Attention deficit hyperactivity disorder and the gene for dopamine beta-hydroxylase

American Journal of Psychiatry

Volumn 159, Issue 6, 2002, Pages 1046-1048

  Wigg, Karen ^a   Zai, Gwyneth ^a   Schachar, Russell ^a   Tannock, Rosemary ^a   Roberts, Wendy ^a   Malone, Molly ^a   Kennedy, James L ^a   Barr, Cathy L ^a  

^a TORONTO WESTERN HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE BETA MONOOXYGENASE;

ARTICLE; ATTENTION DEFICIT DISORDER; CHILD; DNA POLYMORPHISM; DOPAMINERGIC SYSTEM; HAPLOTYPE; HERITABILITY; HUMAN; MAJOR CLINICAL STUDY; MOLECULAR GENETICS; NORADRENERGIC SYSTEM; PRIORITY JOURNAL;

ALLELES; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CHROMOSOME MAPPING; DOPAMINE BETA-HYDROXYLASE; GENE FREQUENCY; HAPLOTYPES; HUMANS; INTRONS; LINKAGE (GENETICS); NUCLEAR FAMILY; POLYMORPHISM, GENETIC;

EID: 0036268047     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/appi.ajp.159.6.1046     Document Type: Article

References (8)

1. Mapping susceptibility loci in attention deficit hyperactivity disorder: Preferential transmission of parental alleles at DAT1, DBH and DRD5 to affected children
2. A haplotype at the DBH locus, associated with low plasma dopamine beta-hydroxylase activity, also associates with cocaine-induced paranoia
3. Possible control of dopamine beta-hydroxylase via a codominant mechanism associated with the polymorphic (GT)n repeat at its gene locus in healthy individuals
4. Further evidence from haplotype analysis for linkage of the dopamine D4 receptor gene and attentiondeficit hyperactivity disorder
5. A 19 bp deletion polymorphism adjacent to a dinucleotide repeat polymorphism at the human dopamine beta-hydroxylase locus
6. An extended transmission/disequilibrium test (TDT) for multi-allele marker loci
7. A generalization of the transmission/disequilibrium test for uncertain-haplotype transmission