Toxicity and dose-response studies of 1α-hydroxyvitamin D2 in a retinoblastoma xenograft model

Archives of Ophthalmology

Volumn 120, Issue 5, 2002, Pages 607-612

  Grostern, Richard J ^a   Bryar, Paul J ^b   Zimbric, Michele L ^c   Darjatmoko, Soesiawati R ^c   Lissauer, Boaz J ^c   Lindstrom, Mary J ^d   Lokken, Janice M ^c   Strugnell, Stephen A ^e   Albert, Daniel M ^c  

^a RUSH MEDICAL COLLEGE   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

^e BoneCare International Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; DOXERCALCIFEROL; ERGOCALCIFEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CALCIUM BLOOD LEVEL; CANCER GROWTH; CANCER SIZE; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DRUG BLOOD LEVEL; GROWTH INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RETINOBLASTOMA; TUMOR VOLUME; XENOGRAFT;

EID: 0036252710     PISSN: 00039950     EISSN: None     Source Type: Journal    
DOI: 10.1001/archopht.120.5.607     Document Type: Article

References (40)

1. A new era for the treatment of retinoblastoma
2. Minutes of the proceedings: 62nd annual meeting
3. Glioma retinae treated by x-rays with apparent destruction of the tumor and preservation of vision
4. Histopathologic verification of Verhoeff's 1918 irradiation cure of retinoblastoma
5. Retinoblastoma undergoing spontaneous regression: Calcifying agent suggested in treatment of retinoblastoma
6. Verhoeff's query: Is vitamin D effective in treating retinoblastoma?
7. Characteristics of an established cell line of retinoblastoma
8. Vitamin D and retinoblastoma: The presence of receptors and inhibition of growth in vitro
9. The antineoplastic effect of vitamin D in transgenic mice with retinoblastoma
10. Further studies of the effect of vitamin D on retinoblastoma inhibition with 1,25-dihydroxycholecalciferol
11. Clinical counterpoint: Vitamin D: New actions, new analogs, new treatment potential
12. 3 analogue in transgenic mice with retinoblastoma
13. 3 in rats and monkeys
14. 2 made in the human hepatoma, Hep3B
15. 3 in athymic mice with Y-79 human retinoblastoma tumors
16. Assay of circulating 1,25-dihydroxyvitamin D involving a novel single-cartridge extraction and purification procedure
17. Alternative treatment in retinoblastoma
18. Mortality from second tumors among the long-term survivors of retinoblastoma
19. Incidence of second neoplasms in patients with bilateral retinoblastoma
20. Second nonocular tumors in survivors of bilateral retinoblastoma: A possible age effect on radiation-related risk
21. Chemotherapy with focal therapy can cure intraocular retinoblastoma without radiotherapy
22. 2 in normal and immortalized human epidermal cells
23. 2 is effective and safe for the suppression of secondary hyperparathyroidism in haemodialysis patients
24. 3 in transgenic mice
25. Newly identified actions of the vitamin D endocrine system
26. The antiproliferative effect of vitamin D analogs on MCF-7 human breast cancer cells
27. Human prostate cancer cells: Inhibition of proliferation by vitamin D analogs
28. 3 analogs: Effect on leukemic clonal growth, differentiation, and serum calcium
29. 3 on a human promyelocytic leukemia cell, HL-60, at both the receptor and the postreceptor steps
30. 3 on the proliferation of pancreatic cancer cell lines
31. 3 is independent of nuclear receptor binding
32. Selective vitamin D analogs and their therapeutic applications
33. Protein kinase C (PKC) isozyme-mediated cell cycle arrest involves induction of p21waf1/cip1 and p27 kip1 and hypophosphorylation of the retinoblastoma protein in intestinal epithelial cells
34. Protein kinase C isoforms in the chemopreventive effects of a novel vitamin D3 analogue in rat colonic tumorigenesis
35. Cyclin-dependent kinase inhibitors in restriction point control, genomic stability, and tumorigenesis
36. Radiation-induced cell cycle arrest compromised by p21 deficiency
37. Combination of a potent 20-epivitamin D3 analogue (KH 1060) with 9-cis-retinoic acid irreversibly inhibits clonal growth, decreases bcl-2 expression, and induces apoptosis in HL-60 leukemic cells
38. Vitamin-D3 derivatives and breast-tumor cell growth: Effect on intracellular calcium and apoptosis
39. 1,25-Dihydroxyvitamin D3 stimulates apoptosis in CaCo-2 cells
40. p53 regulates apoptosis in human retinoblastoma