Inhibition of mitochondrial function affects cellular Ca2+ handling in pancreatic B-cells

Pflugers Archiv European Journal of Physiology

Volumn 444, Issue 1-2, 2002, Pages 236-243

  Düfer, Martina ^a   Krippeit Drews, Peter ^a   Drews, Gisela ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

B cell ion channels; Ca2+ homeostasis; Cytosolic free Ca2+ concentration ( Ca2+ c; Mitochondria; Sodium azide

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM CHANNEL L TYPE; CALCIUM ION; CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; GLUCOSE; INSULIN; POTASSIUM CHANNEL; SODIUM AZIDE; THAPSIGARGIN;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM MOBILIZATION; CALCIUM SIGNALING; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; EXTRACELLULAR CALCIUM; FEMALE; HYPERPOLARIZATION; INSULIN RELEASE; MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PATCH CLAMP; PRIORITY JOURNAL;

ANIMALS; AZIDES; CALCIUM; CALCIUM CHANNELS, L-TYPE; CARBONYL CYANIDE P-TRIFLUOROMETHOXYPHENYLHYDRAZONE; ELECTROPHYSIOLOGY; ENZYME INHIBITORS; FEMALE; ION CHANNEL GATING; ISLETS OF LANGERHANS; MEMBRANE POTENTIALS; MICE; MITOCHONDRIA; PATCH-CLAMP TECHNIQUES; THAPSIGARGIN; UNCOUPLING AGENTS;

EID: 0036264405     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00424-002-0799-8     Document Type: Article

References (39)

1. Electrophysiology of the pancreatic β-cell
2. 2+ loads in lizard motor nerve terminals
3. 2+ and the ATP/ADP ratio: A feedback control mechanism in mouse pancreatic islets
4. Two sites of glucose control of insulin release with distinct dependence on the energy state in pancreatic B-cells
5. Contributions of mitochondria to animal physiology: From homeostatic sensor to calcium signalling and cell death
6. 2+ in pancreatic β-cells exhibits graded dependence on the filling of the endoplasmic reticulum
7. 2+ in single pancreatic β-cells
8. 2+ indicators with greatly improved fluorescence properties
9. ATP channel currents in the rat CRI-G1 insulinoma cell line
10. Mitochondrial control of calcium-channel gating: A mechanism for sustained signaling and transcriptional activation in T lymphocytes
11. Depletion of intracellular calcium stores activates a calcium current in mast cells
12. Calcium release-activated calcium current in rat mast cells
13. Role of mitochondrial calcium in metabolism-secretion coupling in nutrient-stimulated insulin release
14. Parallel oscillations of intracellular calcium activity and mitochondrial membrane potential in mouse pancreatic B-cells
15. 2 with stimulus-secretion coupling in mouse pancreatic β-cells
16. Identification of an ATP-sensitive potassium channel current in rat striatal cholinergic interneurones
17. 2+ channels in pancreatic β-cells
18. 2+ in pancreatic β-cells without participation of the thapsigargin-sensitive store
19. 2+ entry in insulin-releasing pancreatic β-cells
20. Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic β-cells
21. The role of mitochondria in the regulation of calcium influx into Jurkat cells
22. Effects of metabolic inhibition by sodium azide on stimulus-secretion coupling in B cells of human islets of Langerhans
23. 2+ entry
24. 2+ entry in mouse pancreatic β-cells by both direct and indirect mechanisms
25. 2+ transients that modulate secretion
26. Mitochondria buffer nontoxic calcium loads and release calcium through the mitochondrial permeability transition pore and sodium/calcium exchanger in rat basal forebrain neurons
27. 2+ transport in islet cell plasma membrane
28. Properties and calcium-dependent inactivation of calcium currents in cultured mouse pancreatic B-cells
29. 2+ concentration by rat insulinoma mitochondria
30. 2+ contributes to oscillations of the membrane potential in pancreatic β-cells
31. Energetic requirement of insulin secretion distal to calcium influx
32. Calcium signal transmission between ryanodine receptors and mitochondria
33. 2+ stores in individual pancreatic β-cells
34. ATP channel
35. NCX1 Na/Ca exchanger splice variants in pancreatic islet cells
36. 2+ stores activates a maitotoxin-sensitive nonselective cationic current in β-cells
37. Sarcoplasmic reticulum vesicles embedded in agarose gel exhibit propagating calcium waves
38. The mitochondrial permeability transition
39. 2+ stores