Chromaffin cell catecholamine secretion: Bisindolylmaleimide compounds exhibit novel and potent antagonist effects at the nicotinic cholinergic receptor in pheochromocytoma cells

Molecular Pharmacology

Volumn 61, Issue 6, 2002, Pages 1340-1347

  Mahata, Manjula ^a,b   Mahapatra, Nitish R ^a,b   O'Connor, Daniel T ^a,b   Mahata, Sushil K ^a,b  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA BUNGAROTOXIN; ANATOXIN; BISINDOLYLMALEIMIDE; CATECHOLAMINE; CYSTINE; DIHYDRO BETA ERYTHROIDINE; DIMETHYL SULFOXIDE; EPIBATIDINE; HEXAMETHONIUM; MECAMYLAMINE; NICOTINE; NICOTINIC AGENT; NICOTINIC RECEPTOR; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; SUBSTANCE P; TUBOCURARINE CHLORIDE;

ANIMAL CELL; ARTICLE; CATECHOLAMINE RELEASE; CELL STRAIN; CHROMAFFIN CELL; CONTROLLED STUDY; ENZYME INHIBITION; IC 50; NONHUMAN; PHEOCHROMOCYTOMA; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING, COMPETITIVE; CATECHOLAMINES; CHROMAFFIN CELLS; ENZYME ACTIVATION; ENZYME INHIBITORS; INDOLES; MALEIMIDES; NICOTINE; NICOTINIC ANTAGONISTS; PC12 CELLS; PHEOCHROMOCYTOMA; PROTEIN KINASE C; RATS; RECEPTORS, NICOTINIC;

EID: 0036262409     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.61.6.1340     Document Type: Article

References (26)

1. The "calcium antagonist" TMB-8 [3,4,5-trimethoxybenzoic acid 8-(diethylamino)octyl ester] is a potent, noncompetitive, functional antagonist at diverse nicotinic acetylcholine receptor subtypes
2. Protein kinase C and clostridial neurotoxins affect discrete and related steps in the secretory pathway
3. Inhibitors of protein kinase C. 2. Substituted bisindolylmaleimides with improved potency and selectivity
4. Inhibitors of protein kinase C. 1,2,3-Bisarylmaleimides
5. Competitive neuronal nicotinic receptor antagonists: A new direction for drug discovery
6. Protein kinase C enhances exocytosis from chromaffin cells by increasing the size of the readily releasable pool of secretory granules
7. Measurement of exocytosis by amperometry in adrenal chromaffin cells: Effects of clostridial neurotoxins and activation of protein kinase C on fusion pore kinetics
8. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor
9. The phorbol ester TPA increases the affinity of exocytosis for calcium in 'leaky' adrenal medullary cells
10. Vesicular monoamine transport inhibitors. Novel action at calcium channels to prevent catecholamine secretion
11. 344-364) acts at the receptor to prevent nicotinic cholinergic tolerance
12. Inhibition of nicotinic responses of bovine adrenal chromaffin cells by the protein kinase C inhibitor. Ro 31-8220
13. Effects of phorbol ester on catecholamine secretion and protein phosphorylation in adrenal medullary cell cultures
14. The expression of nicotinic acetylcholine receptors by PC12 cells treated with NGF
15. Alpha subunit composition of nicotinic acetylcholine receptors in the rat autonomic ganglia neurons as determined with subunitspecific anti-alpha(181-192) peptide antibodies
16. Effects of protein kinase C activator and inhibitor on adrenal catecholamine release in response to splanchnic nerve stimulation in anesthetized dogs
17. 2+ channels
18. 2+ influx causes rapid translocation of protein kinase C to membranes. Studies of the effects of secretagogues in adrenal chromaffin cells
19. Effects of phorbol esters, diglyceride and cholinergic agonists on the subcellular distribution of protein kinase C in intact or digitonin-permeabilized adrenal chromaffin cells
20. Activation of protein kinase C is not required for exocytosis from bovine adrenal chromaffin cells. The effects of protein kinase C(19-31), Ca/CaM kinase II(291-317) and staurosporine
21. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C
22. Mechanism of action of chromogranin A on catecholamine release: Molecular modeling of the catestatin region reveals a β-strand/loop/β-strand structure secured by hydrophobic interactions and predictive of activity
23. A model of the nicotinic receptor extracellular domain based on sequence identity and residue location
24. Chromaffin cell cortical actin network dynamics control the size of the release-ready vesicle pool and the initial rate of exocytosis
25. + but not by muscarine in rat adrenal medulla
26. Presynaptic nicotinic ACh receptors