Increased secretion of the pancreatic secretory trypsin inhibitor (PSTI-I, monitor peptide) during development of chronic pancreatitis in the WBN/Kob rat

Pancreatology

Volumn 2, Issue 2, 2002, Pages 108-115

  Graf, R ^a   Schiesser, M ^a   Bimmler, D ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Acute pancreatitis; Coordinate regulation; Immunohistochemistry; Pancreas; Pancreatic stone protein; Secretory stress proteins

Indexed keywords

APROTININ; ISOPROTEIN; TRYPSIN; TRYPSINOGEN;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC PANCREATITIS; CONTROLLED STUDY; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; MALE; MASS SPECTROMETRY; MUTATION; NONHUMAN; PANCREAS JUICE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN SECRETION; RAT;

EID: 0036279126     PISSN: 14243903     EISSN: 14243911     Source Type: Journal    
DOI: 10.1159/000055900     Document Type: Article

References (30)

1. Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene
2. Hereditary pancreatitis: New insights into acute and chronic pancreatitis
3. Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis
4. On the cDNAs for two types of rat pancreatic secretory trypsin inhibitor
5. WBN/Kob rats. A new spontaneously occurring model of chronic pancreatitis
6. Diabetic strain (WBN/Kob) of rat characterized by endocrine-exocrine pancreatic impairment due to distinct fibrosis
7. Alcoholic pancreatitis
8. Pancreatic secretory enzymes
9. In a rat model of chronic pancreatitis (WBN/Kob), levels of PSP/reg in pancreatic juice are highly increased in the early phase of the disease
10. Characterization of a protein isolated from pancreatic calculi of men suffering from chronic calcifying pancreatitis
11. Trypsin inhibitor from human pancreas and pancreatic juice
12. Pancreatic secretory trypsin inhibitor, cathodal trypsin, and pancreatic elastase in pancreatic juice collected at endoscopic retrograde cholangiopancreatography
13. Abnormalities in pancreatic secretory profiles of patients with cancer of the pancreas
14. Radioimmunoassay for human pancreatic secretory trypsin inhibitor: Measurement of serum pancreatic secretory trypsin inhibitor in normal subjects and subjects with pancreatic diseases
15. Regulation of PSP/reg in rat pancreas: Immediate and steady-state adaptation to different diets
16. Effect of a high-protein diet on the gene expression of a trypsin-sensitive, cholecystokinin-releasing peptide (monitor peptide) in the pancreas
17. Purification and sequencing of a trypsin-sensitive cholecystokinin-releasing peptide from rat pancreatic juice. Its homology with pancreatic secretory trypsin inhibitor
18. Optimization of the solubilization and renaturation of fish growth hormone produced by Escherichia coli
19. 2
20. Selective assay method with use of heat stability for a trypsin-sensitive cholecystokinin-releasing peptide (monitor peptide) in rat bilepancreatic juice
21. Spontaneous diabetes-like syndrome in WBN/Kob rats
22. Pancreatitis. The role of lysosomes
23. Possible lysosomal activation of pancreatic zymogens. Activation of both human trypsinogens by cathepsin B and spontaneous acid activation of human trypsinogen 1
24. The measurement of serum immunoreactive pancreatic secretory trypsin inhibitor in gastrointestinal cancer and pancreatic disease
25. Pancreatic secretory trypsin inhibitor as an acute phase reactant
26. Physiological characteristics of spontaneously developed diabetes in male WBN/Kob rat and prevention of development of diabetes by chronic oral administration of synthetic trypsin inhibitor (FOY-305)
27. Effect of oral administration of protease inhibitor on pancreatic exocrine function in WBN/Kob rats with chronic pancreatitis
28. The protective effects of long-acting recombinant human pancreatic secretory trypsin inhibitor (R44S-PSTI) in a rat model of cerulein-induced pancreatitis
29. Adaptive response of the rat pancreas to dietary substrates: Parallel regulation of trypsinogen and pancreatic secretory trypsin inhibitor
30. Chronic ethanol consumption induces gene expression of pancreatic monitor peptide, but not SPINK1/PSTI-56, in rats