Differing effects of methylenetetrahydrofolate reductase single nucleotide polymorphisms on methotrexate efficacy and toxicity in rheumatoid arthritis

Pharmacogenetics

Volumn 12, Issue 3, 2002, Pages 181-182

  Evans, William E ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); C REACTIVE PROTEIN; DNA; FOLIC ACID; FOLINIC ACID; HOMOCYSTEINE; METHOTREXATE;

ALLELE; DRUG EFFICACY; GASTROINTESTINAL TOXICITY; GENE; GENE LINKAGE DISEQUILIBRIUM; HAPLOTYPE; HUMAN; LIVER TOXICITY; MUCOSA INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SHORT SURVEY; SINGLE NUCLEOTIDE POLYMORPHISM;

ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; GENOTYPE; HAPLOTYPES; HUMANS; JAPAN; METHOTREXATE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; POLYMORPHISM, SINGLE NUCLEOTIDE; TREATMENT OUTCOME;

EID: 0036267170     PISSN: 0960314X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008571-200204000-00001     Document Type: Short Survey

References (19)

1. Polymorphisms in the methylenetetrahydrofolate reductase gene were associated with both the efficacy and the toxicity of methotrexate used for the treatment of rheumatoid arthritis, as evidenced by single locus and haplotype analyses
2. Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida
3. C677T homozygosity associated with thermolabile 5,10-methylenetetrahydrofolate reductase as a risk factor for neural tube defects
4. Molecular genetic analysis in mild hyperhomocysteinemia: A common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease
5. Pharmacogenetics of methotrexate: Toxicity among marrow transplantation patients varies with the methylenetetrahydrofolate reductase C677T polymorphism
6. The C677T mutation in the methylenetetrahydrofolate reductase gene: A genetic risk factor for methotrexate-related elevation of liver enzymes in rheumatoid arthritis patients
7. Molecular genetics of methylenetetrahydrofolate reductase deficiency
8. Effect of folic or folinic acid supplementation on the toxicity and efficacy of methotrexate in rheumatoid arthritis; a 48 week, multicenter, randomized, double-blind, placebo-controlled study
9. Association of methylenetetrahydrofolate reductase polymorphism C677T and dietary folate with the risk of cervical dysplasia
10. Determination of probability distribution of diplotype configuration (diplotype distribution) for each subject using haplotype frequencies estimated by EM algorithm: Comparison of the estimated diplotype configuration with that determined by in vitro experiments
11. A second common mutation in the methylenetetrahydrofolate reductase gene: An additional risk factor for neural-tube defects?
12. A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity
13. Molecular haplotyping of genomic DNA for multiple single nucleotide polymorphisms located kilobases apart, using long-range PCR and intramolecular ligation
14. Antiepileptic drug treatment in children: Hyperhomocysteinaemia, B-vitamins and the 677C > T mutation of the methylenetetrahydrofolate reductase gene
15. A common mutation in the methylenetetrahydrofolate reductase gene is a determinant of hyperhomocysteinemia in epileptic patients receiving anticonvulsants
16. Plasma homocysteine and MTHFR C677T genotype in levodopa-treated patients with PD
17. The C677T methylenetetrahydrofolate reductase polymorphism influences the homocysteine-lowering effect of hormone replacement therapy
18. The C677T mutation in the methylenetetrahydrofolate reductase gene predisposes to hyperhomocysteinemia in children with familial hypercholesterolemia treated with cholestyramine
19. Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition