Confirmation of the antibacterial mode of action of SB-219383, a novel tyrosyl tRNA synthetase inhibitor from a Micromonospora sp

Journal of Antibiotics

Volumn 55, Issue 4, 2002, Pages 423-426

  Greenwood, Rebecca C ^a   Gentry, Daniel R ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BACTERIAL ENZYME; ENZYME INHIBITOR; GUANOSINE 3' DIPHOSPHATE 5' DIPHOSPHATE; ISOLEUCINE; NUCLEOTIDE; TYROSINE TRANSFER RNA LIGASE; TYROSYL 2 AMINO 2 (2,4,5,8 TETRAHYDROXY 7 OXA 2 AZABICYCLO[3.2.1]OCT 3 YL)ACETIC ACID; UNCLASSIFIED DRUG; URIDINE;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENCY; ENZYME INHIBITION; IC 50; IN VITRO STUDY; MICROMONOSPORA; NONHUMAN; PRIORITY JOURNAL; PROTEIN MALNUTRITION; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS; STREPTOCOCCUS PNEUMONIAE;

MICROMONOSPORA; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE;

EID: 0036253129     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.55.423     Document Type: Article

References (9)

1. Aminoacyl tRNA synthetases as targets for new anti-infectives
2. The impact of genomics on novel antibacterial targets
3. SB-219383, a novel tyrosyl tRNA synthetase inhibitor from Micromonospora sp. I. Fermentation, isolation and properties
4. SB-219383, a novel tyrosyl tRNA synthetase inhibitor from a Micromonospora sp. II. Structure determination
5. Characterization of Streptococcus pneumoniae and Staphylococcus aureus rel genes
6. The effect of antibiotic treatment on the intracellular nucleotide pools of Staphylococcus aureus
7. The Stringent Response
8. The rel gene is essential for in vitro growth of Staphylococcus aureus
9. Occurrence of the regulatory nucleotides ppGpp and pppGpp following induction of the stringent response in staphylococci