Dexniguldipine hydrochloride, a protein-kinase-C-specific inhibitor, affects the cell cycle, differentiation, P-glycoprotein levels, and nuclear protein phoshorylation in Friend erythroleukemia cells

Journal of Cancer Research and Clinical Oncology

Volumn 122, Issue 8, 1996, Pages 465-475

  Patterson, K K ^a   Beckman, B S ^a   Klotz, D M ^a   Mallia, C M ^a   Jeter Jr , J R ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cell differentiation; cell proliferation; Dexniguldipine hydrochloride; nuclear protein phosphorylation; protein kinase C

Indexed keywords

ANTINEOPLASTIC AGENT; DEXNIGULDIPINE; GLYCOPROTEIN P; PROTEIN KINASE C INHIBITOR;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; ERYTHROLEUKEMIA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ACETAMIDES; ANIMALS; ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL DIFFERENTIATION; DIHYDROPYRIDINES; FRIEND MURINE LEUKEMIA VIRUS; LEUKEMIA, ERYTHROBLASTIC, ACUTE; MICE; MICE, INBRED DBA; NUCLEAR PROTEINS; P-GLYCOPROTEIN; PHOSPHORYLATION; PROTEIN KINASE C; TUMOR CELLS, CULTURED;

EID: 0030010912     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01187158     Document Type: Article

References (60)

1. Aftab DT, Yang JM, Hait WN (1994) Functional role of phosphorylation of the multidrug transporter (P-glycoprotein) by protein kinase C in multidrug-resistant MCF-7 cells (abstract). Oncol Res 6: 5970
2. Aihara H, Asaoka Y, Yoshida K, Nishizuka Y (1991) Sustained activation of protein kinase C is essential to HL-60 cell differentiation to macrophage. Proc Nail Acad Sci USA 88: 11 062-11 066
3. Akinaga S, Nomura K, Gomi K, Okabe M (1994) Effect of UCN-01, a selective inhibitor of protein kinase C, on the cell-cycle distribution of human epidermoid carcinoma. A431 cells. Cancer Chemother Pharmacol 33: 273-280
4. Beckman BS (1992) Nuclear protein kinase C activity is decreased in Friend erythroleukemia cells induced to differentiate. Exp Hematol 20: 324-327
5. Beckman BS, Kopfler W, Koury P, Jeter JR Jr (1987) Effect of Aphidicolin on Friend erythroleukemic cell maturation. Exp Cell Res 169: 223-232
6. Beckman BS, Mason-Garcia M, Martinez MI, Fermin C (1990) Enhanced expression of the βII subspecies of protein kinase C in differentiating erythroleukemia cells. Exp Cell Res 191: 319-322
7. Billi AM, Matteucci A, Bertagnolo V, Previati M, Manzoli FA, Capitani S (1991) In vitro phosphorylation of lamin B by protein kinase C in friend erythroleukemia. Effect of chemically induced differentiation. Cell Biol Int Rep 15: 409-426
8. Blobe GC, Khan WA, Halpern AE, Obeid LM, Hannun YA (1993) Selective regulation of expression of protein kinase C β isoenzymes occurs via alternative splicing. J Biol Chem 268: 10627-10635
9. Buckley AR, Crowe PD, Russell DH (1988) Rapid activation of protein kinase C in isolated rat liver nuclei by prolactin, a known hepatic mitogen. Proc Natl Acad Sci USA 85: 8649-8653
10. Capitani S, Mazzoni M, Bertagnolo V, et al (1990) Nuclear inositol lipids in Friend erythroleukemia cells. Changes related to differentiation induced by hexamethylenebisacetamide. Cell Biol Int Rep 14: 783-796
11. Chambers TC, McAvoy EM, Jacobs JW, Elion G (1990) Protein kinase C phosphorylates P-glycoprotein in multidrug resistant human KB carcinoma cells. J Biol Chem 265: 7679-7686
12. Crissman HA, Gadbois DM, Tobey RA, Bradbury EM (1991) Transformed mammalian cells are deficient in kinase-mediated control of progression through the Gl phase of the cell cycle. Proc Natl Acad Sci USA 88: 7580-7584
13. Dinnen R, Ebisuzaki K (1990) Mitosis may be an obligatory route to terminal differentiation in the Friend erythroleukemia cell. Exp Cell Res 191: 149-152
14. Eckberg WR, Palazzo RE (1992) Regulation of M-phase progression in Chaetopterus oocytes by protein kinase C. Dev Biol 149: 395-405
15. Efferth T, Volm M (1992) Expression of protein kinase C in human renal cell carcinoma cells with inherent resistance to doxorubicin. Anticancer Res 12: 2209-2211
16. Epstein J, Xiao H, Oba B (1989) P-glycoprotein expression in plasma cell myeloma is associated with resistance to VAD. Blood 74: 913-917
17. Fine R, Patel J, Chabner B (1988) Selective regulation of expression of PKC isoenzymes in multidrug resistance MCF-7 cells. Proc Natl Acad Sci USA 85: 582-586
18. Flint AJ, Paladini RD, Koshland DE Jr (1990) Autophosphorylation of protein kinase C at three separated regions of its primary sequence. Science 249: 408-411
19. Gietzen K, Bai G, Abdallah F (1990) Selective inhibition of proliferation by a novel dihydropyridine derivative with anticalmodulin activity in the mammary tumor cell line ZR75-1. Med Sci Res 18: 627-629
20. Greengard P (1978) Phosphorylated proteins as physiological effectors. Science 199: 146-152
21. Grogan T, Dalton W, Rybski J, et al (1990) Optimization of immunocytochemical P-glycoprotein. Assessment in multidrug-resistant plasma cell myeloma using three antibodies. Lab Invest 63: 815-824
22. Gros P, Neriah Y, Croop JM, Housman DE (1986) Isolation and expression of a complementary DNA that confers multidrug resistance. Nature 323: 728-734
23. Grove JR, Price DJ, Goodman HM, Avruch J (1987) Recombinant of protein kinase inhibitor blocks cyclic AMP-dependent gene transcription. Science 238: 530-536
24. Hocevar B, Fields A (1991a) Selective translocation of βII protein kinase C to the nucleus of human promyelocytic (HL-60) leukemia cells. J Biol Chem 266: 28-33
25. Hocevar BA, Morrow DM, Tykocinski ML, Fields AP (1992) Protein kinase C in isotypes in human erythroleukemia cell proliferation and differentiation. J Cell Sci 101: 671-679
26. Hofmann J, Uberall F, Egle A, Grunicke H (1991) B859-35, a new drug with anti-tumor activity reverses multidrug resistance. Int J Cancer 47: 870-874
27. Hofmann J, Wolf A, Spitaler M, et al (1992) Reversal of multidrug resistance by B859-35, a metabolite of B859-35, niguldipine, verapamil and nitrendipine. J Cancer Res Clin Oncol 118: 361-366
28. +2-activated and phospholipiddependent protein kinase. J Biol Chem 261: 12 134-12 140
29. Jeter JR Jr, Knieriem KM, Cameron IL (1976) Synthesis of nuclear acidic proteins in mature and immature avian erythrocytes. Cytobios 15: 183-189
30. Jungmann RA, Laks MS, Harrison JJ, Suter P, Jones CE (1981) Modulation of nuclear protein kinases at times of genetic activity. In: Rosen OM, Krebs EG (eds) Protein phosphorylation, vol I. Cold Spring Harbor Press, Cold Spring Harbor, NY, pp 1109-1126
31. Kartner N. Riordan JR, and Ling V (1983) Cell surface p-glycoprotein associated with multidrug resistance in mammalian cells. Science 221: 1285-1288
32. 1. Proc Natl Acad Sci USA 90: 6746-6750
33. Krishan A (1975) Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. J Cell Biol 66: 188-193
34. Krishan A, Sauerteig A, Stein J (1991) Comparison of three commercially available antibodies for flow cytometric monitoring of p-glycoprotein expression in tumor cells. Cytometry 12: 731-742
35. 4. Nature 227: 680-685
36. Lee S, Karaszkiewicz. J, Anderson W (1992) Elevated level of nuclear PKC in multidrug resistant MCF-7 human breast carcinoma cells. Cancer Res 52: 3750-3759
37. Mallia CM, Jeter JR Jr, Fields AP, Wilson RB, Beckman BS (1993) Protein kinase C β from Friend erythroleukemia cells is associated with chromatin and DNA. Mol Cell Biochem 34: 89
38. Mason-Garcia M, Weill CL, Beckman BS (1990) Rapid activation by erythropoietin of protein kinase C in nuclei of erythroid progenetor cells. Biochem Biophys Res Commun 168: 490-497
39. Melloni E, Pontremoli S, Michetti M, et al (1987) Protein kinase C activity and hexamethylenebisacetamide-induced erythroleukemia cell differentiation. Proc Natl Acad Sci USA 84: 5282-5286
40. Melloni E, Pontremoli S, Sparatore B, et al (1990) Introduction of the β isozyme of protein kinase C accelerates induced differentiation of murine erythroleukemia cells. Proc Natl Acad Sci USA 87: 4417-4420
41. Mitchell FE, Marais RM, Parker PJ (1989) The phosphorylation of protein kinase C as a potential measure of activation. Biochem J 261: 131-136
42. Mitchell SJ, Kleinsmith LJ (1983) Nuclear protein kinases. In: Hnilica LS (ed) Chromosomal nonhistone proteins, vol 3. CRC, Boca Raton, Fla, pp 131-171
43. Neumann JR, Housman D, Ingram VM (1978) Nuclear protein synthesis and phosphorylation in Friend erythroleukemia cells stimulated with DMSO. Exp Cell Res 111: 277-284
44. Ogawa M, Parmley RT, Bank HL, Spicer SS (1976) Human marrow erythropoiesis in culture. I. Characterization of methylcellulose colony assay. Blood 48: 407-417
45. Posada J, Vichi P, Tritton TR (1989) Protein kinase C in Adriamycin action and resistance in mouse sarcoma 180 cells. Cancer Res 49: 6634-6639
46. Reymann A, Looft G, Woermann C, Dietel M, Erttmann R (1993) Reversal of multidrug resistance in Friend leukemia cells by dexniguldipine-HCl. Cancer Chemother Pharmacol 32: 25-30
47. Riordan JR and Ling V (1985) Genetic and biochemical characterization of multidrug resistance. Pharmacol Ther 28: 51-75
48. Roesler WJ, Vandenbark GR, Hanson RW (1988) Cyclic AMP and the induction of eukaryotic gene transcription. J Biol Chem 263: 9063-9066
49. Roninson IB, Chin JE, Choid K, et al (1986) Isolation of human multidrug resistance DNA sequences amplified in multidrug resistant KB carcinoma cells. Proc Natl Acad Sci USA 83: 4538-4542
50. 1/S inhibition. Exp Cell Res 208: 311-320
51. +2-channel blocker verapamil on human lung cancer cell lines. Carcinogenesis 12: 2301-2303
52. Schuller HM, Orloff M, Reznik GK (1994) Inhibition of protein-kinase-C-dependent cell proliferation of human lung cancer cell lines by the dehydropyridine dexniguldipine. J Cancer Res Clin Oncol 120: 354-358
53. 2-terminal domain of c-myc increases transactivation of gene expression. J Biol Chem 266: 23 521-23 524
54. Silliman CC, Beckman BS, Jeter JR Jr (1993) Changes in protein kinase activity within thirty minutes of induced differentiation in Friend erythroleukemia cells. Biochem Cell Biol 1: 1-6
55. Spriggs LL, Hill SM, Jeter JR Jr (1992) Proliferation is required for induction of terminal differentiation of Friend erythroleukemia cells. Biochem Cell Biol 70: 555-564
56. Spruill WA, Hurwitz DR, Lucchesi JC, Steiner AL (1978) Association of cyclic GMP with gene expression of polytene chromosomes of Drosophilia melanogasater. Proc Natl Acad Sci USA 75: 1480-1484
57. Towbin H, Staehelin T, Gordon J (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76: 4350-4354
58. Uberall F, Maly K, Egle A, Doppler W, Hofmann J, Grunicke HH (1991) Inhibition of cell proliferation, protein kinase C, and phorbol ester-induced expression by the dihydropyridine derivative B859-35. Cancer Res 51: 5821-5825
59. Yu G, Ahmad S, Aquino A, et al (1991) Transfection with PKC-α confers increased multidrug resistance to MCF-7 cells expressing p-glycoprotein. Cancer Commun 3: 181-189
60. Zhou W, Takuwa N, Kumada M, Takuwa Y (1993) Protein kinase C-mediated bidirectional regulation of DNA synthesis, RB protein phosphorylation, and cyclin-dependent kinases in human vascular endothelial cells. J Biol Chem 268: 23041-23048