Molecular interactions in pulmonary surfactant films

Biology of the Neonate

Volumn 81, Issue SUPPL. 1, 2002, Pages 6-15

  Pérez Gil, Jesús ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Phospholipids; Pulmonary surfactants; Surface tension; Surfactant proteins

Indexed keywords

ARTIFICIAL LUNG SURFACTANT; LUNG SURFACTANT;

ADULT RESPIRATORY DISTRESS SYNDROME; BREATHING MECHANICS; BREATHING PATTERN; CONFERENCE PAPER; EXPIRED AIR; HUMAN; LUNG ALVEOLUS; LUNG ALVEOLUS SURFACE TENSION; LUNG MODEL; MOLECULAR INTERACTION; NEONATAL RESPIRATORY DISTRESS SYNDROME; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION;

ANIMALS; BIOPHYSICS; LIPID METABOLISM; MODELS, BIOLOGICAL; PROTEINS; PULMONARY SURFACTANTS;

EID: 0036254555     PISSN: 00063126     EISSN: None     Source Type: Journal    
DOI: 10.1159/000056765     Document Type: Conference Paper

References (68)

1. Pulmonary surfactant: Functions, abnormalities and therapeutic options
2. Biology of surfactant
3. Surfactant in respiratory distress syndrome and lung injury
4. Alveolar surfactant and adult respiratory distress syndrome. Pathogenetic role and therapeutic prospects
5. Principles of surfactant replacement
6. Surfactant alteration and replacement in acute respiratory distress syndrome
7. Treatment of ARDS with a recombinant SP-C (rSP-C) based synthetic surfactant
8. Pulmonary surfactant: Functions and molecular composition
9. The role of lipids in pulmonary surfactant
10. Surfactant-associated proteins: Functions and structural variation
11. Surfactant proteins A and D and pulmonary host defense
12. Function of surfactant proteins B and C
13. Synthesis, processing and secretion of surfactant proteins B and C
14. Role of surfactant protein A (SP-A)/lipid interactions for SP-A functions in the lung
15. Characteristics of surfactant from SP-A-deficient mice
16. Altered surfactant function and structure in SP-A gene targeted mice
17. Pulmonary surfactant-associated protein A enhances the surface activity of lipid extract surfactant and reverses inhibition by blood proteins in vitro
18. Pulmonary surfactant proteins A and D are potent endogenous inhibitors of lipid peroxidation and oxidative cellular injury
19. Interfacial properties of surfactant proteins
20. Surface tensions of lung extracts
21. Direct determination of volume- and time-dependence of alveolar surface tension in excised lungs
22. Interaction of lung surfactant proteins with anionic phospho-lipids
23. Subfractionation of lung surfactant. Implications for metabolism and surface activity
24. Morphologic evidence that large inflations of the lung stimulate secretion of surfactant
25. Mechanisms of surfactant exocytosis in alveolar type II cells in vitro and in vivo
26. Reconstitution of tubular myelin from synthetic lipids and proteins associated with pig pulmonary surfactant
27. Changes in lipid structure produced by surfactant proteins SP-A, SP-B, and SP-C
28. Effects of surfactant apolipo-proteins on liposome structure: Implications for tubular myelin formation
29. Morphologic aspects of the surfactant system
30. Interfacial adsorption of simple lipid mixtures combined with hydrophobic surfactant protein from pig lung
31. Thermodynamic effects of the hydrophobic surfactant proteins on the early adsorption of pulmonary surfactant
32. Comparative adsorption of natural lung surfactant, extracted phospholipids, and artificial phospholipid mixtures to the air-water interface
33. Characterization of lipid insertion into monomolecular layers mediated by lung surfactant proteins SP-B and SP-C
34. Interaction of lipid vesicles with monomolecular layers containing lung surfactant proteins SP-B or SP-C
35. Roles of different hydrophobic constituents in the adsorption of pulmonary surfactant
36. In vitro conversion of surfactant subtypes is altered in alveolar surfactant isolated from injured lungs
37. Formation and structure of surface films: Captive bubble surfactometry
38. The surface-associated surfactant reservoir in the alveolar lining
39. Surface activity in vitro: Role of surfactant proteins
40. Different modes of interaction of pulmonary surfactant protein SP-B in phosphatidylcholine bilayers
41. Analysis of binding and membrane destabilization of phospho-lipid membranes by surfactant apoprotein B
42. Interactions of hydrophobic lung surfactant proteins SP-B and SP-C with dipalmitoylphosphatidylcholine and dipalmitoylphosphatidylglycerol bilayers studied by electron spin resonance spectroscopy
43. The role of homodimers in surfactant protein B function in vivo
44. Dimeric N-terminal segment of human surfactant protein B (dSP-B(1-25)) has enhanced surface properties compared to monomeric SP-B(1-25)
45. Distribution of the surfactant-associated protein C within a lung surfactant model film investigated by near-field optical microscopy
46. Intrinsic structural differences in the N-terminal segment of pulmonary surfactant protein SP-C from different species
47. Lipid mixing is mediated by the hydrophobic surfactant protein SP-B but not by SP-C
48. Role of lipid polymorphism in pulmonary surfactant
49. Phospholipid monolayers
50. Temperature dependence of dipalmitoyl phosphatidylcholine monolayer stability
51. The physical properties of an effective lung surfactant
52. SP-B refining of pulmonary surfactant phospholipid films
53. Pulmonary surfactant proteins SP-B and SP-C in spread monolayers at the air-water interface: II. Monolayers of pulmonary surfactant protein SP-C and phospholipids
54. Surface activity in situ, in vivo, and in the captive bubble surfactometer
55. The role of surfactant proteins in DPPC enrichment of surface films
56. Effect of pulmonary surfactant protein A and neutral lipid on accretion and organization of dipalmitoylphosphatidyl-choline in surface films
57. Lateral phase separation in interfacial films of pulmonary surfactant
58. Phase transitions in films of lung surfactant at the air-water interface
59. Phase separation in monolayers of pulmonary surfactant phospholipids at the air-water interface: Composition and structure
60. Discrepancy between phase behavior of lung surfactant phospholipids and the classical model of surfactant function
61. Combinations of fluorescently labeled pulmonary surfactant proteins SP-B and SP-C in phospholipid films
62. Phase and morphology changes in lipid monolayers induced by SP-B protein and its amino-terminal peptide
63. Formation of three-dimensional protein-lipid aggregates in monolayer films induced by surfactant protein B
64. Palmitoylation of a pulmonary surfactant protein C analogue affects the surface associated lipid reservoir and film stability
65. Altered stability of pulmonary surfactant in SP-C-deficient mice
66. Regulation of pulmonary surfactant secretion and clearance
67. Dissociation of surfactant protein B from canine surfactant large aggregates during formation of small surfactant aggregates by in vitro surface area cycling