002.6740     Document Type: Article

References (30)

1. Bone morphogenetic protein-4 (BMP-4) acts during gastrula stages to cause ventralization of Xenopus embryos
2. A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo
3. Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes
4. The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4
5. Direct binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in early Xenopus embryo
6. A nodal-related gene defines a physical and functional domain within the Spemann organizer
7. Direct neural induction and selective inhibition of mesoderm and epidermis inducers by Xnr3
8. Head induction by simultaneous repression of Bmp and Wnt signaling in Xenopus
9. The head inducer Cerberus is a multifunctional antagonist of Nodal. BMP and Wnt signals
10. Antagonizing the Spemann organizer: Role of the homeobox gene Xvent-1
11. The Xvent-2 homeobox gene is part of the BMP-4 signaling pathway controlling dorsoventral patterning of Xenopus mesoderm
12. Xmsx-1 modifies mesodermal tissue pattern along dorsoventral axis in Xenopus laevis embryo
13. BMP-4-responsive regulation of dorsal-ventral patterning by the homeobox protein Mix.1
14. A novel homeobox gene PV.1 mediates induction of ventral mesoderm in Xenopus embryos
15. Xenopus gene, Xbr-1, defines a novel class of homeobox genes and is expressed in the dorsal ciliary margin of the eye
16. Regulation of dorsal-ventral patterning: The ventralizing effects of the novel Xenopus homeobox gene Vox
17. Xom: A Xenopus homeobox gene that mediates the early effects of BMP-4
18. Differential regulation of neurogenesis by the two Xenopus GATA-1 genes
19. The role of BMP-4 and GATA-2 in the induction and differentiation of hematopoietic mesoderm in Xenopus laevis
20. Requirement for Xvent-1 and Xvent-2 gene function in dorsoventral patterning of Xenopus mesoderm
21. Regulation of dorsal gene expression in Xenopus by the ventralizing homeodomain gene Vox
22. The Xvex-1 antimorph reveals the temporal competence for organizer formation and an early role for ventral homeobox genes
23. Requirement of Xmsx-1 in the BMP-triggered ventralization of Xenopus embryos
24. Suppression of GATA factor activity causes axis duplication in Xenopus
25. Transcriptional regulation of Xvent homeobox genes
26. The homeobox gene PV.1 mediates specification of the prospective neural ectoderm in Xenopus embryos
27. The entire mesodermal mantle behaves as Spemann’s organizer in dorsoanterior enhanced Xenopus laevis embryos
28. Inhibition of Xbra transcription activation causes defects in mesodermal patterning and reveals autoregulation of Xbra in dorsal mesoderm
29. Transcriptional regulation of Xvent homeobox genes