Effects of age and gene dose on skeletal muscle sodium channel gating in mice deficient in myotonic dystrophy protein kinase

Muscle and Nerve

Volumn 25, Issue 6, 2002, Pages 850-857

  Reddy, Sita ^a   Mistry, Dilaawar J ^b   Wang, Qing Cai ^a   Geddis, Lisa M ^c   Kutchai, Howard C ^c   Moorman, J Randall ^b,c   Mounsey, J Paul ^b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Aging; Myotonic dystrophy; Myotonic dystrophy protein kinase; Patch clamp; Saxitoxin; Sodium channels

Indexed keywords

PROTEIN KINASE; SODIUM CHANNEL;

ADOLESCENT; AGE; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; ELECTROPHYSIOLOGY; GENE DOSAGE; MEMBRANE DEPOLARIZATION; MOUSE; MYOTONIC DYSTROPHY; NONHUMAN; PRIORITY JOURNAL; SKELETAL MUSCLE; SODIUM CURRENT;

AGING; ANIMALS; CELL SEPARATION; DISEASE MODELS, ANIMAL; GENE DOSAGE; ION CHANNEL GATING; KINETICS; MEMBRANE POTENTIALS; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; MUSCLE, SKELETAL; MYOTONIC DYSTROPHY; PATCH-CLAMP TECHNIQUES; PROTEIN-SERINE-THREONINE KINASES; RADIOLIGAND ASSAY; SAXITOXIN; SODIUM CHANNELS;

EID: 0036266580     PISSN: 0148639X     EISSN: None     Source Type: Journal    
DOI: 10.1002/mus.10127     Document Type: Article

References (35)

1. A reinterpretation of mammalian sodium channel gating based on single channel recording
2. Voltage-dependent gating of single sodium channels from mammalian neuroblastoma cells
3. + channel by protein kinase C
4. DMPK dosage alterations result in atrioventricular conduction abnormalities in a mouse myotonic dystrophy model
5. Myotonic dystrophy kinase modulates skeletal muscle but not cardiac voltage-gated sodium channels
6. Sodium channel and sodium pump in normal and pathological muscles from patients with myotonic muscular dystrophy and lower motor neuron impairment
7. Simultaneous analysis of expression of the three myotonic dystrophy locus genes in adult skeletal muscle samples: The CTG expansion correlates inversely with DMPK and 59 expression levels, but not DMAHP levels
8. - conductance in resealed muscle fibre segments from patients with myotonic dystrophy
9. Modulation of cardiac sodium channel isoform by cyclic AMP dependent protein kinase does not depend on phosphorylation of serine 1504 in the cytosolic loop interconnecting transmembrane domains III and IV
10. Decreased expression of myotonin-protein kinase messenger RNA and protein in adult form of myotonic dystrophy
11. Myotonic dystrophy: Will the real gene please step forward
12. Abnormal myotonic dystrophy protein kinase levels produce only mild myopathy in mice
13. The expression of ion channel mRNAs in skeletal muscles from patients with myotonic muscular dystrophy
14. Contractile properties of single muscle fibers in myotonic dystrophy
15. Functional modulation of brain sodium channels by cAMP-dependent phosphorylation
16. Convergent regulation of sodium channels by protein kinase C and cAMP-dependent protein kinase
17. Identification, tissue-specific expression, and subcellular localization of the 80- and 71-kDa forms of myotonic dystrophy kinase protein
18. Contributions of charged residues in a cytoplasmic linking region to Na channel gating
19. Cardiac involvement in myotonic muscular dystrophy
20. Skeletal muscle sodium channel gating in mice deficient in myotonic dystrophy protein kinase
21. Modulation of skeletal muscle sodium channels by human myotonin protein kinase
22. Procedures for comparing samples with multiple endpoints
23. Genetics and physiology of the myotonic muscle disorders
24. Mice lacking the myotonic dystrophy protein kinase develop a late onset progressive myopathy
25. Myotonic dystrophy
26. Myotonic dystrophy
27. Isoform diversity and modulation of sodium channels by protein kinases
28. Phosphorylation of brain sodium channels in the I-II linker modulates channel function in Xenopus oocytes
29. Decreased expression of myotonic dystrophy protein kinase and disorganization of sarcoplasmic reticulum in skeletal muscle of myotonic dystrophy
30. A new algorithm for idealizing single ion channel data containing multiple unknown conductance levels
31. Myotonic dystrophy
32. A phosphorylation site in the Na+ channel required for modulation by protein kinase C
33. Phosphorylation of the rat skeletal muscle sodium channel by cyclic AMP-dependent protein kinase